SRC (active) Monoclonal Antibody (28) | Invitrogen AHO0051 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

SRC (active) Monoclonal Antibody (28)

catalog :

AHO0051

quantity :

50 µg

price :

US 450.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

reactivity :

human, mouse, rat, zebrafish

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 16

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; 1:400; fig f1a western blot; human; 1:1000; fig f2	Mello A, Leal M, Rey J, Pinto G, LamarÃ£o L, Montenegro R, et al. Deregulated Expression of SRC, LYN and CKB Kinases by DNA Methylation and Its Potential Role in Gastric Cancer Invasiveness and Metastasis. PLoS ONE. 2015;10:e0140492 pubmed publisher
western blot; mouse	McGinnis L, Pelech S, Kinsey W. Post-ovulatory aging of oocytes disrupts kinase signaling pathways and lysosome biogenesis. Mol Reprod Dev. 2014;81:928-45 pubmed publisher
western blot; human; fig 5	Lee Y, Chung S, Baek I, Lee T, Paik S, Lee J. UNC119a bridges the transmission of Fyn signals to Rab11, leading to the completion of cytokinesis. Cell Cycle. 2013;12:1303-15 pubmed publisher
western blot; mouse; 1:50,000; fig 3	Tremper Wells B, Resnick R, Zheng X, Holsinger L, Shalloway D. Extracellular domain dependence of PTPalpha transforming activity. Genes Cells. 2010;15:711-724 pubmed publisher
western blot; human	Hu X, Dang Y, Tenney K, Crews P, Tsai C, Sixt K, et al. Regulation of c-Src nonreceptor tyrosine kinase activity by bengamide A through inhibition of methionine aminopeptidases. Chem Biol. 2007;14:764-74 pubmed
immunohistochemistry - frozen section; zebrafish ; 2.5 ug/ml	Sharma D, Kinsey W. Fertilization triggers localized activation of Src-family protein kinases in the zebrafish egg. Dev Biol. 2006;295:604-14 pubmed
	Karim N, Ullah A, Wang H, Shoukier M, Pulliam S, Khaled A, et al. A Phase I Study of the Non-Receptor Kinase Inhibitor Bosutinib in Combination with Pemetrexed in Patients with Selected Metastatic Solid Tumors. Curr Oncol. 2022;29:9461-9473 pubmed publisher
	Shabangu C, Siphepho P, Li C, Cheng W, Lu M, Huang C, et al. The Persistence of Hepatitis C Virus Infection in Hepatocytes Promotes Hepatocellular Carcinoma Progression by Pro-Inflammatory Interluekin-8 Expression. Biomedicines. 2021;9: pubmed publisher
	Mir C, Garcia Mayea Y, Garcia L, Herrero P, Canela N, Tabernero R, et al. SDCBP Modulates Stemness and Chemoresistance in Head and Neck Squamous Cell Carcinoma through Src Activation. Cancers (Basel). 2021;13: pubmed publisher
	Garcia Mayea Y, Mir C, Carballo L, Castellvi J, Temprana Salvador J, Lorente J, et al. TSPAN1: A Novel Protein Involved in Head and Neck Squamous Cell Carcinoma Chemoresistance. Cancers (Basel). 2020;12: pubmed publisher
	Grafinger O, Gorshtein G, Stirling T, Brasher M, Coppolino M. β1 integrin-mediated signaling regulates MT1-MMP phosphorylation to promote tumor cell invasion. J Cell Sci. 2020;133: pubmed publisher
	Hermida Prado F, Granda Díaz R, Del Río Ibisate N, Villaronga M, Allonca E, Garmendia I, et al. The Differential Impact of SRC Expression on the Prognosis of Patients with Head and Neck Squamous Cell Carcinoma. Cancers (Basel). 2019;11: pubmed publisher
	Li Y, Jiang G, Chen L, Jiang Y, Jiao J. Formin mDia1 contributes to migration and epithelial-mesenchymal transition of tubular epithelial cells exposed to TGF-β1. J Cell Biochem. 2020;121:3861-3870 pubmed publisher
	Roycroft A, Szabo A, Bahm I, Daly L, Charras G, Parsons M, et al. Redistribution of Adhesive Forces through Src/FAK Drives Contact Inhibition of Locomotion in Neural Crest. Dev Cell. 2018;45:565-579.e3 pubmed publisher
	Bernard Trifilo J, Lim S, Hou S, Schlaepfer D, Ilic D. Analyzing FAK and Pyk2 in early integrin signaling events. Curr Protoc Cell Biol. 2006;Chapter 14:Unit 14.7 pubmed publisher
	Shimizu A, Maruyama T, Tamaki K, Uchida H, Asada H, Yoshimura Y. Impairment of decidualization in SRC-deficient mice. Biol Reprod. 2005;73:1219-27 pubmed

product information

Product Type :

Antibody

Product Name :

SRC (active) Monoclonal Antibody (28)

Catalog # :

AHO0051

Quantity :

50 µg

Price :

US 450.00

Clonality :

Monoclonal

Purity :

purified

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

Immunohistochemistry: Assay-dependent, Western Blot: 1.0 µg/mL

Species :

Human, Mouse, Rat

Clone :

Isotype :

IgG2a, kappa

Storage :

-20°C

Description :

SRC is a cytoplasmic tyrosine kinase and proto-oncogene involved in the regulation of embryonic development and cell growth. SRC is involved in the regulation of growth and differentiation of eukaryotic cells. SRC associates with the cytoplasmic region of various cell surface receptors to facilitate signal transduction, and is also involved in cytoskeletal organization, cell cycle regulation, and apoptosis. In humans, the gene encoding SRC is present on chromosome 20. Activity of SRC is regulated by two tyrosine residues (Tyr 416 and Tyr527), and phosphorylation of these two sites have opposing effects. Phosphorylation of Tyr416 in the activation loop of the kinase domain upregulates enzyme activity while the phosphorylation of Tyr527 decreases enzyme activity. Mutations in the SRC gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same SRC protein have been found thus far.

Immunogen :

KLH conjugated peptide corresponding to amino acid residues 519-536 of human c-Src.

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry: Assay-dependent, Western Blot: 1.0 µg/mL

Aliases :

ASV; AW259666; csrc; c-SRC; c-src protein, C terminus; EC 2.7.10.2; fc54g04; Neuronal proto-oncogene tyrosine-protein kinase Src; non-tyrosine protein kinase; ORF; OTTHUMP00000174476; OTTHUMP00000174477; OTTHUMP00000174478; p60-Src; p60-Src-1; PP60C-SCR; pp60c-src; pp60src; pp60v-src; protein-tyrosine kinase; proto-oncogene c-Src; protooncogene SRC, Rous sarcoma; Proto-oncogene tyrosine-protein kinase Src; Rous sarcoma oncogene; RP5-823N20.1; sb:cb864; SDR; src; src downstream region; src oncogene; SRC proto-oncogene, non-receptor tyrosine kinase; SRC proto-oncogene, non-receptor tyrosine kinase L homeolog; SRC proto-oncogene, non-receptor tyrosine kinase S homeolog; src.L; src.S; SRC1; src-1; src1-A; src-a; src-b; THC6; transforming protein; tyrosine kinase pp60c-src; tyrosine protein kinase c-src; tyrosine protein kinase pp60-c-src; tyrosine-protein kinase SRC-1; Unknown; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog; v-src sarcoma viral oncogene; wu:fc54g04; XELAEV_18046582mg; xsrc

more info or order :

Invitrogen product webpage