Bcl-2 Monoclonal Antibody (Bcl-2/100), eBioscience | Invitrogen BMS1028 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Bcl-2 Monoclonal Antibody (Bcl-2/100), eBioscience

catalog :

BMS1028

quantity :

100 ug

price :

US 366.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

Bcl-2/100

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 7

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; 1:500; fig 1, 2, 3	Cheuk W, Tam F, Chan A, Luk I, Yuen A, Chan W, et al. Idiopathic cervical fibrosis--a new member of IgG4-related sclerosing diseases: report of 4 cases, 1 complicated by composite lymphoma. Am J Surg Pathol. 2010;34:1678-85 pubmed publisher
	Marwarha G, R xf8 sand x, Slagsvold K, H xf8 ydal M. GSK3β Inhibition Is the Molecular Pivot That Underlies the Mir-210-Induced Attenuation of Intrinsic Apoptosis Cascade during Hypoxia. Int J Mol Sci. 2022;23: pubmed publisher
	Zhang S, Yu H, Li J, Fan J, Chen J. 2-Methoxyestradiol combined with ascorbic acid facilitates the apoptosis of chronic myeloid leukemia cells via the microRNA-223/Fms-like tyrosine kinase 3/phosphatidylinositol-3 kinase/protein kinase B axis. Bioengineered. 2022;13:3470-3485 pubmed publisher
	Walker Z, Idler B, Davis L, Stevens B, VanWyngarden M, Ohlstrom D, et al. Exploiting Protein Translation Dependence in Multiple Myeloma with Omacetaxine-Based Therapy. Clin Cancer Res. 2021;27:819-830 pubmed publisher
	Saunders I, Mir H, Kapur N, Singh S. Emodin inhibits colon cancer by altering BCL-2 family proteins and cell survival pathways. Cancer Cell Int. 2019;19:98 pubmed publisher
	Cummins N, Sainski Nguyen A, Natesampillai S, Aboulnasr F, Kaufmann S, Badley A. Maintenance of the HIV Reservoir Is Antagonized by Selective BCL2 Inhibition. J Virol. 2017;91: pubmed publisher
	Zhang S, Li Y, He X, Dong S, Huang Y, Li X, et al. Photothermolysis mediated by gold nanorods modified with EGFR monoclonal antibody induces Hep-2 cells apoptosis in vitro and in vivo. Int J Nanomedicine. 2014;9:1931-46 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Bcl-2 Monoclonal Antibody (Bcl-2/100), eBioscience

Catalog # :

BMS1028

Quantity :

100 ug

Price :

US 366.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

ELISA: Assay-Dependent, Flow Cytometry: Assay-Dependent, Immunohistochemistry: Assay-Dependent, Western Blot: 1:500

Species :

Human

Clone :

Bcl-2/100

Isotype :

IgG1, kappa

Storage :

-20 C

Description :

BCL-2 is a key regulator of apoptosis that functions to either inhibit or promote cell death. The BCL-2 family members are also characterized by dimerizing to further modulate apoptosis. Bag1, for example, has been found to form a heterodimer with BCL-2 resulting in the enhancement of the anti-apoptotic effect of BCL-2. Bax and Bak have been shown to play a critical role in cytochrome c release from mitochondria and thus initiate apoptosis. Bax exerts a pro-apoptotic rather than an anti-apoptotic effect on cells. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. In most follicular lymphomas, neoplastic germinal centers express high levels of BCL-2 alpha protein, whereas the normal or hyperplastic germinal centers are negative. Two transcript variants of BCL-2, produced by alternate splicing, differ in their C-terminal ends. The overexpression of BCL-2 has been linked to human cancers such as B-cell lymphoma and prostate cancer.

Immunogen :

Rec. Human Bcl-2

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-Dependent, Flow Cytometry: Assay-Dependent, Immunohistochemistry: Assay-Dependent, Western Blot: 1:500

Aliases :

apoptosis regulator Bcl-2; AW986256; B cell leukemia/lymphoma 2; B cell lymphoma 2 associated oncogene; B-cell CLL/lymphoma 2; B-cell leukemia/lymphoma 2; Bcl 2; BCL2; bcl-2; BCL2 apoptosis regulator; Bcl-2 protein; BCL2, apoptosis regulator; Bcl2-like protein; C430015F12Rik; D630044D05Rik; D830018M01Rik; OTTHUMP00000163680; PPP1R50; protein phosphatase 1, regulatory subunit 50

more info or order :

Invitrogen product webpage