p21 Monoclonal Antibody (HJ21) | Invitrogen AHZ0422 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

p21 Monoclonal Antibody (HJ21)

catalog :

AHZ0422

quantity :

100 µg

price :

US 500.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

HJ21

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry

citations: 12

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; mouse; loading ...; fig 5b	Lee S, Park K, Lee G, Kim S, Song W, Kwon S, et al. Hypoxia-inducible factor-2α mediates senescence-associated intrinsic mechanisms of age-related bone loss. Exp Mol Med. 2021;53:591-604 pubmed publisher
western blot; mouse; fig 5	Suvorova I, Grigorash B, Chuykin I, Pospelova T, Pospelov V. G1 checkpoint is compromised in mouse ESCs due to functional uncoupling of p53-p21Waf1 signaling. Cell Cycle. 2016;15:52-63 pubmed publisher
immunocytochemistry; human; 1:100; fig 6 western blot; human; 1:5000; fig 4	Pospelova T, Bykova T, Zubova S, Katolikova N, Yartzeva N, Pospelov V. Rapamycin induces pluripotent genes associated with avoidance of replicative senescence. Cell Cycle. 2013;12:3841-51 pubmed publisher
western blot; mouse; 1:50; fig 1	Romanov V, Bardin A, Zubova S, Bykova T, Pospelov V, Pospelova T. p21Waf1 is required for complete oncogenic transformation of mouse embryo fibroblasts by E1Aad5 and c-Ha-ras oncogenes. Biochimie. 2011;93:1408-14 pubmed publisher
	Wang J, Lu Y, Carr C, Dhandapani K, Brann D. Senolytic therapy is neuroprotective and improves functional outcome long-term after traumatic brain injury in mice. Front Neurosci. 2023;17:1227705 pubmed publisher
	Xiang X, Zhu J, Zhang G, Ma Z, Livingston M, Dong Z. Proximal Tubule p53 in Cold Storage/Transplantation-Associated Kidney Injury and Renal Graft Dysfunction. Front Med (Lausanne). 2021;8:746346 pubmed publisher
	Häseli S, Deubel S, Jung T, Grune T, Ott C. Cardiomyocyte Contractility and Autophagy in a Premature Senescence Model of Cardiac Aging. Oxid Med Cell Longev. 2020;2020:8141307 pubmed publisher
	Persia F, Troncoso M, Rinaldini E, Simirgiotis M, Tapia A, Borquez J, et al. UHPLC-Q/Orbitrap/MS/MS fingerprinting and antitumoral effects of Prosopis strombulifera (LAM.) BENTH. queous extract on allograft colorectal and melanoma cancer models. Heliyon. 2020;6:e03353 pubmed publisher
	Attaallah A, Lenzi M, Marchionni S, Bincoletto G, Cocchi V, Croco E, et al. A pro longevity role for cellular senescence. GeroScience. 2019;: pubmed publisher
	Ohmine S, Salisbury J, Ingle J, Pettinato G, Haddox C, Haddad T, et al. Aurora-A overexpression is linked to development of aggressive teratomas derived from human iPS cells. Oncol Rep. 2018;39:1725-1730 pubmed publisher
	Hrzenjak A, Moinfar F, Kremser M, Strohmeier B, Petru E, Zatloukal K, et al. Histone deacetylase inhibitor vorinostat suppresses the growth of uterine sarcomas in vitro and in vivo. Mol Cancer. 2010;9:49 pubmed publisher
	Stead E, White J, Faast R, Conn S, Goldstone S, Rathjen J, et al. Pluripotent cell division cycles are driven by ectopic Cdk2, cyclin A/E and E2F activities. Oncogene. 2002;21:8320-33 pubmed

product information

Product Type :

Antibody

Product Name :

p21 Monoclonal Antibody (HJ21)

Catalog # :

AHZ0422

Quantity :

100 µg

Price :

US 500.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: Assay-dependent, Western Blot: 1-2 µg/mL

Species :

Human, Mouse, Rat

Clone :

HJ21

Isotype :

IgG1

Storage :

4° C

Description :

Protein p21 is a tumor suppressor protein which is an inhibitor of Cyclin-dependent kinases (CDK) and is transcriptionally activated by p53. P21 is important in the response of cells to genotoxic stress and a major transcriptional target of p53 protein. The occurrence of p21 in the nucleus executes binding and inhibition activity of cyclin dependent kinases Cdk1 and Cdk2, and blocks the transition from G1 phase into S phase or from G2 phase into mitosis after DNA damage, which enables the repair of damaged DNA. In the cytoplasm, p21 protein has an anti-apoptotic effect. P21 is able to bind to and inhibit caspase 3, as well as the apoptotic kinases ASK1 and JNK. P21 exhibits a dual function in carcinogenesis, and acts as a tumor suppressor, prevents apoptosis, and acts as an oncogene.

Immunogen :

Human recombinant p21WAF1 protein.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: Assay-dependent, Western Blot: 1-2 µg/mL

Aliases :

Activating Fragment 1; CAP20; cdk inhibitor CIP1; cdk inhibitor CIP1 (p21); CDKI; CDK-interacting protein 1; CDK-interaction protein 1; Cdkn1; CDKN1A; CDNK1A; CIP1; Cip1); cyclin dependent kinase inhibitor 1A; cyclin-dependent kinase inhibitor 1; cyclin-dependent kinase inhibitor 1A; Cyclin-dependent kinase inhibitor 1A (p21; cyclin-dependent kinase inhibitor 1A (P21); cyclin-dependent kinase inhibitor 1A (p21, Cip1); cyclin-dependent kinase inhibitor 1A variant 1; cyclin-dependent kinase inhibitor 1A variant 2; DNA synthesis inhibitor; MDA6; MDA-6; melanoma differentiation associated protein 6; melanoma differentiation-associated protein; Melanoma differentiation-associated protein 6; OTTHUMP00000016298; p21; p21 ; p21Cip1; p21Cip1/Waf1; p21WAF; PIC1; putative cyclin-dependent kinase inhibitor 1A (p21/WAF1/CIP1); SDI1; SLC12A9; UV96; WAF1; Wild type p53 activated fragment 1 (WAF1); wild-type p53-activated fragment 1