CD3e Monoclonal Antibody (FN-18), FITC | Invitrogen APS0308 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD3e Monoclonal Antibody (FN-18), FITC

catalog :

APS0308

quantity :

50 ug

price :

US 474.00

clonality :

monoclonal

host :

mouse

conjugate :

FITC

clone name :

FN-18

reactivity :

African green monkey, crab eating macaque, sooty mangabey, human, rhesus macaque

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 26

Published Application/Species/Sample/Dilution	Reference
flow cytometry; crab eating macaque	Titti F, Maggiorella M, Ferrantelli F, Sernicola L, Bellino S, Collacchi B, et al. Biocompatible anionic polymeric microspheres as priming delivery system for effetive HIV/AIDS Tat-based vaccines. PLoS ONE. 2014;9:e111360 pubmed publisher
flow cytometry; rhesus macaque	Inaba K, Fukazawa Y, Matsuda K, Himeno A, Matsuyama M, Ibuki K, et al. Small intestine CD4+ cell reduction and enteropathy in simian/human immunodeficiency virus KS661-infected rhesus macaques in the presence of low viral load. J Gen Virol. 2010;91:773-81 pubmed publisher
flow cytometry; human; fig 6	Stolte Leeb N, Bieler K, Kostler J, Heeney J, Haaft P, Suh Y, et al. Better protective effects in rhesus macaques by combining systemic and mucosal application of a dual component vector vaccine after rectal SHIV89.6P challenge compared to systemic vaccination alone. Viral Immunol. 2008;21:235-46 pubmed publisher
flow cytometry; African green monkey; fig 4	Nagata N, Iwata N, Hasegawa H, Sato Y, Morikawa S, Saijo M, et al. Pathology and virus dispersion in cynomolgus monkeys experimentally infected with severe acute respiratory syndrome coronavirus via different inoculation routes. Int J Exp Pathol. 2007;88:403-14 pubmed
flow cytometry; rhesus macaque; loading ...; fig 2c	Lai L, Vödrös D, Kozlowski P, Montefiori D, Wilson R, Akerstrom V, et al. GM-CSF DNA: an adjuvant for higher avidity IgG, rectal IgA, and increased protection against the acute phase of a SHIV-89.6P challenge by a DNA/MVA immunodeficiency virus vaccine. Virology. 2007;369:153-67 pubmed
flow cytometry; African green monkey	Maggiorella M, Sernicola L, Crostarosa F, Belli R, Pavone Cossut M, Macchia I, et al. Multiprotein genetic vaccine in the SIV-Macaca animal model: a promising approach to generate sterilizing immunity to HIV infection. J Med Primatol. 2007;36:180-94 pubmed
flow cytometry; rhesus macaque	Kuwata T, Kodama M, Sato A, Suzuki H, Miyazaki Y, Miura T, et al. Contribution of monocytes to viral replication in macaques during acute infection with simian immunodeficiency virus. AIDS Res Hum Retroviruses. 2007;23:372-80 pubmed
flow cytometry; rhesus macaque	Motohara M, Ibuki K, Miyake A, Fukazawa Y, Inaba K, Suzuki H, et al. Impaired T-cell differentiation in the thymus at the early stages of acute pathogenic chimeric simian-human immunodeficiency virus (SHIV) infection in contrast to less pathogenic SHIV infection. Microbes Infect. 2006;8:1539-49 pubmed
flow cytometry; rhesus macaque; fig 7	Miyake A, Ibuki K, Enose Y, Suzuki H, Horiuchi R, Motohara M, et al. Rapid dissemination of a pathogenic simian/human immunodeficiency virus to systemic organs and active replication in lymphoid tissues following intrarectal infection. J Gen Virol. 2006;87:1311-20 pubmed
flow cytometry; rhesus macaque	Kaneyasu K, Kita M, Ohkura S, Yamamoto T, Ibuki K, Enose Y, et al. Protective efficacy of nonpathogenic nef-deleted SHIV vaccination combined with recombinant IFN-gamma administration against a pathogenic SHIV challenge in rhesus monkeys. Microbiol Immunol. 2005;49:1083-94 pubmed
flow cytometry; rhesus macaque; fig 3	Hsu M, Ho S, Balfe P, Gettie A, Harouse J, Blanchard J, et al. A CCR5-tropic simian-HIV molecular clone capable of inducing AIDS in rhesus macaques. J Acquir Immune Defic Syndr. 2005;40:383-7 pubmed
flow cytometry; African green monkey; fig 2	Chege G, Williamson A, Passmore J, Bourn W, Ryffel B, Shephard E. The immune response of the Chacma baboon to Bacille Calmette Guerin: development of a primate model for BCG-based vaccine research. Vaccine. 2005;23:5783-91 pubmed
flow cytometry; rhesus macaque	Boadi T, Schneider E, Chung S, Tsai L, Gettie A, Ratterree M, et al. Cellulose acetate 1,2-benzenedicarboxylate protects against challenge with pathogenic X4 and R5 simian/human immunodeficiency virus. AIDS. 2005;19:1587-94 pubmed
flow cytometry; rhesus macaque; fig 5	Miyake A, Ibuki K, Suzuki H, Horiuchi R, Saito N, Motohara M, et al. Early virological events in various tissues of newborn monkeys after intrarectal infection with pathogenic simian human immunodeficiency virus. J Med Primatol. 2005;34:294-302 pubmed
flow cytometry; rhesus macaque	Sadagopal S, Amara R, Montefiori D, Wyatt L, Staprans S, Kozyr N, et al. Signature for long-term vaccine-mediated control of a Simian and human immunodeficiency virus 89.6P challenge: stable low-breadth and low-frequency T-cell response capable of coproducing gamma interferon and interleukin-2. J Virol. 2005;79:3243-53 pubmed
flow cytometry; rhesus macaque	Enose Y, Kita M, Yamamoto T, Suzuki H, Miyake A, Horiuchi R, et al. Protective effects of nef-deleted SHIV or that having IFN-gamma against disease induced with a pathogenic virus early after vaccination. Arch Virol. 2004;149:1705-20 pubmed
flow cytometry; rhesus macaque	Khatissian E, Monceaux V, Cumont M, Ho Tsong Fang R, Estaquier J, Hurtrel B. Simian immunodeficiency virus infection of CD4+CD8+ T cells in a macaque with an unusually high peripheral CD4+CD8+ T lymphocyte count. AIDS Res Hum Retroviruses. 2003;19:267-74 pubmed
flow cytometry; African green monkey	Buckner C, Gettie A, Tan R, Eshetu T, Ratterree M, Blanchard J, et al. Infection of macaques with a molecular clone, SHIVSF33A2, provides evidence for tissue specific variants. J Med Primatol. 2002;31:164-70 pubmed
flow cytometry; rhesus macaque	Amara R, Villinger F, Altman J, Lydy S, O Neil S, Staprans S, et al. Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine. Vaccine. 2002;20:1949-55 pubmed
flow cytometry; rhesus macaque	Uda A, Tanabayashi K, Mukai R, Yachi M, Nam K, Yamada A. CD3 polymorphism in cynomolgus monkeys (Macaca fascicularis). J Med Primatol. 2001;30:141-7 pubmed
flow cytometry; crab eating macaque	Quesniaux V, Menninger K, Kunkler A, Vedrine C, Bernhard M, Hedinger R, et al. The novel immunosuppressant FTY720 induces peripheral lymphodepletion of both T- and B-cells in cynomolgus monkeys when given alone, with Cyclosporine Neoral or with RAD. Transpl Immunol. 2000;8:177-87 pubmed
flow cytometry; human	Lafont B, Gloeckler L, D Hautcourt J, Gut J, Aubertin A. One-round determination of seven leukocyte subsets in rhesus macaque blood by flow cytometry. Cytometry. 2000;41:193-202 pubmed
flow cytometry; rhesus macaque	Dykhuizen M, Ceman J, Mitchen J, Zayas M, MacDougall A, Helgeland J, et al. Importance of the CD3 marker for evaluating changes in rhesus macaque CD4/CD8 T-cell ratios. Cytometry. 2000;40:69-75 pubmed
flow cytometry; rhesus macaque	Giavedoni L, Velasquillo M, Parodi L, Hubbard G, Hodara V. Cytokine expression, natural killer cell activation, and phenotypic changes in lymphoid cells from rhesus macaques during acute infection with pathogenic simian immunodeficiency virus. J Virol. 2000;74:1648-57 pubmed
flow cytometry; sooty mangabey flow cytometry; rhesus macaque	Chakrabarti L, Lewin S, Zhang L, Gettie A, Luckay A, Martin L, et al. Normal T-cell turnover in sooty mangabeys harboring active simian immunodeficiency virus infection. J Virol. 2000;74:1209-23 pubmed
flow cytometry; rhesus macaque; fig 4	Villinger F, Brice G, Mayne A, Bostik P, Ansari A. Control mechanisms of virus replication in naturally SIVsmm infected mangabeys and experimentally infected macaques. Immunol Lett. 1999;66:37-46 pubmed

product information

Product Type :

Antibody

Product Name :

CD3e Monoclonal Antibody (FN-18), FITC

Catalog # :

APS0308

Quantity :

50 ug

Price :

US 474.00

Clonality :

Monoclonal

Purity :

Ion-exchange chromatography

Host :

Mouse

Reactivity :

Non-human primate, Rhesus Monkey

Applications :

Flow Cytometry: Assay-dependent

Species :

Non-human primate, Rhesus Monkey

Clone :

FN-18

Isotype :

IgG1

Storage :

4 C, store in dark

Description :

The CD3 subunit complex which is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules and this association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. The genes encoding the CD3 epsilon, gamma and delta polypeptides are located on chromosome 11. Defects in the CD3 gene are associated with CD3 immunodeficiency.

Immunogen :

Rhesus monkey peripheral blood mononuclear cells

Format :

Lyophilized

Applications w/Dilutions :

Flow Cytometry: Assay-dependent

Aliases :

4930549J05Rik; A430104F18Rik; AI504783; antigen CD3D, delta polypeptide (TiT3 complex); antigen CD3E, epsilon polypeptide (TiT3 complex); antigen CD3G, gamma polypeptide; antigen CD3Z, zeta polypeptide; AW552088; Cd247; CD247 antigen; CD247 antigen, zeta subunit; Cd247 molecule; CD3; CD3 antigen delta chain; CD3 antigen delta polypeptide; CD3 antigen gamma chain; CD3 antigen, delta polypeptide; CD3 antigen, delta subunit; CD3 antigen, epsilon polypeptide; CD3 antigen, gamma polypeptide; CD3 antigen, zeta polypeptide; CD3 delta; CD3 epsilon; CD3 epsilon chain; CD3 epsilon subunit; CD3 epsilon subunit precursor; CD3 gamma-chain; CD3 glycoprotein; CD3 glycoprotein precursor; CD3 molecule delta polypeptide; CD3 molecule, delta; CD3 molecule, epsilon; CD3 molecule, epsilon polypeptide; CD3 molecule, gamma; CD3 molecule, gamma polypeptide; CD3 protein; CD3 TCR complex; CD3 type I transmembrane glycoprotein; CD3 type I transmembrane glycoprotein precursor; CD3 zeta chain; Cd3d; CD3D antigen delta; CD3D antigen, delta polypeptide (TiT3 complex); CD3d molecule; CD3d molecule, delta (CD3-TCR complex); CD3-DELTA; Cd3e; CD3E antigen, epsilon polypeptide; CD3E antigen, epsilon polypeptide (TiT3 complex); CD3e molecule; CD3e molecule, epsilon (CD3-TCR complex); CD3epsilon; CD3-epsilon; Cd3-eta; Cd3g; CD3G antigen, gamma polypeptide; CD3g antigen, gamma polypeptide (TiT3 complex); CD3g molecule; CD3g molecule, epsilon (CD3-TCR complex); CD3g molecule, gamma (CD3-TCR complex); CD3-GAMMA; Cd3h; CD3Q; Cd3z; CD3Z antigen, zeta polypeptide (TiT3 complex); Cd3zeta; Cd3-zeta; CD3zeta chain; CD3-zeta/eta; Ctg3; Ctg-3; FLJ18683; IMD17; IMD18; IMD19; IMD25; Leu-4; OKT3, delta chain; T cell antigen receptor complex epsilon subunit of T3; T3/TCR complex; T3d; T3e; T3g; T3Z; T-cell antigen receptor complex, epsilon subunit of T3; T-cell antigen receptor complex, gamma subunit of T3; T-cell antigen receptor complex, zeta subunit of CD3; T-cell receptor CD3 epsilon chain; T-cell receptor CD3 epsilon subunit; T-cell receptor CD3 subunit zeta; T-cell receptor CD3, subunit zeta; T-cell receptor T3 delta chain; T-cell receptor T3 eta chain; T-cell receptor T3 gamma chain; T-cell receptor T3 zeta chain; T-cell receptor zeta chain; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 delta chain; T-cell surface glycoprotein CD3 epsilon chain; T-cell surface glycoprotein CD3 gamma chain; T-cell surface glycoprotein CD3 zeta chain; T-cell surface protein; TcR CD3 delta-chain; TcR CD3 gamma-chain; TCR zeta chain; TCR zeta chain subunit; TCRE; Tcrk; TCRZ; TCRzeta; TiT3 complex; type I transmembrane protein; T-cell surface molecule CD3

more info or order :

Invitrogen product webpage