IL-6 Monoclonal Antibody (MP5 20F3) | Invitrogen AMC0862 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IL-6 Monoclonal Antibody (MP5 20F3)

catalog :

AMC0862

quantity :

500 µg

price :

US 375.00

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

MP5 20F3

reactivity :

mouse

application :

western blot, ELISA, immunohistochemistry, neutralization, flow cytometry, blocking or activating experiments, other

more info or order :

Invitrogen product webpage

citations: 15

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; loading ...; fig 4	Kim K, Lee J, Ahn S, Won R, Kim S, Jeong S, et al. The methanol extract of Guettarda speciosa Linn. Ameliorates acute lung injury in mice. BMC Complement Med Ther. 2020;20:40 pubmed publisher
ELISA; mouse; fig 5a	Raynor J, Karns R, Almanan M, Li K, Divanovic S, Chougnet C, et al. IL-6 and ICOS Antagonize Bim and Promote Regulatory T Cell Accrual with Age. J Immunol. 2015;195:944-52 pubmed publisher
other; mouse; fig 6 blocking or activating experiments; mouse; fig 4	Tracz M, Juncos J, Croatt A, Ackerman A, Grande J, Knutson K, et al. Deficiency of heme oxygenase-1 impairs renal hemodynamics and exaggerates systemic inflammatory responses to renal ischemia. Kidney Int. 2007;72:1073-80 pubmed
blocking or activating experiments; mouse; 1.25 ug/ml	Martín Orozco E, Kobayashi H, Van Uden J, Nguyen M, Kornbluth R, Raz E. Enhancement of antigen-presenting cell surface molecules involved in cognate interactions by immunostimulatory DNA sequences. Int Immunol. 1999;11:1111-8 pubmed
	Mielke L, Liao Y, Clemens E, Firth M, Duckworth B, Huang Q, et al. TCF-1 limits the formation of Tc17 cells via repression of the MAF-RORγt axis. J Exp Med. 2019;: pubmed publisher
	Zhou L, Chu C, Teng F, Bessman N, Goc J, Santosa E, et al. Innate lymphoid cells support regulatory T cells in the intestine through interleukin-2. Nature. 2019;568:405-409 pubmed publisher
	Mora Cartín R, Gutiérrez Jiménez C, Alfaro Alarcón A, Chaves Olarte E, Chacón Díaz C, Barquero Calvo E, et al. Neutrophils Dampen Adaptive Immunity in Brucellosis. Infect Immun. 2019;87: pubmed publisher
	Düsedau H, Kleveman J, Figueiredo C, Biswas A, Steffen J, Kliche S, et al. p75NTR regulates brain mononuclear cell function and neuronal structure in Toxoplasma infection-induced neuroinflammation. Glia. 2019;67:193-211 pubmed publisher
	Liu N, Luo J, Kuang D, Xu S, Duan Y, Xia Y, et al. Lactate inhibits ATP6V0d2 expression in tumor-associated macrophages to promote HIF-2α-mediated tumor progression. J Clin Invest. 2019;129:631-646 pubmed publisher
	Gubernatorova E, Gorshkova E, Namakanova O, Zvartsev R, Hidalgo J, Drutskaya M, et al. Non-redundant Functions of IL-6 Produced by Macrophages and Dendritic Cells in Allergic Airway Inflammation. Front Immunol. 2018;9:2718 pubmed publisher
	Rodriguez Cetina Biefer H, Heinbokel T, Uehara H, Camacho V, Minami K, Nian Y, et al. Mast cells regulate CD4+ T-cell differentiation in the absence of antigen presentation. J Allergy Clin Immunol. 2018;142:1894-1908.e7 pubmed publisher
	Meier L, Auger J, Engelson B, Cowan H, Breed E, Gonzalez Torres M, et al. CD301b/MGL2+ Mononuclear Phagocytes Orchestrate Autoimmune Cardiac Valve Inflammation and Fibrosis. Circulation. 2018;137:2478-2493 pubmed publisher
	Zamarron B, Mergian T, Cho K, Martinez Santibañez G, Luan D, Singer K, et al. Macrophage Proliferation Sustains Adipose Tissue Inflammation in Formerly Obese Mice. Diabetes. 2017;66:392-406 pubmed publisher
	Pangrazzi L, Meryk A, Naismith E, Koziel R, Lair J, Krismer M, et al. "Inflamm-aging" influences immune cell survival factors in human bone marrow. Eur J Immunol. 2017;47:481-492 pubmed publisher
	Fenton R, Molesworth Kenyon S, Oakes J, Lausch R. Linkage of IL-6 with neutrophil chemoattractant expression in virus-induced ocular inflammation. Invest Ophthalmol Vis Sci. 2002;43:737-43 pubmed

product information

Product Type :

Antibody

Product Name :

IL-6 Monoclonal Antibody (MP5 20F3)

Catalog # :

AMC0862

Quantity :

500 µg

Price :

US 375.00

Clonality :

Monoclonal

Purity :

purified

Host :

Rat

Reactivity :

Mouse

Applications :

ELISA: Assay-dependent, Flow Cytometry: Assay-dependent, Immunohistochemistry: Assay-dependent, Neutralization: Assay-dependent, Western Blot: Assay-dependent

Species :

Mouse

Clone :

MP5 20F3

Isotype :

IgG1, kappa

Storage :

-20°C

Description :

Interleukin 6 (IL-6) is a multifunctional 26 kD protein originally discovered in the medium of RNA-stimulated fibroblastoid cells. IL-6 appears to be directly involved in the responses that occur after infection and cellular injury, and it may prove to be important as IL-1 and TNF-a in regulating the acute phase response. IL-6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages and endothelial cells. IL-6 acts upon a variety of cells including myeloid progenitor cells, T cells, B cells, and hepatocytes. In addition, IL-6 appears to interact with IL-2 in the proliferation of T lymphocytes. IL-6 potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors. IL-6 plays a critical role in B-cell differentiation to plasma cells and is a potent growth factor for plasmacytoma and myeloma. IL-6 is a very useful culture supplement for the generation of a high number of antibody-producing hybridomas. Primarily produced at sites of acute and chronic inflammation, IL-6 is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of IL-6 is implicated in a wide variety of inflammation-associated disease states including diabetes mellitus and systemic juvenile rheumatoid arthritis.

Immunogen :

Recombinant mouse IL-6.

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Flow Cytometry: Assay-dependent, Immunohistochemistry: Assay-dependent, Neutralization: Assay-dependent, Western Blot: Assay-dependent

Aliases :

B-cell differentiation factor; B-cell hybridoma growth factor; B-cell stimulatory factor 2; BSF2; BSF-2; CDF; CHIL-6; CTL differentiation factor; cytokine; HGF; H-IL-6; HSF; hybridoma growth factor; Ifnb2; IFN-beta-2; Il6; IL-6; ILg6; ILN; interferon beta-2; Interleukin; interleukin 6; Interleukin 6 (interferon, beta 2); interleukin 6 precursor; interleukin BSF-2; interleukin HP-1; Interleukin6; Interleukin-6; interleukin-6 precursor; interleukin-6 protein; M-IL-6; prointerleukin 6; R-IL-6

more info or order :

Invitrogen product webpage