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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
IL-6 Receptor Monoclonal Antibody (B-N12)
catalog :
AHR0961
quantity :
100 µg
price :
US 456.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
B-N12
reactivity :
human
application :
ELISA, flow cytometry
more info or order :
Invitrogen product webpage
citations: 2
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; fig 1
Cervello M, Notarbartolo M, Landino M, Cusimano A, Virruso L, Montalto G, et al. Downregulation of wild-type beta-catenin expression by interleukin 6 in human hepatocarcinoma HepG2 cells: a possible role in the growth-regulatory effects of the cytokine?. Eur J Cancer. 2001;37:512-9 pubmed
  • flow cytometry; human; fig 2
Bank U, Reinhold D, Schneemilch C, Kunz D, Synowitz H, Ansorge S. Selective proteolytic cleavage of IL-2 receptor and IL-6 receptor ligand binding chains by neutrophil-derived serine proteases at foci of inflammation. J Interferon Cytokine Res. 1999;19:1277-87 pubmed
product information
Product Type :
Antibody
Product Name :
IL-6 Receptor Monoclonal Antibody (B-N12)
Catalog # :
AHR0961
Quantity :
100 µg
Price :
US 456.00
Clonality :
Monoclonal
Purity :
purified
Host :
Mouse
Reactivity :
Human
Applications :
ELISA: Assay-dependent, Flow Cytometry: Assay-dependent
Species :
Human
Clone :
B-N12
Isotype :
IgG1, kappa
Storage :
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Description :
Interleukin 6 receptor (IL6R), also known as CD126 (Cluster of Differentiation 126), is a type I cytokine receptor. This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.
Immunogen :
CHO cells transfected with cDNA produced from the gp80 IL-6 receptor mRNA.
Format :
Liquid
Applications w/Dilutions :
ELISA: Assay-dependent, Flow Cytometry: Assay-dependent
Aliases :
CD126; CD126 antigen; gp80; IL-6 Receptor; il-6 receptor alpha; IL-6 receptor alpha chain; IL-6 receptor subunit alpha; IL6Q; IL6R; IL-6R; IL-6R 1; IL-6R subunit alpha; IL6R1; IL-6R-1; Il6ra; IL-6RA; IL-6R-alpha; IL6RQ; ILN; Interleukin; interleukin 6 receptor; interleukin 6 receptor, alpha; interleukin-6 receptor subunit alpha; Membrane glycoprotein 80; MGC104991
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA