CTLA-4 Monoclonal Antibody (1B8), FITC | Invitrogen HMCD15201 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CTLA-4 Monoclonal Antibody (1B8), FITC

catalog :

HMCD15201

quantity :

500 ug

price :

US 556.00

clonality :

monoclonal

host :

hamsters

conjugate :

FITC

clone name :

1B8

reactivity :

mouse

application :

ELISA, flow cytometry, blocking or activating experiments

more info or order :

Invitrogen product webpage

citations: 4

Published Application/Species/Sample/Dilution	Reference
blocking or activating experiments; mouse; fig 1	Leach D, Krummel M, Allison J. Enhancement of antitumor immunity by CTLA-4 blockade. Science. 1996;271:1734-6 pubmed
	Hu J, He J, Wang Y, Zhao Y, Fang K, Dong Y, et al. Ultrasound combined with nanobubbles promotes systemic anticancer immunity and augments anti-PD1 efficacy. J Immunother Cancer. 2022;10: pubmed publisher
	Doo D, Meza Perez S, Londoño A, Goldsberry W, Katre A, Boone J, et al. Inhibition of the Wnt/β-catenin pathway enhances antitumor immunity in ovarian cancer. Ther Adv Med Oncol. 2020;12:1758835920913798 pubmed publisher
	Goldsberry W, Meza Perez S, Londoño A, Katre A, Mott B, Roane B, et al. Inhibiting WNT Ligand Production for Improved Immune Recognition in the Ovarian Tumor Microenvironment. Cancers (Basel). 2020;12: pubmed publisher

product information

Product Type :

Antibody

Product Name :

CTLA-4 Monoclonal Antibody (1B8), FITC

Catalog # :

HMCD15201

Quantity :

500 ug

Price :

US 556.00

Clonality :

Monoclonal

Purity :

purified

Host :

Armenian Hamster

Reactivity :

Mouse

Applications :

ELISA: 3 ug/10^6 cells, Flow Cytometry: 0.1-0.2 ug / 1x10^6 cells

Species :

Mouse

Clone :

1B8

Isotype :

IgG1

Storage :

4 C, store in dark

Description :

CTLA4 (Cytotoxic T-Lymphocyte Antigen 4) is a CD28-family receptor expressed on mainly CD4+ T cells. It binds the same ligands as CD28 (CD80 and CD86 on B cells and dendritic cells), but with higher affinity than CD28. However, in contrast to CD28 which enhances cell function when bound at the same time as the T cell receptor, CTLA4 inhbits the T cell and prevents it from functioning. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function.

Immunogen :

Mouse CD152 (CTLA-4). from Extracellular portion of murine CTLA-4 fused to a murine IgG2a

Format :

Liquid

Applications w/Dilutions :

ELISA: 3 ug/10^6 cells, Flow Cytometry: 0.1-0.2 ug / 1x10^6 cells

Aliases :

ALPS5; CD; CD152; CD152 antigen; CD152 isoform; CD152 protein; CD152 protein precursor; celiac disease 3; CELIAC3; Ctla4; CTLA-4; cytotoxic T lymphocyte associated antigen 4 short spliced form; cytotoxic T-lymphocyte associated protein 4; cytotoxic T-lymphocyte protein 4; cytotoxic T-lymphocyte protein 4 isoform CTLA4-TM; cytotoxic T-lymphocyte-associated antigen 4; cytotoxic T-lymphocyte-associated protein 4; cytotoxic T-lymphocyte-associated serine esterase-4; EGK_04712; GRD4; GSE; ICOS; IDDM12; insulin-dependent diabetes mellitus 12; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4; Ly-56; sCTLA4; soluble form; transmembrane form

more info or order :

Invitrogen product webpage