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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD3e Monoclonal Antibody (FN-18)
catalog :
APS0301
quantity :
500 µg
price :
US 786.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
FN-18
reactivity :
crab eating macaque, African green monkey, human, rhesus macaque
application :
ELISA, immunocytochemistry, flow cytometry, immunohistochemistry - frozen section, blocking or activating experiments
more info or order :
citations: 50
| Published Application/Species/Sample/Dilution | Reference |
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| Bostik P, Kobkitjaroen J, Tang W, Villinger F, Pereira L, Little D, et al. Decreased NK cell frequency and function is associated with increased risk of KIR3DL allele polymorphism in simian immunodeficiency virus-infected rhesus macaques with high viral loads. J Immunol. 2009;182:3638-49 pubmed publisher
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| Stolte Leeb N, Bieler K, Kostler J, Heeney J, Haaft P, Suh Y, et al. Better protective effects in rhesus macaques by combining systemic and mucosal application of a dual component vector vaccine after rectal SHIV89.6P challenge compared to systemic vaccination alone. Viral Immunol. 2008;21:235-46 pubmed publisher
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| Nagata N, Iwata N, Hasegawa H, Sato Y, Morikawa S, Saijo M, et al. Pathology and virus dispersion in cynomolgus monkeys experimentally infected with severe acute respiratory syndrome coronavirus via different inoculation routes. Int J Exp Pathol. 2007;88:403-14 pubmed
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| Pereira L, Villinger F, Wulff H, Sankaranarayanan A, Raman G, Ansari A. Pharmacokinetics, toxicity, and functional studies of the selective Kv1.3 channel blocker 5-(4-phenoxybutoxy)psoralen in rhesus macaques. Exp Biol Med (Maywood). 2007;232:1338-54 pubmed
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| Lai L, Vödrös D, Kozlowski P, Montefiori D, Wilson R, Akerstrom V, et al. GM-CSF DNA: an adjuvant for higher avidity IgG, rectal IgA, and increased protection against the acute phase of a SHIV-89.6P challenge by a DNA/MVA immunodeficiency virus vaccine. Virology. 2007;369:153-67 pubmed
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| Onlamoon N, Plagman N, Rogers K, Mayne A, Bostik P, Pattanapanyasat K, et al. Anti-CD3/28 mediated expansion of macaque CD4+ T cells is polyclonal and provides extended survival after adoptive transfer. J Med Primatol. 2007;36:206-18 pubmed
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| Maggiorella M, Sernicola L, Crostarosa F, Belli R, Pavone Cossut M, Macchia I, et al. Multiprotein genetic vaccine in the SIV-Macaca animal model: a promising approach to generate sterilizing immunity to HIV infection. J Med Primatol. 2007;36:180-94 pubmed
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| Kuwata T, Kodama M, Sato A, Suzuki H, Miyazaki Y, Miura T, et al. Contribution of monocytes to viral replication in macaques during acute infection with simian immunodeficiency virus. AIDS Res Hum Retroviruses. 2007;23:372-80 pubmed
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| Marcondes M, Penedo M, Lanigan C, Hall D, Watry D, Zandonatti M, et al. Simian immunodeficiency virus-induced CD4+ T cell deficits in cytokine secretion profile are dependent on monkey origin. Viral Immunol. 2006;19:679-89 pubmed
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| Onlamoon N, Hudson K, Bryan P, Mayne A, Bonyhadi M, Berenson R, et al. Optimization of in vitro expansion of macaque CD4 T cells using anti-CD3 and co-stimulation for autotransfusion therapy. J Med Primatol. 2006;35:178-93 pubmed
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| Motohara M, Ibuki K, Miyake A, Fukazawa Y, Inaba K, Suzuki H, et al. Impaired T-cell differentiation in the thymus at the early stages of acute pathogenic chimeric simian-human immunodeficiency virus (SHIV) infection in contrast to less pathogenic SHIV infection. Microbes Infect. 2006;8:1539-49 pubmed
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| Miyake A, Ibuki K, Enose Y, Suzuki H, Horiuchi R, Motohara M, et al. Rapid dissemination of a pathogenic simian/human immunodeficiency virus to systemic organs and active replication in lymphoid tissues following intrarectal infection. J Gen Virol. 2006;87:1311-20 pubmed
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| Bostik P, Noble E, Mayne A, Gargano L, Villinger F, Ansari A. Central memory CD4 T cells are the predominant cell subset resistant to anergy in SIV disease resistant sooty mangabeys. AIDS. 2006;20:181-8 pubmed
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| Kaneyasu K, Kita M, Ohkura S, Yamamoto T, Ibuki K, Enose Y, et al. Protective efficacy of nonpathogenic nef-deleted SHIV vaccination combined with recombinant IFN-gamma administration against a pathogenic SHIV challenge in rhesus monkeys. Microbiol Immunol. 2005;49:1083-94 pubmed
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| Mortara L, Ploquin M, Faye A, Scott Algara D, Vaslin B, BUTOR C, et al. Phenotype and function of myeloid dendritic cells derived from African green monkey blood monocytes. J Immunol Methods. 2006;308:138-55 pubmed
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| Hsu M, Ho S, Balfe P, Gettie A, Harouse J, Blanchard J, et al. A CCR5-tropic simian-HIV molecular clone capable of inducing AIDS in rhesus macaques. J Acquir Immune Defic Syndr. 2005;40:383-7 pubmed
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| Boadi T, Schneider E, Chung S, Tsai L, Gettie A, Ratterree M, et al. Cellulose acetate 1,2-benzenedicarboxylate protects against challenge with pathogenic X4 and R5 simian/human immunodeficiency virus. AIDS. 2005;19:1587-94 pubmed
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| Miyake A, Ibuki K, Suzuki H, Horiuchi R, Saito N, Motohara M, et al. Early virological events in various tissues of newborn monkeys after intrarectal infection with pathogenic simian human immunodeficiency virus. J Med Primatol. 2005;34:294-302 pubmed
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| Horiuchi R, Akahata W, Kuwata T, Enose Y, Ido E, Suzuki H, et al. DNA vaccination of macaques by a full-genome SHIV plasmid that has an IL-2 gene and produces non-infectious virus particles. Vaccine. 2006;24:3677-85 pubmed
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| Suzuki H, Motohara M, Miyake A, Ibuki K, Fukazawa Y, Inaba K, et al. Intrathymic effect of acute pathogenic SHIV infection on T-lineage cells in newborn macaques. Microbiol Immunol. 2005;49:667-79 pubmed
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| Casetti R, Perretta G, Taglioni A, Mattei M, Colizzi V, Dieli F, et al. Drug-induced expansion and differentiation of V gamma 9V delta 2 T cells in vivo: the role of exogenous IL-2. J Immunol. 2005;175:1593-8 pubmed
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| Lazarevic V, Pawar S, Flynn J. Measuring T-cell function in animal models of tuberculosis by ELISPOT. Methods Mol Biol. 2005;302:179-90 pubmed
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| Hodara V, Velasquillo M, Parodi L, Giavedoni L. Expression of CD154 by a simian immunodeficiency virus vector induces only transitory changes in rhesus macaques. J Virol. 2005;79:4679-90 pubmed
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| Contamin H, Loizon S, Bourreau E, Michel J, Garraud O, Mercereau Puijalon O, et al. Flow cytometry identification and characterization of mononuclear cell subsets in the neotropical primate Saimiri sciureus (squirrel monkey). J Immunol Methods. 2005;297:61-71 pubmed
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| Sadagopal S, Amara R, Montefiori D, Wyatt L, Staprans S, Kozyr N, et al. Signature for long-term vaccine-mediated control of a Simian and human immunodeficiency virus 89.6P challenge: stable low-breadth and low-frequency T-cell response capable of coproducing gamma interferon and interleukin-2. J Virol. 2005;79:3243-53 pubmed
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| Enose Y, Kita M, Yamamoto T, Suzuki H, Miyake A, Horiuchi R, et al. Protective effects of nef-deleted SHIV or that having IFN-gamma against disease induced with a pathogenic virus early after vaccination. Arch Virol. 2004;149:1705-20 pubmed
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| Benlhassan Chahour K, Penit C, Dioszeghy V, Vasseur F, Janvier G, Riviere Y, et al. Kinetics of lymphocyte proliferation during primary immune response in macaques infected with pathogenic simian immunodeficiency virus SIVmac251: preliminary report of the effect of early antiviral therapy. J Virol. 2003;77:12479-93 pubmed
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| Khatissian E, Monceaux V, Cumont M, Ho Tsong Fang R, Estaquier J, Hurtrel B. Simian immunodeficiency virus infection of CD4+CD8+ T cells in a macaque with an unusually high peripheral CD4+CD8+ T lymphocyte count. AIDS Res Hum Retroviruses. 2003;19:267-74 pubmed
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| Casimiro D, Chen L, Fu T, Evans R, Caulfield M, Davies M, et al. Comparative immunogenicity in rhesus monkeys of DNA plasmid, recombinant vaccinia virus, and replication-defective adenovirus vectors expressing a human immunodeficiency virus type 1 gag gene. J Virol. 2003;77:6305-13 pubmed
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| Sugimoto C, Tadakuma K, Otani I, Moritoyo T, Akari H, Ono F, et al. nef gene is required for robust productive infection by simian immunodeficiency virus of T-cell-rich paracortex in lymph nodes. J Virol. 2003;77:4169-80 pubmed
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| Villinger F, Mayne A, Bostik P, Mori K, Jensen P, Ahmed R, et al. Evidence for antibody-mediated enhancement of simian immunodeficiency virus (SIV) Gag antigen processing and cross presentation in SIV-infected rhesus macaques. J Virol. 2003;77:10-24 pubmed
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| Buckner C, Gettie A, Tan R, Eshetu T, Ratterree M, Blanchard J, et al. Infection of macaques with a molecular clone, SHIVSF33A2, provides evidence for tissue specific variants. J Med Primatol. 2002;31:164-70 pubmed
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| Amara R, Villinger F, Staprans S, Altman J, Montefiori D, Kozyr N, et al. Different patterns of immune responses but similar control of a simian-human immunodeficiency virus 89.6P mucosal challenge by modified vaccinia virus Ankara (MVA) and DNA/MVA vaccines. J Virol. 2002;76:7625-31 pubmed
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| Amara R, Smith J, Staprans S, Montefiori D, Villinger F, Altman J, et al. Critical role for Env as well as Gag-Pol in control of a simian-human immunodeficiency virus 89.6P challenge by a DNA prime/recombinant modified vaccinia virus Ankara vaccine. J Virol. 2002;76:6138-46 pubmed
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| Croix D, Board K, Capuano S, Murphey Corb M, Haidaris C, Flynn J, et al. Alterations in T lymphocyte profiles of bronchoalveolar lavage fluid from SIV- and Pneumocystis carinii-coinfected rhesus macaques. AIDS Res Hum Retroviruses. 2002;18:391-401 pubmed
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| De Maria A, Biassoni R, Fogli M, Rizzi M, Cantoni C, Costa P, et al. Identification, molecular cloning and functional characterization of NKp46 and NKp30 natural cytotoxicity receptors in Macaca fascicularis NK cells. Eur J Immunol. 2001;31:3546-56 pubmed
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| Zhou P, Lee J, Moore P, Brasky K. High-efficiency gene transfer into rhesus macaque primary T lymphocytes by combining 32 degrees C centrifugation and CH-296-coated plates: effect of gene transfer protocol on T cell homing receptor expression. Hum Gene Ther. 2001;12:1843-55 pubmed
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| Pichyangkul S, Saengkrai P, Yongvanitchit K, Limsomwong C, Gettayacamin M, Walsh D, et al. Isolation and characterization of rhesus blood dendritic cells using flow cytometry. J Immunol Methods. 2001;252:15-23 pubmed
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| Giavedoni L, Imhoof J, Velasquillo M, Parodi L, Hodara V. Expression of the interleukin-18 gene from rhesus macaque by the simian immunodeficiency virus does not result in increased viral replication. J Interferon Cytokine Res. 2001;21:173-80 pubmed
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| Keller E, Zhang J, Yao Z, Qi Y. The impact of chronic estrogen deprivation on immunologic parameters in the ovariectomized rhesus monkey (Macaca mulatta) model of menopause. J Reprod Immunol. 2001;50:41-55 pubmed
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| Croix D, Capuano S, Simpson L, Fallert B, Fuller C, Klein E, et al. Effect of mycobacterial infection on virus loads and disease progression in simian immunodeficiency virus-infected rhesus monkeys. AIDS Res Hum Retroviruses. 2000;16:1895-908 pubmed
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| Cafaro A, Caputo A, Maggiorella M, Baroncelli S, Fracasso C, Pace M, et al. SHIV89.6P pathogenicity in cynomolgus monkeys and control of viral replication and disease onset by human immunodeficiency virus type 1 Tat vaccine. J Med Primatol. 2000;29:193-208 pubmed
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product information
Product Type :
Antibody
Product Name :
CD3e Monoclonal Antibody (FN-18)
Catalog # :
APS0301
Quantity :
500 µg
Price :
US 786.00
Clonality :
Monoclonal
Purity :
Ion-exchange chromatography
Host :
Mouse
Reactivity :
Non-human primate, Rhesus Monkey
Applications :
Flow Cytometry: Assay-dependent
Species :
Non-human primate, Rhesus Monkey
Clone :
FN-18
Isotype :
IgG1
Storage :
4° C
Description :
The CD3 subunit complex which is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules and this association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. The genes encoding the CD3 epsilon, gamma and delta polypeptides are located on chromosome 11. Defects in the CD3 gene are associated with CD3 immunodeficiency.
Immunogen :
Rhesus monkey peripheral blood leukocytes.
Format :
Lyophilized
Applications w/Dilutions :
Flow Cytometry: Assay-dependent
Aliases :
4930549J05Rik; A430104F18Rik; AI504783; antigen CD3D, delta polypeptide (TiT3 complex); antigen CD3E, epsilon polypeptide (TiT3 complex); antigen CD3G, gamma polypeptide; antigen CD3Z, zeta polypeptide; AW552088; Cd247; CD247 antigen; CD247 antigen, zeta subunit; Cd247 molecule; CD3; CD3 antigen delta chain; CD3 antigen delta polypeptide; CD3 antigen gamma chain; CD3 antigen, delta polypeptide; CD3 antigen, delta subunit; CD3 antigen, epsilon polypeptide; CD3 antigen, gamma polypeptide; CD3 antigen, zeta polypeptide; CD3 delta; CD3 epsilon; CD3 epsilon chain; CD3 epsilon subunit; CD3 epsilon subunit precursor; CD3 gamma-chain; CD3 glycoprotein; CD3 glycoprotein precursor; CD3 molecule delta polypeptide; CD3 molecule, delta; CD3 molecule, epsilon; CD3 molecule, epsilon polypeptide; CD3 molecule, gamma; CD3 molecule, gamma polypeptide; CD3 protein; CD3 type I transmembrane glycoprotein; CD3 type I transmembrane glycoprotein precursor; CD3 zeta chain; Cd3d; CD3D antigen delta; CD3D antigen, delta polypeptide (TiT3 complex); CD3d molecule; CD3d molecule, delta (CD3-TCR complex); CD3-DELTA; Cd3e; CD3E antigen, epsilon polypeptide; CD3E antigen, epsilon polypeptide (TiT3 complex); CD3e molecule; CD3e molecule, epsilon (CD3-TCR complex); CD3epsilon; CD3-epsilon; Cd3-eta; Cd3g; CD3G antigen, gamma polypeptide; CD3g antigen, gamma polypeptide (TiT3 complex); CD3g molecule; CD3g molecule, epsilon (CD3-TCR complex); CD3g molecule, gamma (CD3-TCR complex); CD3-GAMMA; Cd3h; CD3Q; Cd3z; CD3Z antigen, zeta polypeptide (TiT3 complex); Cd3zeta; Cd3-zeta; CD3zeta chain; CD3-zeta/eta; Ctg3; Ctg-3; FLJ18683; IMD17; IMD18; IMD19; IMD25; Leu-4; OKT3, delta chain; T3/TCR complex; T3d; T3e; T3g; T3Z; T-cell antigen receptor complex, epsilon subunit of T3; T-cell antigen receptor complex, gamma subunit of T3; T-cell antigen receptor complex, zeta subunit of CD3; T-cell receptor CD3 epsilon chain; T-cell receptor CD3 epsilon subunit; T-cell receptor CD3 subunit zeta; T-cell receptor CD3, subunit zeta; T-cell receptor T3 delta chain; T-cell receptor T3 eta chain; T-cell receptor T3 gamma chain; T-cell receptor T3 zeta chain; T-cell receptor zeta chain; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 delta chain; T-cell surface glycoprotein CD3 epsilon chain; T-cell surface glycoprotein CD3 gamma chain; T-cell surface glycoprotein CD3 zeta chain; T-cell surface protein; TcR CD3 delta-chain; TcR CD3 gamma-chain; TCR zeta chain; TCR zeta chain subunit; TCRE; Tcrk; TCRZ; TCRzeta; TiT3 complex; type I transmembrane protein; T-cell surface molecule CD3
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com81 Wyman Street
Waltham, MA USA 02451
800-678-5599
headquarters: USA
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