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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
TNF alpha Monoclonal Antibody (TN3), Biotin
catalog :
AMC3719
quantity :
100 uL
price :
US 414.00
clonality :
monoclonal
host :
hamsters
conjugate :
biotin
clone name :
TN3
reactivity :
mouse, domestic rabbit
application :
western blot, ELISA
more info or order :
Invitrogen product webpage
citations: 1
Published Application/Species/Sample/DilutionReference
  • ELISA; domestic rabbit; loading ...; fig 1
Diaz Llopis M, Garcia Delpech S, Salom D, Udaondo P, Bosch Morell F, Quijada A, et al. High-dose infliximab prophylaxis in endotoxin-induced uveitis. J Ocul Pharmacol Ther. 2007;23:343-50 pubmed
product information
Product Type :
Antibody
Product Name :
TNF alpha Monoclonal Antibody (TN3), Biotin
Catalog # :
AMC3719
Quantity :
100 uL
Price :
US 414.00
Clonality :
Monoclonal
Purity :
purified
Host :
Armenian Hamster
Reactivity :
Mouse
Applications :
ELISA: Assay-dependent, Western Blot: Assay-dependent
Species :
Mouse
Clone :
TN3
Isotype :
IgG
Storage :
-20 C
Description :
TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophage and bind to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions. Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis when injected into tumor-bearing mice. Other functions of TNF-alpha include its role in the immune response to bacterial, viral, parasitic and certain fungal infections, as well as its role in the necrosis of specific tumors. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.
Immunogen :
Recombinant mouse tumor necrosis factor-alpha (TNF-alpha)
Format :
Liquid
Applications w/Dilutions :
ELISA: Assay-dependent, Western Blot: Assay-dependent
Aliases :
APC1 protein; Cachectin; C-domain 1; C-domain 2; cTNF; DADB-70P7.1; DIF; ICD1; ICD2; Intracellular domain 1; Intracellular domain 2; N-terminal fragment; NTF; RATTNF; Tnf; TNF alpha; TNF superfamily; TNF a; TNF, macrophage-derived; TNF, monocyte-derived; TNFA; TNF-a; TNFalpha; TNF-alpha; Tnfsf1a; TNFSF2; TNFa; TNLG1F; Tumor necrosis factor; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; tumor necrosis factor alpha (cachetin); tumor necrosis factor alpha precursor; tumor necrosis factor ligand 1F; tumor necrosis factor ligand superfamily member 2; Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form; tumor necrosis factor-alpha; tumor necrosis factor-alpha precursor; tumor-necrosis factor; tumour necrosis factor
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA