Tau (Cleaved Asp421, Asp422) Monoclonal Antibody (TauC3) | Invitrogen AHB0061 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Tau (Cleaved Asp421, Asp422) Monoclonal Antibody (TauC3)

catalog :

AHB0061

quantity :

50 µg

price :

US 450.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

TauC3

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 13

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; mouse; loading ...; fig 3d western blot; mouse; 1:200; loading ...; fig 3a	di Meco A, Pratico D. Early-life exposure to high-fat diet influences brain health in aging mice. Aging Cell. 2019;18:e13040 pubmed publisher
western blot; rat; 1:1000; fig 9	CARTAGENA C, Mountney A, Hwang H, Swiercz A, Rammelkamp Z, Boutte A, et al. Subacute Changes in Cleavage Processing of Amyloid Precursor Protein and Tau following Penetrating Traumatic Brain Injury. PLoS ONE. 2016;11:e0158576 pubmed publisher
immunohistochemistry - paraffin section; human; 1:200; fig 3	Nishikawa T, Takahashi T, Nakamori M, Hosomi N, Maruyama H, Miyazaki Y, et al. The identification of raft-derived tau-associated vesicles that are incorporated into immature tangles and paired helical filaments. Neuropathol Appl Neurobiol. 2016;42:639-653 pubmed publisher
western blot; human; 1:500	Saidi L, Polydoro M, Kay K, Sanchez L, Mandelkow E, Hyman B, et al. Carboxy terminus heat shock protein 70 interacting protein reduces tau-associated degenerative changes. J Alzheimers Dis. 2015;44:937-47 pubmed publisher
	Levert S, Pilliod J, Aumont x, Armanville S, Tremblay C, Calon F, et al. Direct and Indirect Effects of Filamin A on Tau Pathology in Neuronal Cells. Mol Neurobiol. 2022;: pubmed publisher
	Pilliod J, G xe9 linas Faucher M, Leclerc N. Unconventional secretion of tau by VAMP8 impacts its intra- and extracellular cleavage. Front Cell Dev Biol. 2022;10:912118 pubmed publisher
	Koh H, Lee S, Lee H, Min J, Iwatsubo T, Teunissen C, et al. Targeting MicroRNA-485-3p Blocks Alzheimer's Disease Progression. Int J Mol Sci. 2021;22: pubmed publisher
	Ajit D, Trzeciakiewicz H, Tseng J, Wander C, Chen Y, Ajit A, et al. A unique tau conformation generated by an acetylation-mimic substitution modulates P301S-dependent tau pathology and hyperphosphorylation. J Biol Chem. 2019;294:16698-16711 pubmed publisher
	Sandusky Beltran L, Kovalenko A, Ma C, Calahatian J, Placides D, Watler M, et al. Spermidine/spermine-N1-acetyltransferase ablation impacts tauopathy-induced polyamine stress response. Alzheimers Res Ther. 2019;11:58 pubmed publisher
	Zhou Y, Shi J, Chu D, Hu W, Guan Z, Gong C, et al. Relevance of Phosphorylation and Truncation of Tau to the Etiopathogenesis of Alzheimer's Disease. Front Aging Neurosci. 2018;10:27 pubmed publisher
	Kim Y, Jeong E, Nah J, Yoo S, Lee W, Kim Y, et al. Pimozide reduces toxic forms of tau in TauC3 mice via 5' adenosine monophosphate-activated protein kinase-mediated autophagy. J Neurochem. 2017;142:734-746 pubmed publisher
	Fujii H, Takahashi T, Mukai T, Tanaka S, Hosomi N, Maruyama H, et al. Modifications of tau protein after cerebral ischemia and reperfusion in rats are similar to those occurring in Alzheimer's disease - Hyperphosphorylation and cleavage of 4- and 3-repeat tau. J Cereb Blood Flow Metab. 2017;37:2441-2457 pubmed publisher
	Sagare A, Bell R, Zhao Z, Ma Q, Winkler E, Ramanathan A, et al. Pericyte loss influences Alzheimer-like neurodegeneration in mice. Nat Commun. 2013;4:2932 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Tau (Cleaved Asp421, Asp422) Monoclonal Antibody (TauC3)

Catalog # :

AHB0061

Quantity :

50 µg

Price :

US 450.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: 1 µg/mL, Immunohistochemistry (Paraffin): 1:10-1:100, Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent

Species :

Human, Mouse, Rat

Clone :

TauC3

Isotype :

IgG1, kappa

Storage :

-20°C

Description :

Tau is a neuronal microtubule-associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerization and stabilize microtubules. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton while the longer isoforms may preferentially play a role in its stabilization. In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer's diseases (AD) brain. Hyper-phosphorylation impairs the microtubule binding function of Tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Numerous serine/threonine kinases phosphorylate Tau, including GSK-3beta, protein kinase A (PKA), cyclindependent kinase 5 (cdk5) and casein kinase II. Hyper-phosphorylated Tau is found in neurofibrillary lesions in a range and other central nervous system disorders such as Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.

Immunogen :

KLH-CSSTGSIDMVD, corresponding to the C terminus of tau truncated at Asp421.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1 µg/mL, Immunohistochemistry (Paraffin): 1:10-1:100, Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent

Aliases :

map tau; microtubules; neurofibrillary tangles

more info or order :

Invitrogen product webpage