TCR beta Monoclonal Antibody (H57-597), Alexa Fluor 647 | Invitrogen HM3621 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TCR beta Monoclonal Antibody (H57-597), Alexa Fluor 647

catalog :

HM3621

quantity :

1 mL

price :

US 430.00

clonality :

monoclonal

host :

hamsters

conjugate :

AF647

clone name :

H57-597

reactivity :

mouse

application :

immunocytochemistry, flow cytometry

more info or order :

Invitrogen product webpage

citations: 3

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; loading ...; fig s1b	Coursey T, Bian F, Zaheer M, Pflugfelder S, Volpe E, de Paiva C. Age-related spontaneous lacrimal keratoconjunctivitis is accompanied by dysfunctional T regulatory cells. Mucosal Immunol. 2017;10:743-756 pubmed publisher
immunocytochemistry; mouse; fig 1	Lin W, Fan Z, Suo Y, Deng Y, Zhang M, Wang J, et al. The bullseye synapse formed between CD4+ T-cell and staphylococcal enterotoxin B-pulsed dendritic cell is a suppressive synapse in T-cell response. Immunol Cell Biol. 2015;93:99-110 pubmed publisher
	Gunnarsen K, Høydahl L, Risnes L, Dahal Koirala S, Neumann R, Bergseng E, et al. A TCRα framework-centered codon shapes a biased T cell repertoire through direct MHC and CDR3β interactions. JCI Insight. 2017;2: pubmed publisher

product information

Product Type :

Antibody

Product Name :

TCR beta Monoclonal Antibody (H57-597), Alexa Fluor 647

Catalog # :

HM3621

Quantity :

1 mL

Price :

US 430.00

Clonality :

Monoclonal

Purity :

purified

Host :

Armenian Hamster

Reactivity :

Mouse

Applications :

Flow Cytometry: Assay-dependent

Species :

Mouse

Clone :

H57-597

Isotype :

IgG

Storage :

4 C

Description :

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

Immunogen :

TCR affinity purified from mouse T cell hybridoma DO-11.101

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay-dependent

Aliases :

bTCR; FLJ22602; MGC117436; MGC22624; MGC23964; MGC71411; T cell receptor beta chain; t-cell antigen receptor; T-cell receptor; TCR beta; Tcra; Tcrb; TCRbeta; TCRD; Tib; TRA

more info or order :

Invitrogen product webpage