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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
IL-1 alpha Monoclonal Antibody (624B3F2)
catalog :
AHC0912
quantity :
500 µg
price :
US 446.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
624B3F2
reactivity :
human
application :
ELISA, flow cytometry
more info or order :
Invitrogen product webpage
citations: 6
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human
Verdonk P, Wang J, Groeneboer S, Broddelez C, Elewaut D, Veys E, et al. Cyclodextrin polysulphates repress IL-1 and promote the accumulation of chondrocyte extracellular matrix. Osteoarthritis Cartilage. 2005;13:887-95 pubmed
  • flow cytometry; human
Wang J, Elewaut D, Hoffman I, Veys E, Verbruggen G. Physiological levels of hydrocortisone maintain an optimal chondrocyte extracellular matrix metabolism. Ann Rheum Dis. 2004;63:61-6 pubmed
  • flow cytometry; human
Wang J, Verdonk P, Elewaut D, Veys E, Verbruggen G. Homeostasis of the extracellular matrix of normal and osteoarthritic human articular cartilage chondrocytes in vitro. Osteoarthritis Cartilage. 2003;11:801-9 pubmed
  • flow cytometry; human
Wang J, Elewaut D, Veys E, Verbruggen G. Insulin-like growth factor 1-induced interleukin-1 receptor II overrides the activity of interleukin-1 and controls the homeostasis of the extracellular matrix of cartilage. Arthritis Rheum. 2003;48:1281-91 pubmed
Verbruggen G, Wang J, Wang L, Elewaut D, Veys E. Analysis of chondrocyte functional markers and pericellular matrix components by flow cytometry. Methods Mol Med. 2004;100:183-208 pubmed
Nixon C, Steffen M, Ebersole J. Cytokine responses to treponema pectinovorum and treponema denticola in human gingival fibroblasts. Infect Immun. 2000;68:5284-92 pubmed
product information
Product Type :
Antibody
Product Name :
IL-1 alpha Monoclonal Antibody (624B3F2)
Catalog # :
AHC0912
Quantity :
500 µg
Price :
US 446.00
Clonality :
Monoclonal
Purity :
protein A
Host :
Mouse
Reactivity :
Human
Applications :
ELISA: Assay-dependent
Species :
Human
Clone :
624B3F2
Isotype :
IgG1, kappa
Storage :
4° C
Description :
IL-1 alpha (Interleukin-1 alpha) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 alpha is coded by the IL1A gene and signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 beta. IL1A is located on the q arm on chromosome 2 at position 13. IL-1 alpha plays an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses. IL-1 alpha activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 alpha is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. Further, IL-1 alpha is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury and induces apoptosis. The IL1A gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. IL1 alpha regulates the activities of NF-kappaB and mitogen-activated protein kinases. IL-1 alpha can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-1 alpha are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
Immunogen :
Purified recombinant human IL-1-alpha
Format :
Liquid
Applications w/Dilutions :
ELISA: Assay-dependent
Aliases :
CTLA8; hematopoietin-1; IL 1 a; IL 1a; IL1; IL-1 alpha; IL17; IL1A; Il-1a; IL-1alpha; IL1-ALPHA; IL1F1; IL1a; ILN; Interleukin; interleukin 1 alpha; interleukin 1, alpha; interleukin 17; interleukin 1a; interleukin 1-alpha; interleukin 1-alpha (AA 1 - 152); Interleukin1 alpha; interleukin-1 alpha; interleukin-1 alpha precursor; Interleukin-17A; preinterleukin 1 alpha; pre-interleukin-1 alpha; pro-interleukin-1-alpha; RP23-160G19.8
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA