CD44var (v6) Monoclonal Antibody (VFF-18), eBioscience | Invitrogen BMS125 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD44var (v6) Monoclonal Antibody (VFF-18), eBioscience

catalog :

BMS125

quantity :

100 µg

price :

US 231

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

VFF-18

reactivity :

human

application :

western blot, immunohistochemistry, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 11

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; 1:100; fig 1	Santhana Kumar K, Tripolitsioti D, Ma M, GrÃ¤hlert J, Egli K, Fiaschetti G, et al. The Ser/Thr kinase MAP4K4 drives c-Met-induced motility and invasiveness in a cell-based model of SHH medulloblastoma. Springerplus. 2015;4:19 pubmed publisher
	Goldstein L, Mansutti M, Levy C, Chang J, Henry S, Fernández Pérez I, et al. A randomized, placebo-controlled phase 2 study of paclitaxel in combination with reparixin compared to paclitaxel alone as front-line therapy for metastatic triple-negative breast cancer (fRida). Breast Cancer Res Treat. 2021;190:265-275 pubmed publisher
	Jowett G, Norman M, Yu T, Rosell Arévalo P, Hoogland D, Lust S, et al. ILC1 drive intestinal epithelial and matrix remodelling. Nat Mater. 2021;20:250-259 pubmed publisher
	Huang L, Bockorny B, Paul I, Akshinthala D, Frappart P, Gandarilla O, et al. PDX-derived organoids model in vivo drug response and secrete biomarkers. JCI Insight. 2020;5: pubmed publisher
	Loh T, Moon H, Cho S, Jang H, Liu Y, Tai H, et al. CD44 alternative splicing and hnRNP A1 expression are associated with the metastasis of breast cancer. Oncol Rep. 2015;34:1231-8 pubmed publisher
	Casucci M, Nicolis Di Robilant B, Falcone L, Camisa B, Norelli M, Genovese P, et al. CD44v6-targeted T cells mediate potent antitumor effects against acute myeloid leukemia and multiple myeloma. Blood. 2013;122:3461-72 pubmed publisher
	Vermeulen J, van der Wall E, Witkamp A, van Diest P. Analysis of expression of membrane-bound tumor markers in ductal carcinoma in situ of the breast: paving the way for molecular imaging. Cell Oncol (Dordr). 2013;36:333-40 pubmed publisher
	Zeilstra J, Joosten S, van Andel H, Tolg C, Berns A, Snoek M, et al. Stem cell CD44v isoforms promote intestinal cancer formation in Apc(min) mice downstream of Wnt signaling. Oncogene. 2014;33:665-70 pubmed publisher
	Vermeulen J, van Brussel A, Adams A, Mali W, van der Wall E, van Diest P, et al. Near-infrared fluorescence molecular imaging of ductal carcinoma in situ with CD44v6-specific antibodies in mice: a preclinical study. Mol Imaging Biol. 2013;15:290-8 pubmed publisher
	Girbl T, Hinterseer E, Grössinger E, Asslaber D, Oberascher K, Weiss L, et al. CD40-mediated activation of chronic lymphocytic leukemia cells promotes their CD44-dependent adhesion to hyaluronan and restricts CCL21-induced motility. Cancer Res. 2013;73:561-70 pubmed publisher
	Vermeulen J, van Brussel A, van der Groep P, Morsink F, Bult P, van der Wall E, et al. Immunophenotyping invasive breast cancer: paving the road for molecular imaging. BMC Cancer. 2012;12:240 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD44var (v6) Monoclonal Antibody (VFF-18), eBioscience

Catalog # :

BMS125

Quantity :

100 µg

Price :

US 231

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: Assay-Dependent, Immunohistochemistry (Paraffin): Assay-Dependent, Western Blot: Assay-Dependent

Species :

Human

Clone :

VFF-18

Isotype :

IgG1

Storage :

-20°C

Description :

CD44 cell surface antigen is a 100kDa glycoprotein widely expressed on human leucocytes, white matter of the brain and by some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues. CD44 is a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, cell adhesion and migration. CD44 also participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing. CD44 expression may be up-regulated upon some carcinomas, and it has been speculated that this may be related to metastatic potential.

Immunogen :

Rec. Human CD44var (v6)

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay-Dependent, Immunohistochemistry (Paraffin): Assay-Dependent, Western Blot: Assay-Dependent

Aliases :

AL133330.1; AU023126; AW121933; AW146109; CD44; CD44 antigen; CD44 molecule (Indian blood group); CD44 splice variant; CD44 V6; CD44 var; CD44 variant; CD44v6; CD44var (v6); CDW44; cell surface glycoprotein CD44; chondroitin sulfate proteoglycan 8; CSPG8; ECMRIII; ECMR-III; epican; Extracellular matrix receptor III; GP90 lymphocyte homing/adhesion receptor; HCELL; hematopoietic cell E- and L-selectin ligand; heparan sulfate proteoglycan; HERMES; Hermes antigen; homing function and Indian blood group system; HUTCHI; HUTCH-I; Hyaluronate receptor; IN; LHR; Ly-24; Lymphocyte antigen 24; MC56; MDU2; MDU3; MGC10468; MIC4; MUTCH-I; PGP I; Pgp1; Pgp-1; PGP-I; Phagocytic glycoprotein 1; phagocytic glycoprotein I; soluble CD44

more info or order :

Invitrogen product webpage