JAK2 Monoclonal Antibody (691R5) | Invitrogen AHO1352 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

JAK2 Monoclonal Antibody (691R5)

catalog :

AHO1352

quantity :

100 µg

price :

US 430.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

691R5

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, immunoprecipitation

more info or order :

Invitrogen product webpage

citations: 12

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; fig 1	Nespital T, van der Velden L, Mensinga A, van der Vaart E, Strous G. Fos-Zippered GH Receptor Cytosolic Tails Act as Jak2 Substrates and Signal Transducers. Mol Endocrinol. 2016;30:290-301 pubmed publisher
western blot; human; fig 4	Nespital T, Strous G. The Jak/STAT signaling pathway is downregulated at febrile temperatures. PLoS ONE. 2012;7:e49374 pubmed publisher
immunocytochemistry; human	Tao J, Oladimeji P, Rider L, Diakonova M. PAK1-Nck regulates cyclin D1 promoter activity in response to prolactin. Mol Endocrinol. 2011;25:1565-78 pubmed publisher
immunoprecipitation; human; fig 3 western blot; human; fig 3	Putters J, da Silva Almeida A, van Kerkhof P, van Rossum A, Gracanin A, Strous G. Jak2 is a negative regulator of ubiquitin-dependent endocytosis of the growth hormone receptor. PLoS ONE. 2011;6:e14676 pubmed publisher
western blot; mouse; 1:2000; fig s2	Sakamoto K, Triplett A, Schuler L, Wagner K. Janus kinase 2 is required for the initiation but not maintenance of prolactin-induced mammary cancer. Oncogene. 2010;29:5359-69 pubmed publisher
western blot; mouse; 1:200; fig 2	Berthier C, Zhang H, Schin M, Henger A, Nelson R, Yee B, et al. Enhanced expression of Janus kinase-signal transducer and activator of transcription pathway members in human diabetic nephropathy. Diabetes. 2009;58:469-77 pubmed publisher
western blot; human; fig 2	Rider L, Shatrova A, Feener E, Webb L, Diakonova M. JAK2 tyrosine kinase phosphorylates PAK1 and regulates PAK1 activity and functions. J Biol Chem. 2007;282:30985-96 pubmed
	Wang R, Wang Y, Liao G, Chen B, Panettieri R, Penn R, et al. Abi1 mediates airway smooth muscle cell proliferation and airway remodeling via Jak2/STAT3 signaling. iScience. 2022;25:103833 pubmed publisher
	Cortizo F, Pfaff D, Wirth A, Schlotterer A, Medert R, Morgenstern J, et al. The activity of glyoxylase 1 is regulated by glucose-responsive phosphorylation on Tyr136. Mol Metab. 2022;55:101406 pubmed publisher
	Li M, Gao J, Li D, Yin Y. CEP55 Promotes Cell Motility via JAK2?STAT3?MMPs Cascade in Hepatocellular Carcinoma. Cells. 2018;7: pubmed publisher
	Hammer A, Rider L, Oladimeji P, Cook L, Li Q, Mattingly R, et al. Tyrosyl phosphorylated PAK1 regulates breast cancer cell motility in response to prolactin through filamin A. Mol Endocrinol. 2013;27:455-65 pubmed publisher
	Rider L, Tao J, Snyder S, Brinley B, Lu J, Diakonova M. Adapter protein SH2B1beta cross-links actin filaments and regulates actin cytoskeleton. Mol Endocrinol. 2009;23:1065-76 pubmed publisher

product information

Product Type :

Antibody

Product Name :

JAK2 Monoclonal Antibody (691R5)

Catalog # :

AHO1352

Quantity :

100 µg

Price :

US 430.00

Clonality :

Monoclonal

Purity :

purified

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

Western Blot: Assay-dependent

Species :

Human, Mouse, Rat

Clone :

691R5

Isotype :

IgG2b, kappa

Storage :

-20°C

Description :

Janus kinase 2 (JAK2) is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways and is mutated in polycythemia vera. This kinase contains the catalytic domain (JH1) of JAK2. The activation of JAKs can lead to the phosphorylation of STAT (signal transducers and activatiors of transcription) proteins, which dimerize and translocate to the nucleus. Once translocated to the nucleus, the STAT proteins can modify transcription of numerous genes, including interferon-stimulated genes. JAK2 is required for the IFN gamma-receptor complex initiation and JAK1 functions as an amplifier. Some studies have suggested that the role of JAK2 might be performed by Tyk2 and JAK3, if they were positioned correctly within the IFN gamma-receptor complex. Mutations affecting JAK2 can cause Budd-Chiari syndrome, Polycythemia vera, Thrombocythemia 3, myelofibrosis, or Acute myelogenous leukemia.

Immunogen :

Recombinant fragment of human JAK2 expressed in E. coli.

Format :

Liquid

Applications w/Dilutions :

Western Blot: Assay-dependent

Aliases :

EC 2.7.10.2; Fd17; JAK 2; JAK2; JAK-2; Janus kinase 2; Janus kinase 2 (a protein tyrosine kinase); JTK 10; JTK10; kinase Jak2; THCYT3; Tyrosine-protein kinase JAK2

more info or order :

Invitrogen product webpage