INSR alpha Monoclonal Antibody (83-7) | Invitrogen AHR0231 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

INSR alpha Monoclonal Antibody (83-7)

catalog :

AHR0231

quantity :

500 uL

price :

US 542.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

83-7

reactivity :

human, bovine, pigs , domestic sheep, domestic rabbit

application :

immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

citations: 3

Reference
Guo X, Asthana P, Gurung S, Zhang S, Wong S, Fallah S, et al. Regulation of age-associated insulin resistance by MT1-MMP-mediated cleavage of insulin receptor. Nat Commun. 2022;13:3749 pubmed publisher
Jeong M, Rutter J, Chou D. Display of Single-Chain Insulin-like Peptides on a Yeast Surface. Biochemistry. 2019;58:182-188 pubmed publisher
Yuasa T, Amo Shiinoki K, Ishikura S, Takahara M, Matsuoka T, Kaneto H, et al. Sequential cleavage of insulin receptor by calpain 2 and Î³-secretase impairs insulin signalling. Diabetologia. 2016;59:2711-2721 pubmed

product information

Product Type :

Antibody

Product Name :

INSR alpha Monoclonal Antibody (83-7)

Catalog # :

AHR0231

Quantity :

500 uL

Price :

US 542.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Bovine, Human, Ovine, Porcine, Rabbit

Applications :

ELISA: Assay-dependent, Flow Cytometry: Assay-Dependent, Immunocytochemistry: 1:10-1:100, Immunohistochemistry (Frozen): 2-4 ug/mL, Immunohistochemistry (Paraffin): 2-4 ug/mL

Species :

Bovine, Human, Ovine, Porcine, Rabbit

Clone :

83-7

Isotype :

IgG1, kappa

Storage :

4 C

Description :

Biological actions of insulin and IGF-1 are mediated by their respective cell surface receptor tyrosine kinases that regulate multiple signaling pathways through activation of a series of phosphorylation cascades. The insulin receptor. Insulin/IGF-1 binding to the extracellular domain leads to autophosphorylation of downstream target proteins. These two receptors differ in sequence in regions that confer specificity for the designated ligand as well as in certain intracellular signaling domains, resulting in significant differences in the functional consequences of activation of each receptor. Defects in IR are the cause of various insulin resistance syndromes and IGF-1R defects may cause some forms of growth retardation. Both these signaling cascades are also important for the development of cancer.

Immunogen :

IM-9 lymphocytes followed by purified insulin receptor.

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Flow Cytometry: Assay-Dependent, Immunocytochemistry: 1:10-1:100, Immunohistochemistry (Frozen): 2-4 ug/mL, Immunohistochemistry (Paraffin): 2-4 ug/mL

Aliases :

4932439J01Rik; CD220; CD220 beta; D630014A15Rik; DAF-2; HHF5; INSR; insulin receptor; insulin receptor (INSR); insulin receptor precursor; insulin receptor preproprotein; Insulin receptor subunit alpha; Insulin receptor subunit beta; IR; IR alpha; IR beta; ir-A; IR-B