IL-10 Monoclonal Antibody (945A5D11) | Invitrogen AHC8102 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IL-10 Monoclonal Antibody (945A5D11)

catalog :

AHC8102

quantity :

500 µg

price :

US 446.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

945A5D11

reactivity :

South American squirrel monkey, baboon , African green monkey, human, rhesus macaque

application :

ELISA, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 10

Published Application/Species/Sample/Dilution	Reference
ELISA; South American squirrel monkey	Riccio E, Pratt Riccio L, Bianco JÃºnior C, Sanchez V, Totino P, Carvalho L, et al. Molecular and immunological tools for the evaluation of the cellular immune response in the neotropical monkey Saimiri sciureus, a non-human primate model for malaria research. Malar J. 2015;14:166 pubmed publisher
immunohistochemistry - paraffin section; human; 1:200	Freysdottir J, Zhang S, Tilakaratne W, Fortune F. Oral biopsies from patients with orofacial granulomatosis with histology resembling Crohn's disease have a prominent Th1 environment. Inflamm Bowel Dis. 2007;13:439-45 pubmed
ELISA; human; 1 ug/ml	Njemini R, Lambert M, Demanet C, Mets T. The effect of aging and inflammation on heat shock protein 27 in human monocytes and lymphocytes. Exp Gerontol. 2006;41:312-9 pubmed
ELISA; human; 1 ug/ml; tbl 1	Kooijman R, Coppens A. Insulin-like growth factor-I stimulates IL-10 production in human T cells. J Leukoc Biol. 2004;76:862-7 pubmed
ELISA; human; fig 6	Thoma Uszynski S, Kiertscher S, Ochoa M, Bouis D, Norgard M, Miyake K, et al. Activation of toll-like receptor 2 on human dendritic cells triggers induction of IL-12, but not IL-10. J Immunol. 2000;165:3804-10 pubmed
ELISA; African green monkey; 3 ug/ml; fig 2	Farah I, Mola P, Kariuki T, Nyindo M, Blanton R, King C. Repeated exposure induces periportal fibrosis in Schistosoma mansoni-infected baboons: role of TGF-beta and IL-4. J Immunol. 2000;164:5337-43 pubmed
ELISA; human	Braun M, Lahey E, Kelsall B. Selective suppression of IL-12 production by chemoattractants. J Immunol. 2000;164:3009-17 pubmed
ELISA; baboon ; 3 ug/ml	Mola P, Farah I, Kariuki T, Nyindo M, Blanton R, King C. Cytokine control of the granulomatous response in Schistosoma mansoni-infected baboons: role of exposure and treatment. Infect Immun. 1999;67:6565-71 pubmed
ELISA; rhesus macaque; fig 5	Kenney R, Sacks D, Sypek J, Vilela L, Gam A, Evans Davis K. Protective immunity using recombinant human IL-12 and alum as adjuvants in a primate model of cutaneous leishmaniasis. J Immunol. 1999;163:4481-8 pubmed
ELISA; human	Braun M, He J, Wu C, Kelsall B. Cholera toxin suppresses interleukin (IL)-12 production and IL-12 receptor beta1 and beta2 chain expression. J Exp Med. 1999;189:541-52 pubmed

product information

Product Type :

Antibody

Product Name :

IL-10 Monoclonal Antibody (945A5D11)

Catalog # :

AHC8102

Quantity :

500 µg

Price :

US 446.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

ELISA: Assay-dependent

Species :

Human

Clone :

945A5D11

Isotype :

IgG1, kappa

Storage :

4° C

Description :

IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes. This cytokine has various effects on immunoregulation and inflammation, including down-regulating the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. Additionally, IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice have suggested that this cytokine is an essential immunoregulator in the intestinal tract. Mutations in this gene have been associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.

Immunogen :

Recombinant human IL-10.

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent

Aliases :

CSIF; cytokine; Cytokine synthesis inhibitory factor; GVHDS; H-IL-10; il 10; IL10; IL-10; IL-10 precursor; IL10A; IL10X; ILN; Interleukin; interleukin 10; Interleukin10; interleukin-10; MGC126450; MGC126451; RP11-262N9.1; T-cell growth inhibitory factor; TGIF

more info or order :

Invitrogen product webpage