CD28 Monoclonal Antibody (37.51.1) | Invitrogen HM3500-5 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD28 Monoclonal Antibody (37.51.1)

catalog :

HM3500-5

quantity :

2.5 mL

price :

322 USD

clonality :

monoclonal

host :

golden hamster

conjugate :

nonconjugated

clone name :

37.51.1

reactivity :

mouse

application :

flow cytometry, blocking or activating experiments

citations: 10

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse	Raker V, Stein J, Montermann E, Maxeiner J, Taube C, Reske Kunz A, et al. Regulation of IgE production and airway reactivity by CD4â»CD8â» regulatory T cells. Immunobiology. 2015;220:490-9 pubmed publisher
blocking or activating experiments; mouse	Casiraghi F, Azzollini N, Cassis P, Imberti B, Morigi M, Cugini D, et al. Pretransplant infusion of mesenchymal stem cells prolongs the survival of a semiallogeneic heart transplant through the generation of regulatory T cells. J Immunol. 2008;181:3933-46 pubmed
blocking or activating experiments; mouse	Zoja C, Casiraghi F, Conti S, Corna D, Rottoli D, Cavinato R, et al. Cyclin-dependent kinase inhibition limits glomerulonephritis and extends lifespan of mice with systemic lupus. Arthritis Rheum. 2007;56:1629-37 pubmed
flow cytometry; mouse; fig 4	Hogg K, Kumkate S, Mountford A. IL-10 regulates early IL-12-mediated immune responses induced by the radiation-attenuated schistosome vaccine. Int Immunol. 2003;15:1451-9 pubmed
flow cytometry; mouse; fig 1	Radoja S, Saio M, Frey A. CD8+ tumor-infiltrating lymphocytes are primed for Fas-mediated activation-induced cell death but are not apoptotic in situ. J Immunol. 2001;166:6074-83 pubmed
blocking or activating experiments; mouse; 2.5 ug/ml	Gu J, Stegmann S, Gathy K, Murray R, Laliberte J, Ayscue L, et al. Inhibition of T lymphocyte activation in mice heterozygous for loss of the IMPDH II gene. J Clin Invest. 2000;106:599-606 pubmed
flow cytometry; mouse	Deeths M, Kedl R, Mescher M. CD8+ T cells become nonresponsive (anergic) following activation in the presence of costimulation. J Immunol. 1999;163:102-10 pubmed
flow cytometry; mouse; fig 1, 2	Sasaki T, Kanke Y, Kudoh K, Misawa Y, Shimizu J, Takita T. Effects of dietary docosahexaenoic acid on surface molecules involved in T cell proliferation. Biochim Biophys Acta. 1999;1436:519-30 pubmed
blocking or activating experiments; mouse	Tsujimura K, Takahashi T, Iwase S, Matsudaira Y, Kaneko Y, Yagita H, et al. Two types of anti-TL (thymus leukemia) CTL clones with distinct target specificities: differences in cytotoxic mechanisms and accessory molecule requirements. J Immunol. 1998;160:5253-61 pubmed
flow cytometry; mouse; tbl 1	Lin K, Abraham K. Targets of p56(lck) activity in immature thymoblasts: stimulation of the Ras/Raf/MAPK pathway. Int Immunol. 1997;9:291-306 pubmed

product information

Product Type :

Antibody

Product Name :

CD28 Monoclonal Antibody (37.51.1)

Catalog # :

HM3500-5

Quantity :

2.5 mL

Price :

322 USD

Clonality :

Monoclonal

Purity :

purified

Host :

Syrian Hamster

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.25-0.5 µg / 1x10^6 cells

Species :

Mouse

Clone :

37.51.1

Isotype :

IgG

Storage :

4° C

Description :

CD28 antigen is a 44 kDa disulfide linked homodimeric T cell specific surface glycoprotein. CD28 is a cell adhesion molecule of the immunoglobulin superfamily which is constitutively expressed on most peripheral blood T lymphocytes. Moreover, CD28 is the critical T cell costimulatory receptor that provides the cell the important second activation signal by binding CD80 and CD86 which are expressed by antigen presenting cells. In addition to its co-stimulation role, CD28 functions by preventing T cells from entering an anergic-hyporesponsive state or from undergoing premature apoptotic cell death. In murine peripheral lymphoid organs and in the blood, all CD4+ and CD8+ T cells express CD28. In the thymus, CD28 expression is highest on immature CD3-, CD8+ and CD4+8+ cells, and on CD4-8- cells that express alpha/beta and gamma/delta TCR. The level of CD28 on mature CD4+ and CD8+ alpha/beta TCR+ thymocytes is two- to fourfold lower than on the immature cells. Diseases associated with CD28 dysfunction include mycosis fungiodes and Sezary’s Disease.

Immunogen :

Mouse T lymphoma EL-4 cells.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.25-0.5 µg / 1x10^6 cells

Aliases :

MGC138290, Tp44, CD28 antigen, T-cell-specific surface glycoprotein CD28