IL-6 Monoclonal Antibody (10 E5) | Invitrogen ARC0962 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IL-6 Monoclonal Antibody (10 E5)

catalog :

ARC0962

quantity :

500 µg

price :

US 375.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

10 E5

reactivity :

rat

application :

western blot, flow cytometry, blocking or activating experiments

more info or order :

Invitrogen product webpage

citations: 6

Published Application/Species/Sample/Dilution	Reference
blocking or activating experiments; rat; 5 ug/ml	Leibinger M, Muller A, Gobrecht P, Diekmann H, Andreadaki A, Fischer D. Interleukin-6 contributes to CNS axon regeneration upon inflammatory stimulation. Cell Death Dis. 2013;4:e609 pubmed publisher
western blot; rat; fig 7	Galicia Moreno M, Favari L, Muriel P. Antifibrotic and antioxidant effects of N-acetylcysteine in an experimental cholestatic model. Eur J Gastroenterol Hepatol. 2012;24:179-85 pubmed publisher
western blot; rat; fig 5	Galicia Moreno M, Favari L, Muriel P. Trolox mitigates fibrosis in a bile duct ligation model. Fundam Clin Pharmacol. 2013;27:308-18 pubmed publisher
	Ramos Tovar E, Hernández Aquino E, Casas Grajales S, Buendia Montaño L, Galindo Gómez S, Camacho J, et al. Stevia Prevents Acute and Chronic Liver Injury Induced by Carbon Tetrachloride by Blocking Oxidative Stress through Nrf2 Upregulation. Oxid Med Cell Longev. 2018;2018:3823426 pubmed publisher
	Dubovy P, Brazda V, Klusáková I, Hradilová Svíženská I. Bilateral elevation of interleukin-6 protein and mRNA in both lumbar and cervical dorsal root ganglia following unilateral chronic compression injury of the sciatic nerve. J Neuroinflammation. 2013;10:55 pubmed publisher
	Rivera H, Morales Ríos M, Bautista W, Shibayama M, Tsutsumi V, Muriel P, et al. A novel fluorinated stilbene exerts hepatoprotective properties in CCl(4)-induced acute liver damage. Can J Physiol Pharmacol. 2011;89:759-66 pubmed publisher

product information

Product Type :

Antibody

Product Name :

IL-6 Monoclonal Antibody (10 E5)

Catalog # :

ARC0962

Quantity :

500 µg

Price :

US 375.00

Clonality :

Monoclonal

Purity :

purified

Host :

Mouse

Reactivity :

Rat

Applications :

Flow Cytometry: Assay-dependent, Western Blot: Assay-dependent

Species :

Rat

Clone :

10 E5

Isotype :

IgG2b

Storage :

-20°C

Description :

Interleukin 6 (IL-6) is a multifunctional 26 kD protein originally discovered in the medium of RNA-stimulated fibroblastoid cells. IL-6 appears to be directly involved in the responses that occur after infection and cellular injury, and it may prove to be important as IL-1 and TNF-a in regulating the acute phase response. IL-6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages and endothelial cells. IL-6 acts upon a variety of cells including myeloid progenitor cells, T cells, B cells, and hepatocytes. In addition, IL-6 appears to interact with IL-2 in the proliferation of T lymphocytes. IL-6 potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors. IL-6 plays a critical role in B-cell differentiation to plasma cells and is a potent growth factor for plasmacytoma and myeloma. IL-6 is a very useful culture supplement for the generation of a high number of antibody-producing hybridomas. Primarily produced at sites of acute and chronic inflammation, IL-6 is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of IL-6 is implicated in a wide variety of inflammation-associated disease states including diabetes mellitus and systemic juvenile rheumatoid arthritis.

Immunogen :

Purified recombinant rat IL-6.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay-dependent, Western Blot: Assay-dependent

Aliases :

B-cell differentiation factor; B-cell hybridoma growth factor; B-cell stimulatory factor 2; BSF2; BSF-2; CDF; CHIL-6; CTL differentiation factor; cytokine; HGF; H-IL-6; HSF; hybridoma growth factor; Ifnb2; IFN-beta-2; Il6; IL-6; ILg6; ILN; interferon beta-2; Interleukin; interleukin 6; Interleukin 6 (interferon, beta 2); interleukin 6 precursor; interleukin BSF-2; interleukin HP-1; Interleukin6; Interleukin-6; interleukin-6 precursor; interleukin-6 protein; M-IL-6; prointerleukin 6; R-IL-6

more info or order :

Invitrogen product webpage