CDK5 Monoclonal Antibody (DC34) | Invitrogen AHZ0492 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CDK5 Monoclonal Antibody (DC34)

catalog :

AHZ0492

quantity :

500 µL

price :

US 496

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

DC34

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, immunoprecipitation

citations: 6

Reference
Mandl M, Zhang S, Ulrich M, Schmoeckel E, Mayr D, Vollmar A, et al. Inhibition of Cdk5 induces cell death of tumor-initiating cells. Br J Cancer. 2017;116:912-922 pubmed publisher
Merk H, Zhang S, Lehr T, MÃ¼ller C, Ulrich M, Bibb J, et al. Inhibition of endothelial Cdk5 reduces tumor growth by promoting non-productive angiogenesis. Oncotarget. 2016;7:6088-104 pubmed publisher
Liebl J, Zhang S, Moser M, Agalarov Y, Demir C, Hager B, et al. Cdk5 controls lymphatic vessel development and function by phosphorylation of Foxc2. Nat Commun. 2015;6:7274 pubmed publisher
de Nigris F, Mancini F, Schiano C, Infante T, Zullo A, Minucci P, et al. Osteosarcoma cells induce endothelial cell proliferation during neo-angiogenesis. J Cell Physiol. 2013;228:846-52 pubmed publisher
de Thonel A, Ferraris S, Pallari H, Imanishi S, Kochin V, Hosokawa T, et al. Protein kinase Czeta regulates Cdk5/p25 signaling during myogenesis. Mol Biol Cell. 2010;21:1423-34 pubmed publisher
Chauhan N. Effect of aged garlic extract on APP processing and tau phosphorylation in Alzheimer's transgenic model Tg2576. J Ethnopharmacol. 2006;108:385-94 pubmed

product information

Product Type :

Antibody

Product Name :

CDK5 Monoclonal Antibody (DC34)

Catalog # :

AHZ0492

Quantity :

500 µL

Price :

US 496

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: 5 µg/mL, Immunofluorescence: 5 µg/mL, Immunoprecipitation: Assay-Dependent, Western Blot: 1:500

Species :

Human, Mouse, Rat

Clone :

DC34

Isotype :

IgG1, kappa

Storage :

4° C

Description :

Cyclin-dependent kinase-5 (CDK5) is a member of the cyclin-dependent kinase family of serine/threonine kinases. Its mRNA and protein are expressed in the kidneys, testes, and ovaries. And Its activity has been detected almost exclusively in brain extracts. Similar to other Cdks, monomeric Cdk5 displays no enzymatic activity; however, Cdk5 is not activated bycyclins. Instead, Cdk5 activity requires association with one of two brain-specific regulatory subunits, called p35 and p39. These two activators regulate the spatial and temporal expression of active Cdk5, restricting its activity primarily to post-mitotic neurons.

Immunogen :

Recombinant cdk5 protein.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 5 µg/mL, Immunofluorescence: 5 µg/mL, Immunoprecipitation: Assay-Dependent, Western Blot: 1:500

Aliases :

AW048668; Cdk5; CDK5 activator 1; CDK5-SV; Cdkn5; Cell division protein kinase 5; CR6 protein kinase; Crk6; cyclin dependent kinase 5; cyclin-dependent kinase 5; cyclin-dependent-like kinase 5; LIS7; protein kinase CDK5 splicing; PSSALRE; Serine/threonine-protein kinase PSSALRE; tau protein kinase II catalytic subunit; TPKII catalytic subunit