IL-10 Monoclonal Antibody (2G101H7) | Invitrogen ARC9102 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IL-10 Monoclonal Antibody (2G101H7)

catalog :

ARC9102

quantity :

500 µg

price :

US 375.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2G101H7

reactivity :

rat

application :

western blot, flow cytometry

more info or order :

Invitrogen product webpage

citations: 6

Published Application/Species/Sample/Dilution	Reference
western blot; rat; fig 6	Galicia Moreno M, Favari L, Muriel P. Trolox mitigates fibrosis in a bile duct ligation model. Fundam Clin Pharmacol. 2013;27:308-18 pubmed publisher
	Aiello S, Rocchetta F, Longaretti L, Faravelli S, Todeschini M, Cassis L, et al. Extracellular vesicles derived from T regulatory cells suppress T cell proliferation and prolong allograft survival. Sci Rep. 2017;7:11518 pubmed publisher
	Casas Grajales S, Vázquez Flores L, Ramos Tovar E, Hernández Aquino E, Flores Beltrán R, Cerda García Rojas C, et al. Quercetin reverses experimental cirrhosis by immunomodulation of the proinflammatory and profibrotic processes. Fundam Clin Pharmacol. 2017;31:610-624 pubmed publisher
	Hernández Aquino E, Zarco N, Casas Grajales S, Ramos Tovar E, Flores Beltrán R, Arauz J, et al. Naringenin prevents experimental liver fibrosis by blocking TGFβ-Smad3 and JNK-Smad3 pathways. World J Gastroenterol. 2017;23:4354-4368 pubmed publisher
	Galicia Moreno M, Favari L, Muriel P. Antifibrotic and antioxidant effects of N-acetylcysteine in an experimental cholestatic model. Eur J Gastroenterol Hepatol. 2012;24:179-85 pubmed publisher
	Chen K, Hsu L, Goto S, Yeh C, Nakano T, Lai C, et al. Adaptor protein Shc acts as an immune-regulator for the LPS-stimulated maturation of bone marrow-derived dendritic cells. BMC Immunol. 2011;12:32 pubmed publisher

product information

Product Type :

Antibody

Product Name :

IL-10 Monoclonal Antibody (2G101H7)

Catalog # :

ARC9102

Quantity :

500 µg

Price :

US 375.00

Clonality :

Monoclonal

Purity :

purified

Host :

Mouse

Reactivity :

Rat

Applications :

Flow Cytometry: Assay-dependent, Western Blot: Assay-dependent

Species :

Rat

Clone :

2G101H7

Isotype :

IgG1

Storage :

-20°C

Description :

Interleukin 10 (IL-10, CSIF) is an anti-inflammatory cytokine mainly produced by macrophages and Th2 cells. IL-10 is an 18.6 kDa protein of 160 amino acid residues that shares over 80% sequence homology with the Epstein-Barr Virus protein (BCRFI). The reported biological activities of IL-10, which maybe interrelated, include inhibition of macrophage-mediated cytokine synthesis, suppression of the delayed-type hyper-sensitivity response, and stimulation of the Th2 cell response which results in elevated antibody production. IL-10 functions by inhibiting pro-inflammatory cytokines made by macrophages and regulatory T cells including IFN-gamma, TNF-alpha, IL-2, and IL-3, IL-4, and GM-CSF. IL-10 is also known to suppress antigen presentation on antigen presenting cells, enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. While human IL-10 can act on murine cells, murine IL-10 cannot act on human cells. Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). IL-10 inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Knockout studies in mice suggest the function of this cytokine as an essential immunoregulator in the intestinal tract.

Immunogen :

Recombinant rat IL-10.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay-dependent, Western Blot: Assay-dependent

Aliases :

CSIF; cytokine; Cytokine synthesis inhibitory factor; GVHDS; H-IL-10; il 10; IL10; IL-10; IL-10 precursor; IL10A; IL10X; ILN; Interleukin; interleukin 10; Interleukin10; interleukin-10; MGC126450; MGC126451; RP11-262N9.1; T-cell growth inhibitory factor; TGIF

more info or order :

Invitrogen product webpage