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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
IL-1 beta Antibody Cocktail
catalog :
AHC0612
quantity :
500 µg
price :
US 456.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
508A4A2 and 508A7G8
reactivity :
human
application :
ELISA
more info or order :
Invitrogen product webpage
citations: 3
Published Application/Species/Sample/DilutionReference
  • ELISA; human; fig 6
Olson N, Graves J, Shu G, Ryan E, Clark E. Caspase activity is required for stimulated B lymphocytes to enter the cell cycle. J Immunol. 2003;170:6065-72 pubmed
  • ELISA; human; 1 ug/ml
Kooijman R, Coppens A, Hooghe Peters E. Igf-I inhibits spontaneous apoptosis in human granulocytes. Endocrinology. 2002;143:1206-12 pubmed
Kesavalu L, Falk C, Davis K, Steffen M, Xu X, Holt S, et al. Biological characterization of lipopolysaccharide from Treponema pectinovorum. Infect Immun. 2002;70:211-7 pubmed
product information
Product Type :
Antibody
Product Name :
IL-1 beta Antibody Cocktail
Catalog # :
AHC0612
Quantity :
500 µg
Price :
US 456.00
Clonality :
Cocktail
Purity :
protein A
Host :
Mouse
Reactivity :
Human
Applications :
ELISA: Assay-dependent
Species :
Human
Clone :
508A4A2 and 508A7G8
Isotype :
IgG1, kappa
Storage :
4° C
Description :
Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is secreted alongside caspase-1 via an alternate and incompletely understood mechanism. Although IL-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions. IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha. IL-1 beta activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions IL-1 beta neutralizing antibodies potential therapeutic value.
Immunogen :
Recombinant human IL-1b
Format :
Liquid
Applications w/Dilutions :
ELISA: Assay-dependent
Aliases :
catabolin; cytokine; Hematopoietin 1 (H1); IFN beta inducing factor; il 1b; IL 1ß; IL-1; IL1 B; IL-1 beta; IL-1 precursor; IL1B; IL-1B; IL1B1; IL1beta; IL-1beta; IL1-BETA; IL1F2; IL1ß; ILN; Interleukin; interleukin 1 beta; Interleukin 1 beta precursor; interleukin 1, beta; interleukin 1, beta 1; interleukin 1-beta; interleukin*1*beta; Interleukin1 beta; interleukin-1 beta; interleukin-1 beta precursor; interleukin-1 beta precursor (AA -113 to 153); interleukin-1 beta proprotein; interleukin-1b; interleukin-1beta; interleukin-beta; LAF; lymphocyte proliferation-potentiating factor; Osteoclast activating factor (OAF); preinterleukin 1 beta; Pro interleukin 1 beta; prointerleukin-1 beta; pro-interleukin-1-beta
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA