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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
TNF alpha Monoclonal Antibody (68B2B3)
catalog :
AHC3912
quantity :
500 µg
price :
US 446.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
68B2B3
reactivity :
human
application :
ELISA, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 13
| Published Application/Species/Sample/Dilution | Reference |
|---|---|
| Freysdottir J, Zhang S, Tilakaratne W, Fortune F. Oral biopsies from patients with orofacial granulomatosis with histology resembling Crohn's disease have a prominent Th1 environment. Inflamm Bowel Dis. 2007;13:439-45 pubmed
|
| Janke M, Witsch E, Mages H, Hutloff A, Kroczek R. Eminent role of ICOS costimulation for T cells interacting with plasmacytoid dendritic cells. Immunology. 2006;118:353-60 pubmed
|
| Njemini R, Lambert M, Demanet C, Mets T. The effect of aging and inflammation on heat shock protein 27 in human monocytes and lymphocytes. Exp Gerontol. 2006;41:312-9 pubmed
|
| Shen C, Maerten P, Geboes K, Van Assche G, Rutgeerts P, Ceuppens J. Infliximab induces apoptosis of monocytes and T lymphocytes in a human-mouse chimeric model. Clin Immunol. 2005;115:250-9 pubmed
|
| Shen C, Assche G, Colpaert S, Maerten P, Geboes K, Rutgeerts P, et al. Adalimumab induces apoptosis of human monocytes: a comparative study with infliximab and etanercept. Aliment Pharmacol Ther. 2005;21:251-8 pubmed
|
| Arredouani M, Kasran A, Vanoirbeek J, Berger F, Baumann H, Ceuppens J. Haptoglobin dampens endotoxin-induced inflammatory effects both in vitro and in vivo. Immunology. 2005;114:263-71 pubmed
|
| Vinogradov E, Paul C, Li J, Zhou Y, Lyle E, Tapping R, et al. The structure and biological characteristics of the Spirochaeta aurantia outer membrane glycolipid LGLB. Eur J Biochem. 2004;271:4685-95 pubmed
|
| Soop M, Duxbury H, Agwunobi A, Gibson J, Hopkins S, Childs C, et al. Euglycemic hyperinsulinemia augments the cytokine and endocrine responses to endotoxin in humans. Am J Physiol Endocrinol Metab. 2002;282:E1276-85 pubmed
|
| Kooijman R, Coppens A, Hooghe Peters E. Igf-I inhibits spontaneous apoptosis in human granulocytes. Endocrinology. 2002;143:1206-12 pubmed
|
| Bullens D, Kasran A, Thielemans K, Bakkus M, Ceuppens J. CD40L-induced IL-12 production is further enhanced by the Th2 cytokines IL-4 and IL-13. Scand J Immunol. 2001;53:455-63 pubmed
|
| Bullens D, Rafiq K, Charitidou L, Peng X, Kasran A, Warmerdam P, et al. Effects of co-stimulation by CD58 on human T cell cytokine production: a selective cytokine pattern with induction of high IL-10 production. Int Immunol. 2001;13:181-91 pubmed
|
| Shields D, Avgeropoulos N, Banik N, Tyor W. Acute multiple sclerosis characterized by extensive mononuclear phagocyte infiltration. Neurochem Res. 2000;25:1517-20 pubmed
|
| Tapping R, Akashi S, Miyake K, Godowski P, Tobias P. Toll-like receptor 4, but not toll-like receptor 2, is a signaling receptor for Escherichia and Salmonella lipopolysaccharides. J Immunol. 2000;165:5780-7 pubmed
|
product information
Product Type :
Antibody
Product Name :
TNF alpha Monoclonal Antibody (68B2B3)
Catalog # :
AHC3912
Quantity :
500 µg
Price :
US 446.00
Clonality :
Monoclonal
Purity :
protein A
Host :
Mouse
Reactivity :
Human
Applications :
ELISA: Assay-dependent
Species :
Human
Clone :
68B2B3
Isotype :
IgG2a
Storage :
4° C
Description :
TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophage and bind to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions. Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis when injected into tumor-bearing mice. Other functions of TNF-alpha include its role in the immune response to bacterial, viral, parasitic and certain fungal infections, as well as its role in the necrosis of specific tumors. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.
Immunogen :
Purified recombinant human TNF-alpha.
Format :
Liquid
Applications w/Dilutions :
ELISA: Assay-dependent
Aliases :
APC1 protein; Cachectin; C-domain 1; C-domain 2; cTNF; DADB-70P7.1; DIF; ICD1; ICD2; Intracellular domain 1; Intracellular domain 2; N-terminal fragment; NTF; RATTNF; Tnf; TNF alpha; TNF superfamily; TNF a; TNF, macrophage-derived; TNF, monocyte-derived; TNFA; TNF-a; TNFalpha; TNF-alpha; Tnfsf1a; TNFSF2; TNFa; TNLG1F; Tumor necrosis factor; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; tumor necrosis factor alpha (cachetin); tumor necrosis factor alpha precursor; tumor necrosis factor ligand 1F; tumor necrosis factor ligand superfamily member 2; Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form; tumor necrosis factor-alpha; tumor necrosis factor-alpha precursor; tumor-necrosis factor; tumour necrosis factor
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com81 Wyman Street
Waltham, MA USA 02451
800-678-5599
headquarters: USA
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