CD3e Monoclonal Antibody (500A2), Cyanine5 | Invitrogen HM3411 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD3e Monoclonal Antibody (500A2), Cyanine5

catalog :

HM3411

quantity :

500µL

price :

US 233

clonality :

monoclonal

host :

golden hamster

conjugate :

Cy5

clone name :

500A2

reactivity :

mouse

application :

immunocytochemistry, flow cytometry, blocking or activating experiments, other

citations: 3

Published Application/Species/Sample/Dilution	Reference
other; mouse flow cytometry; mouse immunocytochemistry; mouse; fig 2	Koneru M, Schaer D, Monu N, Ayala A, Frey A. Defective proximal TCR signaling inhibits CD8+ tumor-infiltrating lymphocyte lytic function. J Immunol. 2005;174:1830-40 pubmed
flow cytometry; mouse	Havran W, Poenie M, Kimura J, Tsien R, Weiss A, Allison J. Expression and function of the CD3-antigen receptor on murine CD4+8+ thymocytes. Nature. 1987;330:170-3 pubmed
blocking or activating experiments; mouse; 0.5-10 ug/ml; fig 1	Harding F, McArthur J, Gross J, Raulet D, Allison J. CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature. 1992;356:607-9 pubmed

product information

Product Type :

Antibody

Product Name :

CD3e Monoclonal Antibody (500A2), Cyanine5

Catalog # :

HM3411

Quantity :

500µL

Price :

US 233

Clonality :

Monoclonal

Purity :

purified

Host :

Syrian Hamster

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.1-0.25 µg / 1x10^6 cells

Species :

Mouse

Clone :

500A2

Isotype :

IgG

Storage :

4° C

Description :

The CD3 subunit complex which is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules and this association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. The genes encoding the CD3 epsilon, gamma and delta polypeptides are located on chromosome 11. Defects in the CD3 gene are associated with CD3 immunodeficiency.

Immunogen :

C6VL-BS cell lysate

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.1-0.25 µg / 1x10^6 cells

Aliases :

FLJ18683, T3E, TCRE, CD3-epsilon, CD3e antigen, epsilon polypeptide TiT3 complex, T-cell antigen receptor complex, epsilon subunit of T3, T-cell surface antigen T3/Leu-4 epsilon chain, T-cell surface glycoprotein CD3 epsilon chain