TCR beta Monoclonal Antibody (H57-597), NovaFluor™ Blue 660-120S, eBioscience | Invitrogen M013T02B08 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TCR beta Monoclonal Antibody (H57-597), NovaFluor™ Blue 660-120S, eBioscience

catalog :

M013T02B08

quantity :

25 µg

price :

US 178.00

clonality :

monoclonal

host :

hamsters

conjugate :

nonconjugated

clone name :

H57-597

reactivity :

mouse

application :

flow cytometry

product information

Product Type :

Antibody

Product Name :

TCR beta Monoclonal Antibody (H57-597), NovaFluor™ Blue 660-120S, eBioscience

Catalog # :

M013T02B08

Quantity :

25 µg

Price :

US 178.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Armenian Hamster

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.8 µg/test

Species :

Mouse

Clone :

H57-597

Isotype :

IgG

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.8 µg/test

Aliases :

bTCR; FLJ22602; MGC117436; MGC22624; MGC23964; MGC71411; T cell receptor beta chain; t-cell antigen receptor; T-cell receptor; TCR beta; Tcra; Tcrb; TCRbeta; TCRD; Tib; TRA