IGF1R alpha Monoclonal Antibody (24-31) | Invitrogen AHR0321 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IGF1R alpha Monoclonal Antibody (24-31)

catalog :

AHR0321

quantity :

500 µL

price :

US 506.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

24-31

reactivity :

human

application :

ELISA, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 8

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - frozen section; human; 1:100; fig 4b immunocytochemistry; human; 4 ug/ml; loading ...; fig 1b	Park J, Lee J, Zhang Y, Hoffman R, Bouvet M. Targeting the insulin growth factor-1 receptor with fluorescent antibodies enables high resolution imaging of human pancreatic cancer in orthotopic mouse models. Oncotarget. 2016;7:18262-8 pubmed publisher
immunocytochemistry; human; loading ...; fig 1b	Park J, Murakami T, Lee J, Zhang Y, Hoffman R, Bouvet M. Fluorescent-Antibody Targeting of Insulin-Like Growth Factor-1 Receptor Visualizes Metastatic Human Colon Cancer in Orthotopic Mouse Models. PLoS ONE. 2016;11:e0146504 pubmed publisher
immunohistochemistry - paraffin section; human; 1:25	Liu J, Druta M, Shibata D, Coppola D, Boler I, Elahi A, et al. Metabolic syndrome and colorectal cancer: is hyperinsulinemia/insulin receptor-mediated angiogenesis a critical process?. J Geriatr Oncol. 2014;5:40-8 pubmed publisher
immunohistochemistry - paraffin section; human; 1:200; fig 1	Gallardo A, Lerma E, Escuin D, Tibau A, Munoz J, Ojeda B, et al. Increased signalling of EGFR and IGF1R, and deregulation of PTEN/PI3K/Akt pathway are related with trastuzumab resistance in HER2 breast carcinomas. Br J Cancer. 2012;106:1367-73 pubmed publisher
immunohistochemistry - paraffin section; human; 1:50; tbl 1	Langner C, Ratschek M, Rehak P, Tsybrovskyy O, Zigeuner R. The pT1a and pT1b category subdivision in renal cell carcinoma: is it reflected by differences in tumour biology?. BJU Int. 2005;95:310-4 pubmed
	Han K, Pierce S, Li A, Spees K, Anderson G, Seoane J, et al. CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities. Nature. 2020;580:136-141 pubmed publisher
	Mountzios G, Aivazi D, Kostopoulos I, Kourea H, Kouvatseas G, Timotheadou E, et al. Differential expression of the insulin-like growth factor receptor among early breast cancer subtypes. PLoS ONE. 2014;9:e91407 pubmed publisher
	Henriksen K, Rasmussen B, Lykkesfeldt A, Møller S, Ejlertsen B, Mouridsen H. An ER activity profile including ER, PR, Bcl-2 and IGF-IR may have potential as selection criterion for letrozole or tamoxifen treatment of patients with advanced breast cancer. Acta Oncol. 2009;48:522-31 pubmed publisher

product information

Product Type :

Antibody

Product Name :

IGF1R alpha Monoclonal Antibody (24-31)

Catalog # :

AHR0321

Quantity :

500 µL

Price :

US 506.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human

Applications :

ELISA: Assay-dependent, Immunocytochemistry: 1:10-1:100, Immunoprecipitation: 2 µg / mg lysate

Species :

Human

Clone :

24-31

Isotype :

IgG1

Storage :

4° C

Description :

IGF1R (Insulin-like Growth Factor1 Receptor) is a receptor tyrosine kinase that mediates actions of insulin-like growth factor 1 (IFG1). It binds IGF1 with high affinity and IGF2/insulin with lower affinity. Activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survial of malignant cells. Ligand binding activates the receptor kinase and leads to receptor autophosphorylation and tyrosines phosphorylation of multiple substrates that function as signaling adapter proteins.

Immunogen :

IGF-1R/3T3 mouse fibroblasts transfected with human type 1 IGF-receptor cDNA.

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Immunocytochemistry: 1:10-1:100, Immunoprecipitation: 2 µg / mg lysate

Aliases :

A330103N21Rik; CD221; D930020L01; hyft; IGF-1 receptor; Igf1r; IGF-1R; IGF-I receptor; IGFIR; IGFIRC; IGFR; Igfr1; insulin like growth factor 1 receptor; insulin-like growth factor 1 receptor; Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain; insulin-like growth factor 1 receptor beta subunit; insulin-like growth factor I receptor; insulin-like growth factor receptor 1; insulin-like growth factor-I receptor; insulin-like growth factor-I receptor precursor; JTK13; line 186; soluble IGF1R variant 1; soluble IGF1R variant 2

more info or order :

Invitrogen product webpage