TNF alpha Polyclonal Antibody | Invitrogen ARC3012 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TNF alpha Polyclonal Antibody

catalog :

ARC3012

quantity :

500 ug

price :

US 451.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

rat

application :

western blot

citations: 9

Reference
Walladbegi J, Dankis M, Aydogdu x, Jontell M, Winder M. Moderate temperature reduction is sufficient for prevention of 5-fluorouracil-induced oral mucositis: an experimental in vivo study in rats. Cancer Chemother Pharmacol. 2023;91:67-75 pubmed publisher
Hong Y, Lee E, Park K, Han M, Kim K, Park J. Ultrasound stimulation improves inflammatory resolution, neuroprotection, and functional recovery after spinal cord injury. Sci Rep. 2022;12:3636 pubmed publisher
Reynolds J, Henwood M, Turtle J, Baine R, Johnston D, Grau J. Brain-Dependent Processes Fuel Pain-Induced Hemorrhage After Spinal Cord Injury. Front Syst Neurosci. 2019;13:44 pubmed publisher
Martin K, Parvin S, Garraway S. Peripheral inflammation accelerates the onset of mechanical hypersensitivity after spinal cord injury and engages TNFα signaling mechanisms. J Neurotrauma. 2018;: pubmed publisher
Li M, Liu F, Sang M, Sun X, Li L, Wang X. Effects of atorvastatin on p38 phosphorylation and cardiac remodeling after myocardial infarction in rats. Exp Ther Med. 2018;16:751-757 pubmed publisher
Turtle J, Strain M, Reynolds J, Huang Y, Lee K, Henwood M, et al. Pain Input After Spinal Cord Injury (SCI) Undermines Long-Term Recovery and Engages Signal Pathways That Promote Cell Death. Front Syst Neurosci. 2018;12:27 pubmed publisher
Kao C, Chen W, Guo B, Feng C, Hung H, Yang W, et al. The 1-Tosylpentan-3-one Protects against 6-Hydroxydopamine-Induced Neurotoxicity. Int J Mol Sci. 2017;18: pubmed publisher
Chen W, Chen C, Chen N, Sung C, Wen Z. Neuroprotective Effects of Direct Intrathecal Administration of Granulocyte Colony-Stimulating Factor in Rats with Spinal Cord Injury. CNS Neurosci Ther. 2015;21:698-707 pubmed publisher
Huang S, Sung C, Chen W, Chen C, Feng C, Yang S, et al. Involvement of phosphatase and tensin homolog deleted from chromosome 10 in rodent model of neuropathic pain. J Neuroinflammation. 2015;12:59 pubmed publisher

product information

Product Type :

Antibody

Product Name :

TNF alpha Polyclonal Antibody

Catalog # :

ARC3012

Quantity :

500 ug

Price :

US 451.00

Clonality :

Polyclonal

Purity :

Protein A/G

Host :

Rabbit

Reactivity :

Rat

Applications :

Western Blot: Assay-dependent

Species :

Rat

Isotype :

IgG

Storage :

-20 C

Description :

TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophage and bind to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions. Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis when injected into tumor-bearing mice. Other functions of TNF-alpha include its role in the immune response to bacterial, viral, parasitic and certain fungal infections, as well as its role in the necrosis of specific tumors. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.

Immunogen :

Purified recombinant rat TNF- .

Format :

Liquid

Applications w/Dilutions :

Western Blot: Assay-dependent

Aliases :

APC1 protein; Cachectin; C-domain 1; C-domain 2; cTNF; DADB-70P7.1; DIF; ICD1; ICD2; Intracellular domain 1; Intracellular domain 2; N-terminal fragment; NTF; RATTNF; Tnf; TNF alpha; TNF superfamily; TNF a; TNF, macrophage-derived; TNF, monocyte-derived; TNFA; TNF-a; TNFalpha; TNF-alpha; Tnfsf1a; TNFSF2; TNFa; TNLG1F; Tumor necrosis factor; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; tumor necrosis factor alpha (cachetin); tumor necrosis factor alpha precursor; tumor necrosis factor ligand 1F; tumor necrosis factor ligand superfamily member 2; Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form; tumor necrosis factor-alpha; tumor necrosis factor-alpha precursor; tumor-necrosis factor; tumour necrosis factor