This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
BrdU Monoclonal Antibody (MoBU-1)
catalog :
B35141
quantity :
100 Tests
price :
US 446.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
MoBu-1
application :
immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - free floating section
citations: 30
Reference
Hayakawa T, Yamamoto A, Yoneda T, Hori S, Okochi N, Kagotani K, et al. Reorganization of the DNA replication landscape during adipogenesis is closely linked with adipogenic gene expression. J Cell Sci. 2023;136: pubmed publisher
Zhao H, Haddad G. Alzheimer's disease like neuropathology in Down syndrome cortical organoids. Front Cell Neurosci. 2022;16:1050432 pubmed publisher
Yin W, Liontos A, Koepke J, Ghoul M, Mazzocchi L, Liu X, et al. An essential function for autocrine hedgehog signaling in epithelial proliferation and differentiation in the trachea. Development. 2022;149: pubmed publisher
Kim C, Jin J, Ye Z, Jadhav R, Gustafson C, Hu B, et al. Histone deficiency and accelerated replication stress in T cell aging. J Clin Invest. 2021;131: pubmed publisher
Chen C, Kawasumi M, Lan T, Poon C, Lin Y, Wu P, et al. Adaptation to Endoplasmic Reticulum Stress Enhances Resistance of Oral Cancer Cells to Cisplatin by Up-Regulating Polymerase η and Increasing DNA Repair Efficiency. Int J Mol Sci. 2020;22: pubmed publisher
Sandoval M, Ying Z, Beronja S. Interplay of opposing fate choices stalls oncogenic growth in murine skin epithelium. elife. 2021;10: pubmed publisher
Rodríguez Martínez M, Hills S, Diffley J, Svejstrup J. Multiplex Cell Fate Tracking by Flow Cytometry. Methods Protoc. 2020;3: pubmed publisher
Hung K, Sidorova J, Nghiem P, Kawasumi M. The 6-4 photoproduct is the trigger of UV-induced replication blockage and ATR activation. Proc Natl Acad Sci U S A. 2020;117:12806-12816 pubmed publisher
Morales Torres C, Wu M, Hobor S, Wainwright E, Martin M, Patel H, et al. Selective inhibition of cancer cell self-renewal through a Quisinostat-histone H1.0 axis. Nat Commun. 2020;11:1792 pubmed publisher
Schoof M, Launspach M, Holdhof D, Nguyen L, Engel V, Filser S, et al. The transcriptional coactivator and histone acetyltransferase CBP regulates neural precursor cell development and migration. Acta Neuropathol Commun. 2019;7:199 pubmed publisher
Roy A, Ghosh A, Kumar B, Chandran B. IFI16, a nuclear innate immune DNA sensor, mediates epigenetic silencing of herpesvirus genomes by its association with H3K9 methyltransferases SUV39H1 and GLP. elife. 2019;8: pubmed publisher
Arreal L, Piva M, Fernandez S, Revandkar A, Schaub Clerigué A, Villanueva J, et al. Targeting PML in triple negative breast cancer elicits growth suppression and senescence. Cell Death Differ. 2019;: pubmed publisher
Perl A, O Connor C, Fa P, Mayca Pozo F, Zhang J, Zhang Y, et al. Protein phosphatase 2A controls ongoing DNA replication by binding to and regulating cell division cycle 45 (CDC45). J Biol Chem. 2019;294:17043-17059 pubmed publisher
Huycke T, Miller B, Gill H, Nerurkar N, Sprinzak D, Mahadevan L, et al. Genetic and Mechanical Regulation of Intestinal Smooth Muscle Development. Cell. 2019;179:90-105.e21 pubmed publisher
James K, Cosway E, LUCAS B, White A, Parnell S, Carvalho Gaspar M, et al. Endothelial cells act as gatekeepers for LTβR-dependent thymocyte emigration. J Exp Med. 2018;215:2984-2993 pubmed publisher
Disson O, Blériot C, Jacob J, Serafini N, Dulauroy S, Jouvion G, et al. Peyer's patch myeloid cells infection by Listeria signals through gp38+ stromal cells and locks intestinal villus invasion. J Exp Med. 2018;215:2936-2954 pubmed publisher
Valcarcel Jimenez L, Macchia A, Martin Martin N, Cortazar A, Schaub Clerigué A, Pujana Vaquerizo M, et al. Integrative analysis of transcriptomics and clinical data uncovers the tumor-suppressive activity of MITF in prostate cancer. Cell Death Dis. 2018;9:1041 pubmed publisher
Chen C, Zhai S, Zhang L, Chen J, Long X, Qin J, et al. Uhrf1 regulates germinal center B cell expansion and affinity maturation to control viral infection. J Exp Med. 2018;215:1437-1448 pubmed publisher
Mayer C, Gazumyan A, Kara E, Gitlin A, Golijanin J, Viant C, et al. The microanatomic segregation of selection by apoptosis in the germinal center. Science. 2017;358: pubmed publisher
Kumagai A, Dunphy W. MTBP, the partner of Treslin, contains a novel DNA-binding domain that is essential for proper initiation of DNA replication. Mol Biol Cell. 2017;28:2998-3012 pubmed publisher
Fan Y, Mok C, Chan M, Zhang Y, Nal B, Kien F, et al. Cell Cycle-independent Role of Cyclin D3 in Host Restriction of Influenza Virus Infection. J Biol Chem. 2017;292:5070-5088 pubmed publisher
Zimmermann M, Arachchige Don A, Donaldson M, Patriarchi T, Horne M. Cyclin G2 promotes cell cycle arrest in breast cancer cells responding to fulvestrant and metformin and correlates with patient survival. Cell Cycle. 2016;15:3278-3295 pubmed
Al Taweel F, Douglas C, Whawell S. The Periodontal Pathogen Porphyromonas gingivalis Preferentially Interacts with Oral Epithelial Cells in S Phase of the Cell Cycle. Infect Immun. 2016;84:1966-1974 pubmed publisher
Lo C, Weil B, Palka B, Momeni A, Canty J, Neelamegham S. Cell surface glycoengineering improves selectin-mediated adhesion of mesenchymal stem cells (MSCs) and cardiosphere-derived cells (CDCs): Pilot validation in porcine ischemia-reperfusion model. Biomaterials. 2016;74:19-30 pubmed publisher
Jiang Q, Paramasivam M, Aressy B, Wu J, Bellani M, Tong W, et al. MERIT40 cooperates with BRCA2 to resolve DNA interstrand cross-links. Genes Dev. 2015;29:1955-68 pubmed publisher
Shen Z, Stanger B. YAP regulates S-phase entry in endothelial cells. PLoS ONE. 2015;10:e0117522 pubmed publisher
Holder G, McGary C, Johnson E, Zheng R, John V, Sugimoto C, et al. Expression of the mannose receptor CD206 in HIV and SIV encephalitis: a phenotypic switch of brain perivascular macrophages with virus infection. J Neuroimmune Pharmacol. 2014;9:716-26 pubmed publisher
Clewell R, Sun B, Adeleye Y, Carmichael P, Efremenko A, McMullen P, et al. Profiling dose-dependent activation of p53-mediated signaling pathways by chemicals with distinct mechanisms of DNA damage. Toxicol Sci. 2014;142:56-73 pubmed publisher
Yu H, Pak H, Hammond Martel I, Ghram M, Rodrigue A, Daou S, et al. Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair. Proc Natl Acad Sci U S A. 2014;111:285-90 pubmed publisher
Alunni A, Krecsmarik M, Bosco A, Galant S, Pan L, Moens C, et al. Notch3 signaling gates cell cycle entry and limits neural stem cell amplification in the adult pallium. Development. 2013;140:3335-47 pubmed publisher
product information
Product Type :
Antibody
Product Name :
BrdU Monoclonal Antibody (MoBU-1)
Catalog # :
B35141
Quantity :
100 Tests
Price :
US 446.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Chemical
Applications :
Flow Cytometry: Assay-dependent
Species :
Chemical
Clone :
MoBU-1
Isotype :
IgG
Storage :
4 C
Description :
Bromodeoxyuridine (5-bromo-2-deoxyuridine, BrdU) is a synthetic nucleoside that is an analogue of thymidine. BrdU is commonly used in the detection of proliferating cells in living tissues, and can be incorporated into the newly synthesized DNA of replicating cells (during the S phase of the cell cycle), substituting for thymidine during DNA replication. Antibodies specific for BrdU can then be used to detect the incorporated chemical, thus indicating cells that were actively replicating their DNA. Binding of the antibody requires denaturation of the DNA, usually by exposing the cells to acid or heat.
Immunogen :
BrdU
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: Assay-dependent
Aliases :
5-Bromo-2-deoxyuridine; Bromodeoxyuridine
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA