CD31 (PECAM-1) Monoclonal Antibody (Gi18), eBioscience | Invitrogen BMS137 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD31 (PECAM-1) Monoclonal Antibody (Gi18), eBioscience

catalog :

BMS137

quantity :

100 ug

price :

US 258.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

Gi18

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

citations: 2

Reference
Jalili Firoozinezhad S, Prantil Baun R, Jiang A, Potla R, Mammoto T, Weaver J, et al. Modeling radiation injury-induced cell death and countermeasure drug responses in a human Gut-on-a-Chip. Cell Death Dis. 2018;9:223 pubmed publisher
Newton J, Buckley C, Jones E, Simmons D. Residues on both faces of the first immunoglobulin fold contribute to homophilic binding sites of PECAM-1/CD31. J Biol Chem. 1997;272:20555-63 pubmed

product information

Product Type :

Antibody

Product Name :

CD31 (PECAM-1) Monoclonal Antibody (Gi18), eBioscience

Catalog # :

BMS137

Quantity :

100 ug

Price :

US 258.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

ELISA: Assay-Dependent, Flow Cytometry: Assay-Dependent, Immunocytochemistry: 5 ug/mL, Immunohistochemistry (Frozen): 30 ug/mL, Immunohistochemistry (Paraffin): 30 ug/mL, Western Blot: 3-30 ug/mL

Species :

Human

Clone :

Gi18

Isotype :

IgG1

Storage :

4 C

Description :

CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. It is one of key regulatory molecules in vascular system.

Immunogen :

Rec. Human CD31 (PECAM-1)

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-Dependent, Flow Cytometry: Assay-Dependent, Immunocytochemistry: 5 ug/mL, Immunohistochemistry (Frozen): 30 ug/mL, Immunohistochemistry (Paraffin): 30 ug/mL, Western Blot: 3-30 ug/mL

Aliases :

C85791; CD31; CD31 antigen; CD31, PECAM-1; CD31/EndoCAM; endoCAM; GPIIA'; I79_008304; PECA1; Pecam; PECAM1; Pecam-1; platelet and endothelial cell adhesion molecule 1; platelet endothelial cell adhesion molecule; platelet endothelial cell adhesion molecule-1; platelet/endothelial cell adhesion molecule (CD31 antigen); platelet/endothelial cell adhesion molecule 1; type I transmembrane endothelial adhesion molecule