This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Nitrotyrosine Monoclonal Antibody (1F1)
catalog :
LF-MA0225
quantity :
100 µL
price :
US 395.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
1F1
application :
western blot, ELISA, immunoprecipitation
product information
Product Type :
Antibody
Product Name :
Nitrotyrosine Monoclonal Antibody (1F1)
Catalog # :
LF-MA0225
Quantity :
100 µL
Price :
US 395.00
Clonality :
Monoclonal
Purity :
Ammonium sulfate precipitation
Host :
Mouse
Reactivity :
Chemical
Applications :
ELISA: Assay-dependent, Immunoprecipitation: 3 µL, Western Blot: 1:10,000
Species :
Chemical
Clone :
1F1
Isotype :
IgG1
Storage :
-20° C, Avoid Freeze/Thaw Cycles
Description :
Nitrotyrosine is a relatively stable product formed from various reaction pathways. Perhaps most notable is the reaction of peroxynitrite (formed from superoxide and nitric oxide (NO) radicals) with tyrosine. As a strong oxidant and nitrating agent, peroxynitrite mediates tyrosine nitration reactions on proteins resulting in inactivation of certain housekeeping enzymes (e. g., alpha1-antiproteinase) as well as endogenous antioxidant enzymes such as catalase and superoxide dismutase (SOD). Nitrotyrosine has been identified as an indicator of cell damage and inflammation, as well as of the production of NO. It is believed that measuring the concentration of nitrotyrosine will serve as a marker for damage caused by NO in the cell. Nitrotyrosine has been implicated in the pathogenesis of several inflammatory, infectious, and degenerative human diseases, such as Alzheimer's and Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis (ALS), asthma, atherosclerosis, and a variety of conditions precipitated by endothelial injury. At the protein level, tyrosine nitration can lead to loss or alteration of protein function, as demonstrated for the oncogenic protein p53 and the mitochondrial protein, manganese-dependent superoxide dismutase (MnSOD).
Immunogen :
Peroxynitrate treated BSA
Format :
Liquid
Applications w/Dilutions :
ELISA: Assay-dependent, Immunoprecipitation: 3 µL, Western Blot: 1:10,000
Aliases :
Nitro-tyrosine
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA