This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
c-Myc Monoclonal Antibody (9E10.3)
catalog :
AHO0062
quantity :
500 uL
price :
US 458.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
9E10.3

The same clone is also sold as:
reactivity :
human
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, chromatin immunoprecipitation, immunohistochemistry - paraffin section
citations: 39
Reference
Singh Babak S, Babak T, Fraser H, Johnson A. Lineage-specific selection and the evolution of virulence in the Candida clade. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
Jiang T, Mu B, Zhao R. Plastid chaperone HSP90C guides precursor proteins to the SEC translocase for thylakoid transport. J Exp Bot. 2020;71:7073-7087 pubmed publisher
Liu Y, Zhang H, Li X, Zhang C, Huang H. Identification of anti-tumoral feedback loop between VHLα and hnRNPA2B1 in renal cancer. Cell Death Dis. 2020;11:688 pubmed publisher
Hu P, Zhao H, Zhu P, Xiao Y, Miao W, Wang Y, et al. Dual regulation of Arabidopsis AGO2 by arginine methylation. Nat Commun. 2019;10:844 pubmed publisher
Garcia P, Miller A, Gamblin T, Council L, Christein J, Arnoletti J, et al. JQ1 Induces DNA Damage and Apoptosis, and Inhibits Tumor Growth in a Patient-Derived Xenograft Model of Cholangiocarcinoma. Mol Cancer Ther. 2018;17:107-118 pubmed publisher
Macia M, Halbritter J, Delous M, Bredrup C, Gutter A, Filhol E, et al. Mutations in MAPKBP1 Cause Juvenile or Late-Onset Cilia-Independent Nephronophthisis. Am J Hum Genet. 2017;100:323-333 pubmed publisher
Derussy B, Boland M, Tandon R. Human Cytomegalovirus pUL93 Links Nucleocapsid Maturation and Nuclear Egress. J Virol. 2016;90:7109-7117 pubmed publisher
Ramena G, Yin Y, Yu Y, Walia V, Elble R. CLCA2 Interactor EVA1 Is Required for Mammary Epithelial Cell Differentiation. PLoS ONE. 2016;11:e0147489 pubmed publisher
Hernday A, Lohse M, Nobile C, Noiman L, Laksana C, Johnson A. Ssn6 Defines a New Level of Regulation of White-Opaque Switching in Candida albicans and Is Required For the Stochasticity of the Switch. MBio. 2016;7:e01565-15 pubmed publisher
Lohse M, Johnson A. Identification and Characterization of Wor4, a New Transcriptional Regulator of White-Opaque Switching. G3 (Bethesda). 2016;6:721-9 pubmed publisher
Sun X, Li P, Zhu S, Cohen R, Marque L, Ross C, et al. Nuclear retention of full-length HTT RNA is mediated by splicing factors MBNL1 and U2AF65. Sci Rep. 2015;5:12521 pubmed publisher
Garcia P, Miller A, Kreitzburg K, Council L, Gamblin T, Christein J, et al. The BET bromodomain inhibitor JQ1 suppresses growth of pancreatic ductal adenocarcinoma in patient-derived xenograft models. Oncogene. 2016;35:833-45 pubmed publisher
Ambavaram M, Basu S, Krishnan A, Ramegowda V, Batlang U, Rahman L, et al. Coordinated regulation of photosynthesis in rice increases yield and tolerance to environmental stress. Nat Commun. 2014;5:5302 pubmed publisher
Schofield A, Gamell C, Bernard O. Tubulin polymerization promoting protein 1 (TPPP1) increases ?-catenin expression through inhibition of HDAC6 activity in U2OS osteosarcoma cells. Biochem Biophys Res Commun. 2013;436:571-7 pubmed publisher
Novellino L, Rossi R, Bonino F, Cavallone D, Abrignani S, Pagani M, et al. Circulating hepatitis B surface antigen particles carry hepatocellular microRNAs. PLoS ONE. 2012;7:e31952 pubmed publisher
Giaginis C, Politi E, Alexandrou P, Sfiniadakis J, Kouraklis G, Theocharis S. Expression of peroxisome proliferator activated receptor-gamma (PPAR-?) in human non-small cell lung carcinoma: correlation with clinicopathological parameters, proliferation and apoptosis related molecules and patients' survival. Pathol Oncol Res. 2012;18:875-83 pubmed
Huang Y, Chiang N, Hu C, Hsiao C, Cheng K, Tsai W, et al. Activation of myeloid cell-specific adhesion class G protein-coupled receptor EMR2 via ligation-induced translocation and interaction of receptor subunits in lipid raft microdomains. Mol Cell Biol. 2012;32:1408-20 pubmed publisher
Lanham K, Prasch A, Weina K, Peterson R, Heideman W. A dominant negative zebrafish Ahr2 partially protects developing zebrafish from dioxin toxicity. PLoS ONE. 2011;6:e28020 pubmed publisher
Challagundla K, Sun X, Zhang X, Devine T, Zhang Q, Sears R, et al. Ribosomal protein L11 recruits miR-24/miRISC to repress c-Myc expression in response to ribosomal stress. Mol Cell Biol. 2011;31:4007-21 pubmed publisher
Nobile C, Nett J, Hernday A, Homann O, Deneault J, Nantel A, et al. Biofilm matrix regulation by Candida albicans Zap1. PLoS Biol. 2009;7:e1000133 pubmed publisher
Yang L, Shen L, Shao Y, Zhao Q, Zhang W. Cytoplasmic domain of human Fcalpha/mu receptor is required for ligand internalization. Cell Immunol. 2009;258:78-82 pubmed publisher
Katzenellenbogen R, Vliet Gregg P, Xu M, Galloway D. NFX1-123 increases hTERT expression and telomerase activity posttranscriptionally in human papillomavirus type 16 E6 keratinocytes. J Virol. 2009;83:6446-56 pubmed publisher
Kong D, Song S, Kim D, Joo K, Yoo J, Koh J, et al. Prognostic significance of c-Met expression in glioblastomas. Cancer. 2009;115:140-8 pubmed publisher
Itahana K, Zhang Y. Mitochondrial p32 is a critical mediator of ARF-induced apoptosis. Cancer Cell. 2008;13:542-53 pubmed publisher
Olzmann J, Li L, Chudaev M, Chen J, Perez F, Palmiter R, et al. Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6. J Cell Biol. 2007;178:1025-38 pubmed
Kilianova Z, Basora N, Kilian P, Payet M, Gallo Payet N. Human melanocortin receptor 2 expression and functionality: effects of protein kinase A and protein kinase C on desensitization and internalization. Endocrinology. 2006;147:2325-37 pubmed
O Donnell K, Wentzel E, Zeller K, Dang C, Mendell J. c-Myc-regulated microRNAs modulate E2F1 expression. Nature. 2005;435:839-43 pubmed
Davis M, Ireton R, Reynolds A. A core function for p120-catenin in cadherin turnover. J Cell Biol. 2003;163:525-34 pubmed
Kefas B, Cai Y, Ling Z, Heimberg H, Hue L, Pipeleers D, et al. AMP-activated protein kinase can induce apoptosis of insulin-producing MIN6 cells through stimulation of c-Jun-N-terminal kinase. J Mol Endocrinol. 2003;30:151-61 pubmed
Baker Lepain J, Sarzotti M, Fields T, Li C, Nicchitta C. GRP94 (gp96) and GRP94 N-terminal geldanamycin binding domain elicit tissue nonrestricted tumor suppression. J Exp Med. 2002;196:1447-59 pubmed
Hitzl M, Striessnig J, Neuhuber B, Flucher B. A mutation in the beta interaction domain of the Ca(2+) channel alpha(1C) subunit reduces the affinity of the (+)-[(3)H]isradipine binding site. FEBS Lett. 2002;524:188-92 pubmed
Piechocki M, Pilon S, Wei W. Quantitative measurement of anti-ErbB-2 antibody by flow cytometry and ELISA. J Immunol Methods. 2002;259:33-42 pubmed
Thiebot H, Louache F, Vaslin B, de Revel T, Neildez O, Larghero J, et al. Early and persistent bone marrow hematopoiesis defect in simian/human immunodeficiency virus-infected macaques despite efficient reduction of viremia by highly active antiretroviral therapy during primary infection. J Virol. 2001;75:11594-602 pubmed
Castoria G, Migliaccio A, Bilancio A, Di Domenico M, de Falco A, Lombardi M, et al. PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells. EMBO J. 2001;20:6050-9 pubmed
Fukumoto T, Watanabe Fukunaga R, Fujisawa K, Nagata S, Fukunaga R. The fused protein kinase regulates Hedgehog-stimulated transcriptional activation in Drosophila Schneider 2 cells. J Biol Chem. 2001;276:38441-8 pubmed
Chavand O, Spilsbury K, Rakoczy P. Addition of a c-myc epitope tag within the VEGF protein does not affect in vitro biological activity. Biochem Cell Biol. 2001;79:107-12 pubmed
Bourgarel Rey V, El Khyari S, Rimet O, Bordas B, Guigal N, Braguer D, et al. Opposite effects of antimicrotubule agents on c-myc oncogene expression depending on the cell lines used. Eur J Cancer. 2000;36:1043-9 pubmed
de Caestecker M, Yahata T, Wang D, Parks W, Huang S, Hill C, et al. The Smad4 activation domain (SAD) is a proline-rich, p300-dependent transcriptional activation domain. J Biol Chem. 2000;275:2115-22 pubmed
Cooper J, Schilling G, Peters M, Herring W, Sharp A, Kaminsky Z, et al. Truncated N-terminal fragments of huntingtin with expanded glutamine repeats form nuclear and cytoplasmic aggregates in cell culture. Hum Mol Genet. 1998;7:783-90 pubmed
product information
Product Type :
Antibody
Product Name :
c-Myc Monoclonal Antibody (9E10.3)
Catalog # :
AHO0062
Quantity :
500 uL
Price :
US 458.00
Clonality :
Monoclonal
Purity :
Protein G
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: Assay-dependent, Immunohistochemistry (Paraffin): 1:25-1:50, Immunomicroscopy: Assay-dependent, Immunoprecipitation: 10 uL, Western Blot: 1:25-1:50
Species :
Human
Clone :
9E10.3
Isotype :
IgG1, kappa
Storage :
4 C
Description :
The c-Myc protein is a 62 kDa transcription factor that is encoded by the c-Myc gene on human chromosome 8q24. c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin dependent kinase, ERK2 and C-Jun N terminal Kinase (JNK) in cell proliferation and cell cycle regulation. Studies have shown that c-Myc is essential for vasculogenesis and angiogenesis in tumor development, which distributes blood throughout the cells. The c-myc oncogene (p62 c-myc) is involved in the control of normal cellular proliferation and differentiation, and the deregulated expression of c-Myc induces apoptosis in different cell types. Antibodies against c-myc epitopes recognize overexpressed proteins containing Myc epitope tag fused to either amino- or carboxy-termini of targeted proteins. c-Myc-, N-Myc- and L-Myc-encoded proteins function in cell proliferation, differentiation and neoplastic disease. Amplification of the c-Myc gene has been found in several types of human tumors including lung, breast and colon carcinomas, while the N-Myc gene has been found amplified in neuroblastomas. Translocation of the c-myc locus on chromosome 8 to the immunoglobulin loci on chromosome 14 (heavy chain); 2 (delta light chain); or 22 (light chain) is described in Burkitts lymphoma and other B-cell lymphoproliferative conditions. An aberrant expression of the c-myc gene occurs in tumors of different origins such as colorectal, gastric, gallbladder, hepatic, mammary, ovarian, endometrial, head and neck, pulmonary, prostatic, thyroidal, oral, ocular, nasopharyngeal, endocrine, as well as hematopoietic neoplasms.
Immunogen :
A synthetic peptide, corresponding to aa 408-439 (AEEQKLISEEDLLRKRREQLKHKLEQLRNSCA) from C-terminus of human c-myc, coupled to KLH.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: Assay-dependent, Immunohistochemistry (Paraffin): 1:25-1:50, Immunomicroscopy: Assay-dependent, Immunoprecipitation: 10 uL, Western Blot: 1:25-1:50
Aliases :
AU016757; Avian myelocytomatosis viral (v-myc) oncogene homolog; avian myelocytomatosis viral oncogene homolog; bHLHe39; c Myc; class E basic helix-loop-helix protein 39; cmyc; c-Myc; c-myc epitope tag; c-myc proto-oncogene; mMyc; MRTL; Myc; Myc protein; Myc proto-oncogene protein; MYC proto-oncogene, bHLH transcription factor; Myc2; MYCC; myc-related translation/localization regulatory factor; myelocytomatosis oncogene; myelocytomatosis viral oncogene homolog; Niard; Nird; Proto-oncogene c-Myc; RNCMYC; Transcription factor p64; v-myc avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene-like protein
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA