This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD3e Monoclonal Antibody (500A2), FITC
catalog :
HM3401
quantity :
1 mL
price :
US 144
clonality :
monoclonal
host :
golden hamster
conjugate :
FITC
clone name :
500A2
reactivity :
mouse
application :
flow cytometry, blocking or activating experiments
citations: 19
| Published Application/Species/Sample/Dilution | Reference |
|---|---|
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| Peng J, Kitchen S, West R, Sigler R, Eisenmann K, Alberts A. Myeloproliferative defects following targeting of the Drf1 gene encoding the mammalian diaphanous related formin mDia1. Cancer Res. 2007;67:7565-71 pubmed
|
| Kueng H, Leb V, Haiderer D, Raposo G, Thery C, Derdak S, et al. General strategy for decoration of enveloped viruses with functionally active lipid-modified cytokines. J Virol. 2007;81:8666-76 pubmed
|
| Taylor P, Tsoni S, Willment J, Dennehy K, Rosas M, Findon H, et al. Dectin-1 is required for beta-glucan recognition and control of fungal infection. Nat Immunol. 2007;8:31-8 pubmed
|
| Chen B, Cui X, Sempowski G, Domen J, Chao N. Hematopoietic stem cell dose correlates with the speed of immune reconstitution after stem cell transplantation. Blood. 2004;103:4344-52 pubmed
|
| Makar K, Pérez Melgosa M, Shnyreva M, Weaver W, Fitzpatrick D, Wilson C. Active recruitment of DNA methyltransferases regulates interleukin 4 in thymocytes and T cells. Nat Immunol. 2003;4:1183-90 pubmed
|
| Kovalev G, Franklin D, Coffield V, Xiong Y, Su L. An important role of CDK inhibitor p18(INK4c) in modulating antigen receptor-mediated T cell proliferation. J Immunol. 2001;167:3285-92 pubmed
|
| Leite De Moraes M, Hameg A, Pacilio M, Koezuka Y, Taniguchi M, van Kaer L, et al. IL-18 enhances IL-4 production by ligand-activated NKT lymphocytes: a pro-Th2 effect of IL-18 exerted through NKT cells. J Immunol. 2001;166:945-51 pubmed
|
| Brabb T, Von Dassow P, Ordonez N, Schnabel B, Duke B, Goverman J. In situ tolerance within the central nervous system as a mechanism for preventing autoimmunity. J Exp Med. 2000;192:871-80 pubmed
|
| Masurier C, Pioche Durieu C, Colombo B, Lacave R, Lemoine F, Klatzmann D, et al. Immunophenotypical and functional heterogeneity of dendritic cells generated from murine bone marrow cultured with different cytokine combinations: implications for anti-tumoral cell therapy. Immunology. 1999;96:569-77 pubmed
|
| Clark L, Appleby M, Brunkow M, Wilkinson J, Ziegler S, Ramsdell F. Cellular and molecular characterization of the scurfy mouse mutant. J Immunol. 1999;162:2546-54 pubmed
|
| Samoilova E, Horton J, Hilliard B, Liu T, Chen Y. IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: roles of IL-6 in the activation and differentiation of autoreactive T cells. J Immunol. 1998;161:6480-6 pubmed
|
| Guttormsen H, Wetzler L, Finberg R, Kasper D. Immunologic memory induced by a glycoconjugate vaccine in a murine adoptive lymphocyte transfer model. Infect Immun. 1998;66:2026-32 pubmed
|
| Kawahara M, Suto C, Shibata S, Futohashi M, Rikihisa Y. Impaired antigen specific responses and enhanced polyclonal stimulation in mice infected with Ehrlichia muris. Microbiol Immunol. 1996;40:575-81 pubmed
|
| Pear W, Aster J, Scott M, Hasserjian R, Soffer B, Sklar J, et al. Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles. J Exp Med. 1996;183:2283-91 pubmed
|
| Havran W, Poenie M, Kimura J, Tsien R, Weiss A, Allison J. Expression and function of the CD3-antigen receptor on murine CD4+8+ thymocytes. Nature. 1987;330:170-3 pubmed
|
| Harding F, McArthur J, Gross J, Raulet D, Allison J. CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature. 1992;356:607-9 pubmed
|
product information
Product Type :
Antibody
Product Name :
CD3e Monoclonal Antibody (500A2), FITC
Catalog # :
HM3401
Quantity :
1 mL
Price :
US 144
Clonality :
Monoclonal
Purity :
purified
Host :
Syrian Hamster
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.1-0.25 µg / 1x10^6 cells
Species :
Mouse
Clone :
500A2
Isotype :
IgG
Storage :
4° C
Description :
The CD3 subunit complex which is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules and this association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. The genes encoding the CD3 epsilon, gamma and delta polypeptides are located on chromosome 11. Defects in the CD3 gene are associated with CD3 immunodeficiency.
Immunogen :
C6VL-BS cell lysate
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.1-0.25 µg / 1x10^6 cells
Aliases :
FLJ18683, T3E, TCRE, CD3-epsilon, CD3e antigen, epsilon polypeptide TiT3 complex, T-cell antigen receptor complex, epsilon subunit of T3, T-cell surface antigen T3/Leu-4 epsilon chain, T-cell surface glycoprotein CD3 epsilon chain
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com81 Wyman Street
Waltham, MA USA 02451
800-678-5599
headquarters: USA
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