Human Tau (Total) ELISA Kit | Invitrogen KHB0041 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

ELISA/assay

product name :

Human Tau (Total) ELISA Kit

catalog :

KHB0041

quantity :

96 Tests

price :

734 USD

citations: 7

Reference
Shandilya S, Kesari K, Ruokolainen J. Vitamin K2 Modulates Organelle Damage and Tauopathy Induced by Streptozotocin and Menadione in SH-SY5Y Cells. Antioxidants (Basel). 2021;10: pubmed publisher
Di J, Siddique I, Li Z, Malki G, Hornung S, Dutta S, et al. The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S-tau transgenic mice. Alzheimers Res Ther. 2021;13:6 pubmed publisher
Liu Y, Zhang S, Li X, Liu E, Wang X, Zhou Q, et al. Peripheral inflammation promotes brain tau transmission via disrupting blood-brain barrier. Biosci Rep. 2020;40: pubmed publisher
Bortolotti D, Gentili V, Rotola A, Caselli E, Rizzo R. HHV-6A infection induces amyloid-beta expression and activation of microglial cells. Alzheimers Res Ther. 2019;11:104 pubmed publisher
Shin W, Di J, Cao Q, Li B, Seidler P, Murray K, et al. Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation. Alzheimers Res Ther. 2019;11:86 pubmed publisher
Ikezu T, Chen C, Deleo A, Zeldich E, Fallin M, Kanaan N, et al. Tau Phosphorylation is Impacted by Rare AKAP9 Mutations Associated with Alzheimer Disease in African Americans. J Neuroimmune Pharmacol. 2018;13:254-264 pubmed publisher
Yan X, Nykänen N, Brunello C, Haapasalo A, Hiltunen M, Uronen R, et al. FRMD4A-cytohesin signaling modulates the cellular release of tau. J Cell Sci. 2016;129:2003-15 pubmed publisher

product information

Product Type :

ELISA

Catalog Number :

KHB0041

Category :

ELISA Kits

Target :

Tau

Product Name :

Human Tau (Total) ELISA Kit

Description :

Tau is a neuronal microtubule-associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerization and stabilize microtubules. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton while the longer isoforms may preferentially play a role in its stabilization. In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer's diseases (AD) brain. Hyper-phosphorylation impairs the microtubule binding function of Tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Numerous serine/threonine kinases phosphorylate Tau, including GSK-3beta, protein kinase A (PKA), cyclin-dependent kinase 5 (cdk5) and casein kinase II. Hyper-phosphorylated Tau is found in neurofibrillary lesions in a range and other central nervous system disorders such as Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.

Synonyms :

AI413597; AW045860; DDPAC; FLJ31424; FTDP17; FTDP-17; G protein beta1/gamma2 subunit-interacting factor 1; map tau; Mapt; MAPTL; MGC138549; microtubule associated protein tau; microtubule-associated protein tau; microtubule-associated protein tau, isoform 4; microtubules; MSTD; Mtapt; MTBT1; MTBT2; Neurofibrillary tangle protein; neurofibrillary tangles; Neuronal Marker; paired helical filament-tau; PHFtau; PHF-tau; PPND; PPP1R103; protein phosphatase 1, regulatory subunit 103; pTau; RNPTAU; Tau; Tau microtubule-associated protein; tau protein; Tau-4; Tau5; Unknown (protein for MGC:134287)

Price (USD) :

734 USD

Size :

96 Tests

Species Reactivity :

Human

Applications :

ELISA

Storage :

2-8 C

Detection Range :

31-2000 pg/mL

Sample Type :

Cerebrospinal Fluid, 50 µL Supernatant, 50 µL

Assay Length :

1 hr 20 min

Note :

This product is for research use only.