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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
IFN gamma Monoclonal Antibody (67F12A8), Biotin
catalog :
AHC4539
quantity :
100 ug
price :
US 474.00
clonality :
monoclonal
host :
mouse
conjugate :
biotin
clone name :
67F12A8
reactivity :
human, chimpanzee
application :
ELISA, other
more info or order :
Invitrogen product webpage
citations: 14
Published Application/Species/Sample/DilutionReference
  • other; human; tbl 1
Wu F, Wang L, Guo Q, Zhao M, Gu H, Xu H, et al. A Homogeneous Immunoassay Method for Detecting Interferon-Gamma in Patients with Latent Tuberculosis Infection. J Microbiol Biotechnol. 2016;26:588-95 pubmed publisher
  • ELISA; chimpanzee; fig 3
Daubersies P, Ollomo B, Sauzet J, Brahimi K, Perlaza B, Eling W, et al. Genetic immunisation by liver stage antigen 3 protects chimpanzees against malaria despite low immune responses. PLoS ONE. 2008;3:e2659 pubmed publisher
  • ELISA; human; fig 3
Takeda K, Suzuki T, Shimada S, Shida K, Nanno M, Okumura K. Interleukin-12 is involved in the enhancement of human natural killer cell activity by Lactobacillus casei Shirota. Clin Exp Immunol. 2006;146:109-15 pubmed
  • ELISA; human
Gorski K, Waller E, Bjornton Severson J, Hanten J, Riter C, Kieper W, et al. Distinct indirect pathways govern human NK-cell activation by TLR-7 and TLR-8 agonists. Int Immunol. 2006;18:1115-26 pubmed
  • ELISA; human; 1:1000
Njemini R, Lambert M, Demanet C, Mets T. The effect of aging and inflammation on heat shock protein 27 in human monocytes and lymphocytes. Exp Gerontol. 2006;41:312-9 pubmed
  • ELISA; human
Haddeland U, Sletten G, Brandtzaeg P, Nakstad B. Impaired interleukin (IL)-4-associated generation of CCR4-expressing T cells in neonates with hereditary allergy risk. Clin Exp Immunol. 2005;139:314-22 pubmed
  • ELISA; human
Temmerman S, Pethe K, Parra M, Alonso S, Rouanet C, Pickett T, et al. Methylation-dependent T cell immunity to Mycobacterium tuberculosis heparin-binding hemagglutinin. Nat Med. 2004;10:935-41 pubmed
  • ELISA; human
Singh S, Soe S, Mejia J, Roussilhon C, Theisen M, Corradin G, et al. Identification of a conserved region of Plasmodium falciparum MSP3 targeted by biologically active antibodies to improve vaccine design. J Infect Dis. 2004;190:1010-8 pubmed
  • ELISA; human; 0.2 ug/ml; tbl 1
Kooijman R, Coppens A. Insulin-like growth factor-I stimulates IL-10 production in human T cells. J Leukoc Biol. 2004;76:862-7 pubmed
  • ELISA; human; 0.5 ug/ml; fig 1
Stewart S, Vidali M, Day C, Albano E, Jones D. Oxidative stress as a trigger for cellular immune responses in patients with alcoholic liver disease. Hepatology. 2004;39:197-203 pubmed
  • ELISA; human; fig 4
Mascart F, Verscheure V, Malfroot A, Hainaut M, Pierard D, Temerman S, et al. Bordetella pertussis infection in 2-month-old infants promotes type 1 T cell responses. J Immunol. 2003;170:1504-9 pubmed
  • ELISA; human; fig 2, 3
Bullens D, Rafiq K, Charitidou L, Peng X, Kasran A, Warmerdam P, et al. Effects of co-stimulation by CD58 on human T cell cytokine production: a selective cytokine pattern with induction of high IL-10 production. Int Immunol. 2001;13:181-91 pubmed
  • ELISA; human
Braun M, He J, Wu C, Kelsall B. Cholera toxin suppresses interleukin (IL)-12 production and IL-12 receptor beta1 and beta2 chain expression. J Exp Med. 1999;189:541-52 pubmed
Gordón Alonso M, Hirsch T, Wildmann C, van der Bruggen P. Galectin-3 captures interferon-gamma in the tumor matrix reducing chemokine gradient production and T-cell tumor infiltration. Nat Commun. 2017;8:793 pubmed publisher
product information
Product Type :
Antibody
Product Name :
IFN gamma Monoclonal Antibody (67F12A8), Biotin
Catalog # :
AHC4539
Quantity :
100 ug
Price :
US 474.00
Clonality :
Monoclonal
Purity :
protein A
Host :
Mouse
Reactivity :
Human
Applications :
ELISA: Assay-dependent
Species :
Human
Clone :
67F12A8
Isotype :
IgG1, kappa
Storage :
4 C
Description :
IFN gamma (Interferon gamma, Type II interferon) is a macrophage activation factor, and immune interferon that is produced primarily by T-lymphocytes and natural killer cells in response to antigens, mitogens, Staphylococcus enterotoxin B, phytohemaglutanin and other cytokines. IFN gamma is a dimeric protein consisting of two 146 amino acid subunits. IFN gamma is a glycoprotein that exists, functionally, as a homodimer of approximately 45 kDa. On SDS-PAGE, IFN gamma appears as a combination of 25, 20 and minor 15.5 kDa bands as a result of differential glycosylation. The biological activity of the IFN gamma homodimer is highly species specific. Human IFN gamma does not show cross-reactivity with mouse. IFN gamma function includes the following: antiviral activity, tumor antiproliferative activity, induction of class I and II MHC, macrophage activation, and enhanced immunoglobulin secretion by B lymphocytes. IFN gamma is involved in cytokine regulation and also acts synergistically with other cytokines. Activation of IFN gamma takes place through binding of IFN gamma receptor I and II, and activating the JAK-STAT pathway. IFN gamma does not show any homology with IFN alpha or IFN beta but human IFN gamma shows about 40% sequence homology with mouse IFN gamma. IFN gamma is upregulated by IL2, FGF basic, EGF and downregulated by vitamin D3 or DMN. IFN gamma gene mutations are associated with aplastic anemia.
Immunogen :
Recombinant human interferon-gamma.
Format :
Liquid
Applications w/Dilutions :
ELISA: Assay-dependent
Aliases :
BoIFNG; cytokine; EGK_03901; gamma interferon; gamma interferon precursor; gamma-interferon; gamma-interferon precursor (AA -23 to 143); H-IFN-g; IFG; IFI; IFN gamma; IFN ?; Ifng; IFN-g; IFNG2; IFN-gamma; IFN-gamma precursor; IFN-y; IFN?; Immune interferon; Interferon; interferon gamma; interferon gamma precursor; interferon gamma type 2; Interferon y; Interferon ?; interferon, gamma; interferon-gama; interferon-gamma; Interferon-gamma level; interferon-gamma precursor; Interferon?; M-IFN-g; R-IFN-g
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA