Human JAK2 (Phospho) [pY1007/pY1008] ELISA Kit | Invitrogen KHO5621 product information

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product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

ELISA/assay

product name :

Human JAK2 (Phospho) [pY1007/pY1008] ELISA Kit

catalog :

KHO5621

quantity :

96 Tests

price :

744 USD

product information

Product Type :

ELISA

Catalog Number :

KHO5621

Category :

ELISA Kits

Target :

JAK2

Product Name :

Human JAK2 (Phospho) [pY1007/pY1008] ELISA Kit

Description :

Janus kinase 2 (JAK2) is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways and is mutated in polycythemia vera. This kinase contains the catalytic domain (JH1) of JAK2. The activation of JAKs can lead to the phosphorylation of STAT (signal transducers and activatiors of transcription) proteins, which dimerize and translocate to the nucleus. Once translocated to the nucleus, the STAT proteins can modify transcription of numerous genes, including interferon-stimulated genes. JAK2 is required for the IFN gamma-receptor complex initiation and JAK1 functions as an amplifier. Some studies have suggested that the role of JAK2 might be performed by Tyk2 and JAK3, if they were positioned correctly within the IFN gamma-receptor complex. Mutations affecting JAK2 can cause Budd-Chiari syndrome, Polycythemia vera, Thrombocythemia 3, myelofibrosis, or Acute myelogenous leukemia.

Synonyms :

EC 2.7.10.2; Fd17; JAK 2; JAK2; JAK-2; Janus kinase 2; Janus kinase 2 (a protein tyrosine kinase); JTK 10; JTK10; kinase Jak2; THCYT3; Tyrosine-protein kinase JAK2

Price (USD) :

744 USD

Size :

96 Tests

Species Reactivity :

Human, Mouse

Applications :

ELISA

Storage :

2-8 C

Detection Range :

1.6-100 U/mL

Sample Type :

Cell Lysate, 10 µL

Assay Length :

1 hr 20 min

Note :

This product is for research use only.