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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
FAK Polyclonal Antibody
catalog :
AHO0502
quantity :
500 µg
price :
US 500.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunoprecipitation
more info or order :
Invitrogen product webpage
citations: 18
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; fig 6a
  • western blot; mouse; fig 6e
Peng D, Ungewiss C, Tong P, Byers L, Wang J, Canales J, et al. ZEB1 induces LOXL2-mediated collagen stabilization and deposition in the extracellular matrix to drive lung cancer invasion and metastasis. Oncogene. 2017;36:1925-1938 pubmed publisher
  • western blot; mouse; fig 5
Ungewiss C, Rizvi Z, Roybal J, Peng D, Gold K, Shin D, et al. The microRNA-200/Zeb1 axis regulates ECM-dependent β1-integrin/FAK signaling, cancer cell invasion and metastasis through CRKL. Sci Rep. 2016;6:18652 pubmed publisher
M xe4 kinen S, Datta N, Rangarajan S, Nguyen Y, Olkkonen V, Latva Rasku A, et al. Finnish-specific AKT2 gene variant leads to impaired insulin signalling in myotubes. J Mol Endocrinol. 2023;70: pubmed publisher
Chen C, Wu P, Van Scoyk M, Simko S, Chou C, Winn R. KCNF1 promotes lung cancer by modulating ITGB4 expression. Cancer Gene Ther. 2023;30:414-423 pubmed publisher
Betriu N, Andreeva A, Alonso A, Semino C. Increased Stiffness Downregulates Focal Adhesion Kinase Expression in Pancreatic Cancer Cells Cultured in 3D Self-Assembling Peptide Scaffolds. Biomedicines. 2022;10: pubmed publisher
Lee J, Ng H, Lin Y, Lin T, Kao C, Shie M. The Synergistic Effect of Cyclic Tensile Force and Periodontal Ligament Cell-Laden Calcium Silicate/Gelatin Methacrylate Auxetic Hydrogel Scaffolds for Bone Regeneration. Cells. 2022;11: pubmed publisher
Reed D, Zhao Y, Han M, Mercuri L, Miloro M. Mechanical Loading Disrupts Focal Adhesion Kinase Activation in Mandibular Fibrochondrocytes During Murine Temporomandibular Joint Osteoarthritis. J Oral Maxillofac Surg. 2021;79:2058.e1-2058.e15 pubmed publisher
Chanez B, Ostacolo K, Badache A, Thuault S. EB1 Restricts Breast Cancer Cell Invadopodia Formation and Matrix Proteolysis via FAK. Cells. 2021;10: pubmed publisher
Lin J, Huang Y, Chen Y, Chuang T, Lan T, Liu Y, et al. Dexamethasone accelerates muscle regeneration by modulating kinesin-1-mediated focal adhesion signals. Cell Death Discov. 2021;7:35 pubmed publisher
Atsumi S, Katoh H, Komura D, Hashimoto I, Furuya G, Koda H, et al. Focal adhesion ribonucleoprotein complex proteins are major humoral cancer antigens and targets in autoimmune diseases. Commun Biol. 2020;3:588 pubmed publisher
Bommareddy R, Patel R, Smalley T, Acevedo Duncan M. Effects of Atypical Protein Kinase C Inhibitor (DNDA) on Lung Cancer Proliferation and Migration by PKC-ι/FAK Ubiquitination Through the Cbl-b Pathway. Onco Targets Ther. 2020;13:1661-1676 pubmed publisher
Li Y, Jiang G, Chen L, Jiang Y, Jiao J. Formin mDia1 contributes to migration and epithelial-mesenchymal transition of tubular epithelial cells exposed to TGF-β1. J Cell Biochem. 2020;121:3861-3870 pubmed publisher
Raman A, Parnell S, Zhang Y, Reif G, Dai Y, Khanna A, et al. Periostin overexpression in collecting ducts accelerates renal cyst growth and fibrosis in polycystic kidney disease. Am J Physiol Renal Physiol. 2018;315:F1695-F1707 pubmed publisher
Böhm B, Fehrl Y, Janczi T, Schneider N, Burkhardt H. Cell adhesion-induced transient interaction of ADAM15 with poly(A) binding protein at the cell membrane colocalizes with mRNA translation. PLoS ONE. 2018;13:e0203847 pubmed publisher
Hsiao C, Cheng H, Huang C, Li H, Ou M, Huang J, et al. Fibronectin in cell adhesion and migration via N-glycosylation. Oncotarget. 2017;8:70653-70668 pubmed publisher
Jaraíz Rodríguez M, Tabernero M, González Tablas M, Otero A, Orfao A, Medina J, et al. A Short Region of Connexin43 Reduces Human Glioma Stem Cell Migration, Invasion, and Survival through Src, PTEN, and FAK. Stem Cell Reports. 2017;9:451-463 pubmed publisher
Atherton P, Lausecker F, Harrison A, Ballestrem C. Low-intensity pulsed ultrasound promotes cell motility through vinculin-controlled Rac1 GTPase activity. J Cell Sci. 2017;130:2277-2291 pubmed publisher
Wu J, Chen Y, Kuo C, Wenshin Yu H, Chen Y, Chiou A, et al. Focal adhesion kinase-dependent focal adhesion recruitment of SH2 domains directs SRC into focal adhesions to regulate cell adhesion and migration. Sci Rep. 2015;5:18476 pubmed publisher
product information
Product Type :
Antibody
Product Name :
FAK Polyclonal Antibody
Catalog # :
AHO0502
Quantity :
500 µg
Price :
US 500.00
Clonality :
Polyclonal
Purity :
protein A
Host :
Rabbit
Reactivity :
Human, Mouse, Rat
Applications :
Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent
Species :
Human, Mouse, Rat
Isotype :
IgG
Storage :
-20°C
Description :
Focal Adhesion Kinase (FAK) is a 125 kDa non-receptor protein tyrosine kinase that acts as a substrate for Src and is a key element of integrin signaling. FAK plays an important role in cell spreading, differentiation, migration, cell death, and acceleration of the G1 to S phase transition of the cell cycle. FAK has a central catalytic domain and a C-terminal tail that localizes it to focal adhesions, which are sites where cells attach to the extracellular matrix via surface integrin receptors. Increased FAK tyrosine phosphorylation occurs upon integrin engagement with fibronectin. Adhesion of murine NIH3T3 fibroblasts to fibronectin promotes association of the Grb2 adapter protein and c-Src PTK with FAK in vivo, and also results in activation of the ERK2 MAP kinase. In v-Src-transformed NIH3T3, the association of v-Src, Grb2, and Sos with FAK is independent of cell adhesion to fibronectin. In vitro the Grb2 SH2 domain binds directly to tyrosine-phosphorylated FAK, and the binding site has been identified as Tyr925 by site directed mutagenesis. Several transcript variants encoding different isoforms have been found for the FAK gene, but the full-length natures of only three of them have been determined.
Immunogen :
Recombinant protein corresponding to amino acid residues 853-1052 from theC-terminal region of human FAK.
Format :
Liquid
Applications w/Dilutions :
Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent
Aliases :
CG10023; CG10023-PA; CG10023-PB; CG10023-PC; CG10023-PD; CG10023-PF; CG10023-PG; CT28129; DFAK; DFak56; Dmel CG10023; Dmel_CG10023; DmFAK; EC 2.7.10.2; Fadk; FADK 1; Fak; Fak1; Fak56; fak56D; FAK65D; Fak-PA; Fak-PB; Fak-PC; Fak-PD; Fak-PF; Fak-PG; FAK-related non-kinase polypeptide; focal adhesion kinase; Focal adhesion kinase 1; focal adhesion kinase homolog; focal adhesion kinase isoform FAK-Del33; focal adhesion kinase pp125FAK; focal adhesion kinase-related nonkinase; focal ashension kinase 1; FRNK; I79_019430; Kiaa4203; mKIAA4203; p125FAK; p41/p43FRNK; pFAK; pp125 PTK2; pp125FAK; PPP1R71; Protein phosphatase 1 regulatory subunit 71; protein phosphatase 1, regulatory subunit 71; protein tyrosine kinase 2; protein tyrosine kinase 2 L homeolog; protein-tyrosine kinase; protein-tyrosine kinase 2; PTK2; PTK2 protein tyrosine kinase 2; ptk2.L; tyrosine kinase; XELAEV_18032408mg; XPFAK
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA