TNF alpha Monoclonal Antibody (MP6-XT3) | Invitrogen AMC3812 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TNF alpha Monoclonal Antibody (MP6-XT3)

catalog :

AMC3812

quantity :

500 µg

price :

US 399.00

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

MP6-XT3

reactivity :

mouse

application :

neutralization, blocking or activating experiments

more info or order :

Invitrogen product webpage

citations: 5

Published Application/Species/Sample/Dilution	Reference
blocking or activating experiments; mouse	Ribeiro Gomes F, Otero A, Gomes N, Moniz de Souza M, Cysne Finkelstein L, Arnholdt A, et al. Macrophage interactions with neutrophils regulate Leishmania major infection. J Immunol. 2004;172:4454-62 pubmed
	Finsterwalder R, Ganesan M, Leb H, Habertheuer A, Basílio J, Lang I, et al. Hypoxia/reperfusion predisposes to atherosclerosis. PLoS ONE. 2018;13:e0205067 pubmed publisher
	Sheng L, Jena P, Hu Y, Liu H, Nagar N, Kalanetra K, et al. Hepatic inflammation caused by dysregulated bile acid synthesis is reversible by butyrate supplementation. J Pathol. 2017;243:431-441 pubmed publisher
	Linz B, Neely C, Kartchner L, Mendoza A, Khoury A, Truax A, et al. Innate Immune Cell Recovery Is Positively Regulated by NLRP12 during Emergency Hematopoiesis. J Immunol. 2017;198:2426-2433 pubmed publisher
	Chen H, Hofman F, Kung J, Lin Y, Wu Hsieh B. Both virus and tumor necrosis factor alpha are critical for endothelium damage in a mouse model of dengue virus-induced hemorrhage. J Virol. 2007;81:5518-26 pubmed

product information

Product Type :

Antibody

Product Name :

TNF alpha Monoclonal Antibody (MP6-XT3)

Catalog # :

AMC3812

Quantity :

500 µg

Price :

US 399.00

Clonality :

Monoclonal

Purity :

purified

Host :

Rat

Reactivity :

Mouse

Applications :

Functional assay: Assay-dependent, Neutralization: Assay-dependent

Species :

Mouse

Clone :

MP6-XT3

Isotype :

IgG1, kappa

Storage :

-20°C

Description :

TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophage and bind to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions. Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis when injected into tumor-bearing mice. Other functions of TNF-alpha include its role in the immune response to bacterial, viral, parasitic and certain fungal infections, as well as its role in the necrosis of specific tumors. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.

Immunogen :

Recombinant TNF-alpha

Format :

Liquid

Applications w/Dilutions :

Functional assay: Assay-dependent, Neutralization: Assay-dependent

Aliases :

APC1 protein; Cachectin; C-domain 1; C-domain 2; cTNF; DADB-70P7.1; DIF; ICD1; ICD2; Intracellular domain 1; Intracellular domain 2; N-terminal fragment; NTF; RATTNF; Tnf; TNF alpha; TNF superfamily; TNF a; TNF, macrophage-derived; TNF, monocyte-derived; TNFA; TNF-a; TNFalpha; TNF-alpha; Tnfsf1a; TNFSF2; TNFa; TNLG1F; Tumor necrosis factor; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; tumor necrosis factor alpha (cachetin); tumor necrosis factor alpha precursor; tumor necrosis factor ligand 1F; tumor necrosis factor ligand superfamily member 2; Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form; tumor necrosis factor-alpha; tumor necrosis factor-alpha precursor; tumor-necrosis factor; tumour necrosis factor

more info or order :

Invitrogen product webpage