CD34 Monoclonal Antibody (581), Biotin | Invitrogen CD34-581-15 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD34 Monoclonal Antibody (581), Biotin

catalog :

CD34-581-15

quantity :

500 uL

price :

US 318.00

clonality :

monoclonal

host :

mouse

conjugate :

biotin

clone name :

581

reactivity :

African green monkey, human

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 8

Published Application/Species/Sample/Dilution	Reference
flow cytometry; African green monkey; fig 1	Berenson R, Andrews R, Bensinger W, Kalamasz D, Knitter G, Buckner C, et al. Antigen CD34+ marrow cells engraft lethally irradiated baboons. J Clin Invest. 1988;81:951-5 pubmed
	Rodríguez Sevilla J, Ganan Gomez I, Ma F, Chien K, del Rey M, Loghavi S, et al. Hematopoietic stem cells with granulo-monocytic differentiation state overcome venetoclax sensitivity in patients with myelodysplastic syndromes. Nat Commun. 2024;15:2428 pubmed publisher
	Jiang Q, Isquith J, Ladel L, Mark A, Holm F, Mason C, et al. Inflammation-driven deaminase deregulation fuels human pre-leukemia stem cell evolution. Cell Rep. 2021;34:108670 pubmed publisher
	Lee J, Breton G, Oliveira T, Zhou Y, Aljoufi A, PUHR S, et al. Restricted dendritic cell and monocyte progenitors in human cord blood and bone marrow. J Exp Med. 2015;212:385-99 pubmed publisher
	Breton G, Lee J, Zhou Y, Schreiber J, Keler T, PUHR S, et al. Circulating precursors of human CD1c+ and CD141+ dendritic cells. J Exp Med. 2015;212:401-13 pubmed publisher
	Li J, Lu S, Yang S, Xing W, Feng J, Li W, et al. Impaired immunomodulatory ability of bone marrow mesenchymal stem cells on CD4(+) T cells in aplastic anemia. Results Immunol. 2012;2:142-7 pubmed publisher
	Calvo J, Benyoucef A, Baijer J, Rouyez M, Pflumio F. Assessment of human multi-potent hematopoietic stem/progenitor cell potential using a single in vitro screening system. PLoS ONE. 2012;7:e50495 pubmed publisher
	Son H, Jeong Y, Kim J, Chung M. Phyllodes tumor of the seminal vesicle: case report and literature review. Pathol Int. 2004;54:924-9 pubmed

product information

Product Type :

Antibody

Product Name :

CD34 Monoclonal Antibody (581), Biotin

Catalog # :

CD34-581-15

Quantity :

500 uL

Price :

US 318.00

Clonality :

Monoclonal

Purity :

purified

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 5 uL for 1x10^6 cells

Species :

Human

Clone :

581

Isotype :

IgG1

Storage :

4 C

Description :

CD34 is a highly glycosylated monomeric with a molecular weight range of 111-115 kDa surface protein that is present on many stem cell populations. CD34 is a stem cell marker although its expression on human hematopoietic stem cells is reversible. CD34 may serve as a surface receptor that undergoes receptor-mediated endocytosis and regulates adhesion, differentiation and proliferation of hematopoietic stem cells and other progenitors. CD34 expression is likely to represent a specific state of hematopoietic development that may have altered adhering properties with expanding and differentiating capabilities in both in vitro and in vivo conditions. CD34 is possibly an adhesion molecule with a putative role for mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Further, CD34 could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. CD34 is thought to have a role in presenting carbohydrate ligands to selectins. The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C suggesting a putative role in signal transduction. Diseases associated with CD34 dysfunction include dermatofibrosarcoma and neurofibroma.

Immunogen :

Human CD34.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 uL for 1x10^6 cells

Aliases :

(E3-independent) E2 ubiquitin-conjugating enzyme R1; AU040960; CD34; CD34 antigen; CD34 molecule; CDC34; cell division cycle 34; cell division cycle 34 homolog; cluster designation 34; cluster of differentiation antigen 34; E2 ubiquitin-conjugating enzyme R1; E2-CDC34; hematopoietic progenitor cell antigen CD34; hematopoietic progenitor cell marker CD34; Mucosialin; RP11-328D5.2; sialomucin protein; type 1 transmembrane protein; UBC3; UBCH3; UBE2R1; ubiquitin carrier protein; ubiquitin conjugating enzyme E2 R1; ubiquitin-conjugating enzyme E2 R1; Ubiquitin-conjugating enzyme E2-32 kDa complementing; ubiquitin-conjugating enzyme E2-CDC34; Ubiquitin-protein ligase R1

more info or order :

Invitrogen product webpage