Perlecan Monoclonal Antibody (A71) | Invitrogen CSI 001-71-02 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Perlecan Monoclonal Antibody (A71)

catalog :

CSI 001-71-02

quantity :

400 uL

price :

US 1112.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

A71

reactivity :

human, bovine, domestic rabbit

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 4

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; domestic rabbit; 1:150; fig 4	Santhanam A, Torricelli A, Wu J, Marino G, Wilson S. Differential expression of epithelial basement membrane components nidogens and perlecan in corneal stromal cells in vitro. Mol Vis. 2015;21:1318-27 pubmed
ELISA; human	Decarlo A, Belousova M, Ellis A, Petersen D, Grenett H, Hardigan P, et al. Perlecan domain 1 recombinant proteoglycan augments BMP-2 activity and osteogenesis. BMC Biotechnol. 2012;12:60 pubmed publisher
	Tellman T, Cruz L, Grindel B, Farach Carson M. Cleavage of the Perlecan-Semaphorin 3A-Plexin A1-Neuropilin-1 (PSPN) Complex by Matrix Metalloproteinase 7/Matrilysin Triggers Prostate Cancer Cell Dyscohesion and Migration. Int J Mol Sci. 2021;22: pubmed publisher
	Ellis A, Pan W, Yang G, Jones K, Chuang C, Whitelock J, et al. Similarity of recombinant human perlecan domain 1 by alternative expression systems bioactive heterogenous recombinant human perlecan D1. BMC Biotechnol. 2010;10:66 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Perlecan Monoclonal Antibody (A71)

Catalog # :

CSI 001-71-02

Quantity :

400 uL

Price :

US 1112.00

Clonality :

Monoclonal

Purity :

Protein A/G

Host :

Mouse

Reactivity :

Bovine, Human

Applications :

ELISA: 1:8,000, Immunohistochemistry (Frozen): Assay-dependent, Immunohistochemistry (Paraffin): Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: 1:100

Species :

Bovine, Human

Clone :

A71

Isotype :

IgG1, kappa

Storage :

4 C, store in dark

Description :

Perlecan is a major heparan-sulfate proteoglycan (HSPG) found within all basement membranes and cell surfaces. Because of its strategic location and ability to store and protect growth factors, perlecan has been strongly implicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth-promoting attributes primarily by acting as a coreceptor for basic fibroblast growth factor (FGF-2). Suppression of perlecan causes substantial inhibition of neoplastic growth and neovascularization. Thus, perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment.

Immunogen :

Bovine corneal endothelial cells.

Format :

Liquid

Applications w/Dilutions :

ELISA: 1:8,000, Immunohistochemistry (Frozen): Assay-dependent, Immunohistochemistry (Paraffin): Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: 1:100

Aliases :

AI852380; Basement membrane-specific heparan sulfate proteoglycan core protein; Endorepellin; endorepellin (domain V region); heparan sulfate proteoglycan 2; HSPG; Hspg2; LG3 peptide; LOC313641; Pcn; per; perlecan; perlecan (heparan sulfate proteoglycan 2); perlecan proteoglycan; PLC; PRCAN; RP11-132G19.2; SJA; SJS; SJS1

more info or order :

Invitrogen product webpage