Fibronectin Monoclonal Antibody (A32) | Invitrogen CSI 005-32-02 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Fibronectin Monoclonal Antibody (A32)

catalog :

CSI 005-32-02

quantity :

200 µL

price :

US 796

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

A32

reactivity :

human, bovine

application :

western blot, ELISA, immunohistochemistry, immunoprecipitation, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 3

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - frozen section; human; 1:100; loading ...; fig 3a	Degendorfer G, Chuang C, Kawasaki H, Hammer A, Malle E, Yamakura F, et al. Peroxynitrite-mediated oxidation of plasma fibronectin. Free Radic Biol Med. 2016;97:602-615 pubmed publisher
immunohistochemistry; human; 1:200 ELISA; human	Hubbard B, Buczek Thomas J, Nugent M, Smith M. Heparin-dependent regulation of fibronectin matrix conformation. Matrix Biol. 2014;34:124-31 pubmed publisher
	Gamon L, Dieterich S, Ignasiak M, Schrameyer V, Davies M. Iodide modulates protein damage induced by the inflammation-associated heme enzyme myeloperoxidase. Redox Biol. 2020;28:101331 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Fibronectin Monoclonal Antibody (A32)

Catalog # :

CSI 005-32-02

Quantity :

200 µL

Price :

US 796

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Bovine, Human

Applications :

ELISA: 1:4,000, Immunohistochemistry (Frozen): Assay dependent, Immunoprecipitation: Assay dependent, Western Blot: 1:100

Species :

Bovine, Human

Clone :

A32

Isotype :

IgG1, kappa

Storage :

4° C, store in dark

Description :

Fibronectin is a disulfide-bonded dimer with a molecular weight range of 230-250 kDa. In the extracellular matrix of several connective tissues and vessels, fibronectin is present as an insoluble protein that is extensively cross-linked by interchain disulfide bonds forming high molecular mass polymers. Fibronectin is most abundant during embryonic development and tissue remodeling. Fibronectin is also present at high concentrations as a soluble plasma protein. Fibronectin is organized as a linear series of repeating modules which form domains for interaction with fibronectin itself, other matrix components (e.g. collagen and heparin) and receptors on cells (e.g. integrins). Fibronectin is present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. Fibronectin has been implicated in carcinoma development in lung cancer. Further, Fibronectin expression is increased especially in non-small cell lung carcinoma. The adhesion of lung carcinoma cells to Fibronectin enhances tumorgenecity and confers resistance to apoptosis induced by standard chemotherapeutic agents. The gene encoding Fibronectin has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some Fibronectin variants has not been determined.

Immunogen :

Bovine corneal endothelial cells.

Format :

Liquid

Applications w/Dilutions :

ELISA: 1:4,000, Immunohistochemistry (Frozen): Assay dependent, Immunoprecipitation: Assay dependent, Western Blot: 1:100

Aliases :

Anastellin; CIG; Cold-insoluble globulin; cumulus cell-specific fibronectin 1 transcript; DKFZp686F10164; DKFZp686H0342; DKFZp686I1370; DKFZp686O13149; E330027I09; ED-B; embryo-specific fibronectin 1 transcript; ferritin L subunit; ferritin L-chain; FIBNEC; Fibronectin; fibronectin 1; fibronectin ED-A- region; fibronectin ED-B+ region; fibronectin variable region; FINC; Fn; FN1; fn-1; FNZ; GFND; GFND2; LETS; LOW QUALITY PROTEIN: fibronectin; migration-stimulating factor; MSF; Ugl-Y1; Ugl-Y2; Ugl-Y3

more info or order :

Invitrogen product webpage