IL-12 p70 Monoclonal Antibody (20C2) | Invitrogen M122 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IL-12 p70 Monoclonal Antibody (20C2)

catalog :

M122

quantity :

500 µg

price :

US 460

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

20C2

reactivity :

human

application :

western blot, ELISA, blocking or activating experiments

more info or order :

Invitrogen product webpage

citations: 22

Published Application/Species/Sample/Dilution	Reference
blocking or activating experiments; human	Schmitt N, Bustamante J, Bourdery L, Bentebibel S, Boisson Dupuis S, Hamlin F, et al. IL-12 receptor ?1 deficiency alters in vivo T follicular helper cell response in humans. Blood. 2013;121:3375-85 pubmed publisher
ELISA; human	Dolcini G, Solana M, Andreani G, Celentano A, Parodi L, Donato A, et al. Trypanosoma cruzi (Chagas' disease agent) reduces HIV-1 replication in human placenta. Retrovirology. 2008;5:53 pubmed publisher
blocking or activating experiments; human; 1 ug/ml	Curti A, Pandolfi S, Aluigi M, Isidori A, Alessandrini I, Chiodoni C, et al. Interleukin-12 production by leukemia-derived dendritic cells counteracts the inhibitory effect of leukemic microenvironment on T cells. Exp Hematol. 2005;33:1521-30 pubmed
ELISA; human; tbl 1	Meloni F, Cascina A, Paschetto E, Marone Bianco A, Morosini M, Pellegrini C, et al. Monocyte chemoattractant protein-1 levels in bronchoalveolar lavage fluid of lung-transplanted patients treated with tacrolimus as rescue treatment for refractory acute rejection. Transplant Proc. 2003;35:1523-6 pubmed
	Kristoff J, Palma M, Garcia Bates T, Shen C, Sluis Cremer N, Gupta P, et al. Type 1-programmed dendritic cells drive antigen-specific latency reversal and immune elimination of persistent HIV-1. EBioMedicine. 2019;43:295-306 pubmed publisher
	Baranov M, Bianchi F, Schirmacher A, van Aart M, Maassen S, Muntjewerff E, et al. The Phosphoinositide Kinase PIKfyve Promotes Cathepsin-S-Mediated Major Histocompatibility Complex Class II Antigen Presentation. iScience. 2019;11:160-177 pubmed publisher
	van Beek J, Gorris M, Sköld A, Hatipoglu I, Van Acker H, Smits E, et al. Human blood myeloid and plasmacytoid dendritic cells cross activate each other and synergize in inducing NK cell cytotoxicity. Oncoimmunology. 2016;5:e1227902 pubmed
	Sittig S, Bakdash G, Weiden J, Sköld A, Tel J, Figdor C, et al. A Comparative Study of the T Cell Stimulatory and Polarizing Capacity of Human Primary Blood Dendritic Cell Subsets. Mediators Inflamm. 2016;2016:3605643 pubmed publisher
	Marchani E, Watkins W, Bulayeva K, Harpending H, Jorde L. Culture creates genetic structure in the Caucasus: autosomal, mitochondrial, and Y-chromosomal variation in Daghestan. BMC Genet. 2008;9:47 pubmed publisher
	Kowala Piaskowska A, Mozer Lisewska I, Figlerowicz M, Machowska L, Słuzewski W. Interleukin 6 and 12, alanine aminotransferase activity, and HCV viral load in children with chronic hepatitis C treated with interferon and ribavirin. Inflammation. 2004;28:319-25 pubmed
	Radstake T, van Lent P, Pesman G, Blom A, Sweep F, Ronnelid J, et al. High production of proinflammatory and Th1 cytokines by dendritic cells from patients with rheumatoid arthritis, and down regulation upon FcgammaR triggering. Ann Rheum Dis. 2004;63:696-702 pubmed
	Libetta C, Zucchi M, Gori E, Sepe V, Galli F, Meloni F, et al. Vitamin E-loaded dialyzer resets PBMC-operated cytokine network in dialysis patients. Kidney Int. 2004;65:1473-81 pubmed
	Della Bella S, Gennaro M, Vaccari M, Ferraris C, Nicola S, Riva A, et al. Altered maturation of peripheral blood dendritic cells in patients with breast cancer. Br J Cancer. 2003;89:1463-72 pubmed
	Loffreda S, Muratori P, Muratori L, Mele L, Bianchi F, Lenzi M. Enhanced monocyte Th1 cytokine production in HCV-infected cryoglobulinemic patients. J Hepatol. 2003;38:230-6 pubmed
	McDowell M, Marovich M, Lira R, Braun M, Sacks D. Leishmania priming of human dendritic cells for CD40 ligand-induced interleukin-12p70 secretion is strain and species dependent. Infect Immun. 2002;70:3994-4001 pubmed
	Yoshida Y, Kang K, Berger M, Chen G, Gilliam A, Moser A, et al. Monocyte induction of IL-10 and down-regulation of IL-12 by iC3b deposited in ultraviolet-exposed human skin. J Immunol. 1998;161:5873-9 pubmed
	Kalinski P, Hilkens C, Snijders A, Snijdewint F, Kapsenberg M. IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cells. J Immunol. 1997;159:28-35 pubmed
	van der Pouw Kraan T, Boeije L, de Groot E, Stapel S, Snijders A, Kapsenberg M, et al. Reduced production of IL-12 and IL-12-dependent IFN-gamma release in patients with allergic asthma. J Immunol. 1997;158:5560-5 pubmed
	Libraty D, Airan L, Uyemura K, Jullien D, Spellberg B, Rea T, et al. Interferon-gamma differentially regulates interleukin-12 and interleukin-10 production in leprosy. J Clin Invest. 1997;99:336-41 pubmed
	Kremer I, Hilkens C, Sylva Steenland R, Koomen C, Kapsenberg M, Bos J, et al. Reduced IL-12 production by monocytes upon ultraviolet-B irradiation selectively limits activation of T helper-1 cells. J Immunol. 1996;157:1913-8 pubmed
	Snijders A, Hilkens C, van der Pouw Kraan T, Engel M, Aarden L, Kapsenberg M. Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocytes is determined by the expression of the p35 subunit. J Immunol. 1996;156:1207-12 pubmed
	D ANDREA A, Rengaraju M, Valiante N, Chehimi J, Kubin M, Aste M, et al. Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J Exp Med. 1992;176:1387-98 pubmed

product information

Product Type :

Antibody

Product Name :

IL-12 p70 Monoclonal Antibody (20C2)

Catalog # :

M122

Quantity :

500 µg

Price :

US 460

Clonality :

Monoclonal

Purity :

Protein G

Host :

Rat

Reactivity :

Human

Applications :

ELISA: Assay-dependent, Western Blot: Assay-dependent

Species :

Human

Clone :

20C2

Isotype :

IgG1

Storage :

-20°C

Description :

IL-12 p70, also known as interleukin-12, is a cytokine that plays a critical role in the immune system's response to infections and cancer. It is produced by immune cells, including dendritic cells, macrophages, and B cells, in response to certain pathogens and tumor cells. IL-12 p70 stimulates the production of interferon-gamma and other cytokines, which promote the activation and proliferation of T cells and natural killer cells. IL-12 p70 has been studied as a potential therapeutic target for various diseases and conditions, including infectious diseases, autoimmune disorders, and cancer. It has been shown to enhance immune responses against certain infections and tumors, and to modulate inflammatory responses in autoimmune diseases.

Immunogen :

Recombinant human IL-12 (p70)

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Western Blot: Assay-dependent

Aliases :

20C2; CLMF; CLMF p35; CLMF p40; CLMF2; cytokine; cytotoxic lymphocyte maturation factor 1, p35; cytotoxic lymphocyte maturation factor 35 kDa subunit; Cytotoxic lymphocyte maturation factor 40 kDa subunit; il 12; IL 12p70; Il12; IL-12; Il-12 p35; IL-12 p75; IL-12 subunit p35; IL-12 subunit p40; IL-12, subunit p35; IL12, subunit p40; Il-12; cytokine; IL12A; IL-12A; IL12A/B; IL12AB; IL12B; Il-12b; IL12P35; IL-12p35; Il12p40; Il-12p40; IL35 subunit; ILN; IMD28; IMD29; Interleukin; interleukin 12 35 kDa subunit; interleukin 12 35kDa subunit; interleukin 12 40 kDa subunit; interleukin 12 40kDa subunit; interleukin 12 p35 subunit; interleukin 12 p40 subunit precursor; interleukin 12 polypeptide 35; interleukin 12, p35; interleukin 12, p40; interleukin 12A; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35); interleukin 12B; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40); interleukin 12p35 subunit precursor; interleukin-12 alpha chain; interleukin-12 alpha p40 subunit; interleukin-12 beta chain; interleukin-12 beta p35 subunit; interleukin-12 p35 subunit; interleukin-12 p35 subunit precursor; interleukin-12 p40; interleukin-12 p40 subunit; interleukin-12 p40 subunit precursor; Interleukin-12 p70; interleukin-12 subunit alpha; Interleukin-12 subunit beta; interleukin-23 p40 subunit; Ll12a; MGC151228; MGC151232; natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35; natural killer cell stimulatory factor, 40 kD subunit; NF cell stimulatory factor chain 1; NFSK; NK cell stimulatory factor chain 1; NK cell stimulatory factor chain 2; NKSF; NKSF1; NKSF2; P35; p40

more info or order :

Invitrogen product webpage