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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
INSR beta Monoclonal Antibody (CT-3)
catalog :
AHR0271
quantity :
500 µL
price :
US 496.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
CT-3
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
Invitrogen product webpage
citations: 12
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; mouse; fig 2
Roudnicky F, Dieterich L, Poyet C, Buser L, Wild P, Tang D, et al. High expression of insulin receptor on tumour-associated blood vessels in invasive bladder cancer predicts poor overall and progression-free survival. J Pathol. 2017;242:193-205 pubmed publisher
  • immunohistochemistry - frozen section; rat; 4 ug/ml; fig 8
Aimé P, Hegoburu C, Jaillard T, Degletagne C, Garcia S, Messaoudi B, et al. A physiological increase of insulin in the olfactory bulb decreases detection of a learned aversive odor and abolishes food odor-induced sniffing behavior in rats. PLoS ONE. 2012;7:e51227 pubmed publisher
  • western blot; rat
Sharma N, Arias E, Sequea D, Cartee G. Preventing the calorie restriction-induced increase in insulin-stimulated Akt2 phosphorylation eliminates calorie restriction's effect on glucose uptake in skeletal muscle. Biochim Biophys Acta. 2012;1822:1735-40 pubmed publisher
  • western blot; rat; 1:1000; fig 3
Sequea D, Sharma N, Arias E, Cartee G. Calorie restriction enhances insulin-stimulated glucose uptake and Akt phosphorylation in both fast-twitch and slow-twitch skeletal muscle of 24-month-old rats. J Gerontol A Biol Sci Med Sci. 2012;67:1279-85 pubmed publisher
  • western blot; mouse; fig 2
Xiao Y, Sharma N, Arias E, Castorena C, Cartee G. A persistent increase in insulin-stimulated glucose uptake by both fast-twitch and slow-twitch skeletal muscles after a single exercise session by old rats. Age (Dordr). 2013;35:573-82 pubmed
  • western blot; human; fig 2
Kasuga K, Kaneko H, Nishizawa M, Onodera O, Ikeuchi T. Generation of intracellular domain of insulin receptor tyrosine kinase by gamma-secretase. Biochem Biophys Res Commun. 2007;360:90-6 pubmed
  • ELISA; human; 0.75 ug/ml
Garcia Echeverria C, Pearson M, Marti A, Meyer T, Mestan J, Zimmermann J, et al. In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase. Cancer Cell. 2004;5:231-9 pubmed
Hsieh M, Choe J, Gadhvi J, Kim Y, Arguez M, Palmer M, et al. p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas. Cell Rep. 2019;28:1860-1878.e9 pubmed publisher
Al Koborssy D, Palouzier Paulignan B, Canova V, Thevenet M, Fadool D, Julliard A. Modulation of olfactory-driven behavior by metabolic signals: role of the piriform cortex. Brain Struct Funct. 2019;224:315-336 pubmed publisher
Hopkins B, Pauli C, Du X, Wang D, Li X, Wu D, et al. Suppression of insulin feedback enhances the efficacy of PI3K inhibitors. Nature. 2018;560:499-503 pubmed publisher
Corbin J, Bhaskar V, Goldfine I, Issafras H, Bedinger D, Lau A, et al. Inhibition of insulin receptor function by a human, allosteric monoclonal antibody: a potential new approach for the treatment of hyperinsulinemic hypoglycemia. MAbs. 2014;6:262-72 pubmed publisher
Dismukes R, Ghosh P, Creveling C, Daly J. Altered responsiveness of adenosine 3',5'-monophosphate-generating systems in rat cortical slices after lesions of the medial forebran bundle. Exp Neurol. 1975;49:725-35 pubmed
product information
Product Type :
Antibody
Product Name :
INSR beta Monoclonal Antibody (CT-3)
Catalog # :
AHR0271
Quantity :
500 µL
Price :
US 496.00
Clonality :
Monoclonal
Purity :
Protein G
Host :
Mouse
Reactivity :
Human, Mouse
Applications :
ELISA: Assay-dependent, Immunocytochemistry: 1:10-1:100, Immunohistochemistry (Paraffin): Assay-Dependent, Western Blot: 1:25-1:50
Species :
Human, Mouse
Clone :
CT-3
Isotype :
IgG1
Storage :
4° C
Description :
Biological actions of insulin and IGF-1 are mediated by their respective cell surface receptor tyrosine kinases that regulate multiple signaling pathways through activation of a series of phosphorylation cascades. The insulin receptor. Insulin/IGF-1 binding to the extracellular domain leads to autophosphorylation of downstream target proteins. These two receptors differ in sequence in regions that confer specificity for the designated ligand as well as in certain intracellular signaling domains, resulting in significant differences in the functional consequences of activation of each receptor. Defects in IR are the cause of various insulin resistance syndromes and IGF-1R defects may cause some forms of growth retardation. Both these signaling cascades are also important for the development of cancer.
Immunogen :
Recombinant fragment including the C-terminal 100 amino acid residues of human insulin receptor.
Format :
Liquid
Applications w/Dilutions :
ELISA: Assay-dependent, Immunocytochemistry: 1:10-1:100, Immunohistochemistry (Paraffin): Assay-Dependent, Western Blot: 1:25-1:50
Aliases :
4932439J01Rik; CD220; CD220 beta; CD221; D630014A15Rik; HHF5; IGF-I receptor; Insr; Insulin receptor; insulin receptor preproprotein; Insulin receptor subunit alpha; Insulin receptor subunit beta; IR; IR beta; IR-A; IR-B
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA