IFN gamma Monoclonal Antibody (350B 10G6) | Invitrogen AHC4432 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IFN gamma Monoclonal Antibody (350B 10G6)

catalog :

AHC4432

quantity :

500 µg

price :

US 446.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

350B 10G6

reactivity :

human, chimpanzee

application :

ELISA, immunohistochemistry - frozen section, blocking or activating experiments, other

more info or order :

Invitrogen product webpage

citations: 20

Published Application/Species/Sample/Dilution	Reference
other; human; tbl 1	Wu F, Wang L, Guo Q, Zhao M, Gu H, Xu H, et al. A Homogeneous Immunoassay Method for Detecting Interferon-Gamma in Patients with Latent Tuberculosis Infection. J Microbiol Biotechnol. 2016;26:588-95 pubmed publisher
blocking or activating experiments; human; 5 ug/ml	Chen M, Tsai T, Lin Y, Tsai Y, Wang L, Lee M, et al. Antipsychotic drugs suppress the AKT/NF-?B pathway and regulate the differentiation of T-cell subsets. Immunol Lett. 2011;140:81-91 pubmed publisher
ELISA; chimpanzee; fig 3	Daubersies P, Ollomo B, Sauzet J, Brahimi K, Perlaza B, Eling W, et al. Genetic immunisation by liver stage antigen 3 protects chimpanzees against malaria despite low immune responses. PLoS ONE. 2008;3:e2659 pubmed publisher
ELISA; human; fig 3	Takeda K, Suzuki T, Shimada S, Shida K, Nanno M, Okumura K. Interleukin-12 is involved in the enhancement of human natural killer cell activity by Lactobacillus casei Shirota. Clin Exp Immunol. 2006;146:109-15 pubmed
ELISA; human; 1.6 ug/ml	Njemini R, Lambert M, Demanet C, Mets T. The effect of aging and inflammation on heat shock protein 27 in human monocytes and lymphocytes. Exp Gerontol. 2006;41:312-9 pubmed
ELISA; human	Haddeland U, Sletten G, Brandtzaeg P, Nakstad B. Impaired interleukin (IL)-4-associated generation of CCR4-expressing T cells in neonates with hereditary allergy risk. Clin Exp Immunol. 2005;139:314-22 pubmed
ELISA; human	Temmerman S, Pethe K, Parra M, Alonso S, Rouanet C, Pickett T, et al. Methylation-dependent T cell immunity to Mycobacterium tuberculosis heparin-binding hemagglutinin. Nat Med. 2004;10:935-41 pubmed
ELISA; human	Singh S, Soe S, Mejia J, Roussilhon C, Theisen M, Corradin G, et al. Identification of a conserved region of Plasmodium falciparum MSP3 targeted by biologically active antibodies to improve vaccine design. J Infect Dis. 2004;190:1010-8 pubmed
ELISA; human; 1 ug/ml; tbl 1	Kooijman R, Coppens A. Insulin-like growth factor-I stimulates IL-10 production in human T cells. J Leukoc Biol. 2004;76:862-7 pubmed
ELISA; human; 2.5 ug/ml; fig 1	Stewart S, Vidali M, Day C, Albano E, Jones D. Oxidative stress as a trigger for cellular immune responses in patients with alcoholic liver disease. Hepatology. 2004;39:197-203 pubmed
ELISA; human; fig 1	Listvanova S, Temmerman S, Stordeur P, Verscheure V, Place S, Zhou L, et al. Optimal kinetics for quantification of antigen-induced cytokines in human peripheral blood mononuclear cells by real-time PCR and by ELISA. J Immunol Methods. 2003;281:27-35 pubmed
ELISA; human; fig 4	Mascart F, Verscheure V, Malfroot A, Hainaut M, Pierard D, Temerman S, et al. Bordetella pertussis infection in 2-month-old infants promotes type 1 T cell responses. J Immunol. 2003;170:1504-9 pubmed
ELISA; human; fig 2, 3	Bullens D, Rafiq K, Charitidou L, Peng X, Kasran A, Warmerdam P, et al. Effects of co-stimulation by CD58 on human T cell cytokine production: a selective cytokine pattern with induction of high IL-10 production. Int Immunol. 2001;13:181-91 pubmed
immunohistochemistry - frozen section; human; tbl 3	Ribeiro U, Whiteside T, Basse P, Safatle Ribeiro A, Huneke C, Posner M. Activated natural killer cell tumor retention and cytokine production in colon tumor using a tissue-isolated model. J Surg Res. 1999;82:78-87 pubmed
ELISA; human	Braun M, He J, Wu C, Kelsall B. Cholera toxin suppresses interleukin (IL)-12 production and IL-12 receptor beta1 and beta2 chain expression. J Exp Med. 1999;189:541-52 pubmed
	Gordón Alonso M, Hirsch T, Wildmann C, van der Bruggen P. Galectin-3 captures interferon-gamma in the tumor matrix reducing chemokine gradient production and T-cell tumor infiltration. Nat Commun. 2017;8:793 pubmed publisher
	Arlen P, Gulley J, Palena C, Marshall J, Schlom J, Tsang K. A novel ELISPOT assay to enhance detection of antigen-specific T cells employing antigen-presenting cells expressing vector-driven human B7-1. J Immunol Methods. 2003;279:183-92 pubmed
	Messmann R, Ullmann C, Lahusen T, Kalehua A, Wasfy J, Melillo G, et al. Flavopiridol-related proinflammatory syndrome is associated with induction of interleukin-6. Clin Cancer Res. 2003;9:562-70 pubmed
	Kesavalu L, Falk C, Davis K, Steffen M, Xu X, Holt S, et al. Biological characterization of lipopolysaccharide from Treponema pectinovorum. Infect Immun. 2002;70:211-7 pubmed
	Nixon C, Steffen M, Ebersole J. Cytokine responses to treponema pectinovorum and treponema denticola in human gingival fibroblasts. Infect Immun. 2000;68:5284-92 pubmed

product information

Product Type :

Antibody

Product Name :

IFN gamma Monoclonal Antibody (350B 10G6)

Catalog # :

AHC4432

Quantity :

500 µg

Price :

US 446.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

ELISA: Assay-dependent

Species :

Human

Clone :

350B 10G6

Isotype :

IgG1, kappa

Storage :

4° C

Description :

IFN gamma (Interferon gamma, Type II interferon) is a macrophage activation factor, and immune interferon that is produced primarily by T-lymphocytes and natural killer cells in response to antigens, mitogens, Staphylococcus enterotoxin B, phytohemaglutanin and other cytokines. IFN gamma is a dimeric protein consisting of two 146 amino acid subunits. IFN gamma is a glycoprotein that exists, functionally, as a homodimer of approximately 45 kDa. On SDS-PAGE, IFN gamma appears as a combination of 25, 20 and minor 15.5 kDa bands as a result of differential glycosylation. The biological activity of the IFN gamma homodimer is highly species specific. Human IFN gamma does not show cross-reactivity with mouse. IFN gamma function includes the following: antiviral activity, tumor antiproliferative activity, induction of class I and II MHC, macrophage activation, and enhanced immunoglobulin secretion by B lymphocytes. IFN gamma is involved in cytokine regulation and also acts synergistically with other cytokines. Activation of IFN gamma takes place through binding of IFN gamma receptor I and II, and activating the JAK-STAT pathway. IFN gamma does not show any homology with IFN alpha or IFN beta but human IFN gamma shows about 40% sequence homology with mouse IFN gamma. IFN gamma is upregulated by IL2, FGF basic, EGF and downregulated by vitamin D3 or DMN. IFN gamma gene mutations are associated with aplastic anemia.

Immunogen :

Purified recombinant human interferon-gamma (IFN-gamma).

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent

Aliases :

BoIFNG; cytokine; EGK_03901; gamma interferon; gamma interferon precursor; gamma-interferon; gamma-interferon precursor (AA -23 to 143); H-IFN-g; IFG; IFI; IFN gamma; IFN ?; Ifng; IFN-g; IFNG2; IFN-gamma; IFN-gamma precursor; IFN-y; IFN?; Immune interferon; interferon gamma; interferon gamma precursor; interferon gamma type 2; Interferon y; Interferon ?; interferon, gamma; interferon-gama; interferon-gamma; Interferon-gamma level; interferon-gamma precursor; Interferon?; M-IFN-g; R-IFN-g

more info or order :

Invitrogen product webpage