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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Oligomer A11 Polyclonal Antibody
catalog :
AHB0052
quantity :
50 µg
price :
US 446.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat, zebrafish
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, neutralization, dot blot, other
more info or order :
citations: 67
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:1000; loading ...; fig 1f
Han X, Wang C, Song L, Wang X, Tang S, Hou T, et al. KIBRA regulates amyloid β metabolism by controlling extracellular vesicles secretion. EBioMedicine. 2022;78:103980 pubmed publisher
  • other; zebrafish
Pakdaman Y, Denker E, Austad E, Norton W, Rolfsnes H, Bindoff L, et al. Chip Protein U-Box Domain Truncation Affects Purkinje Neuron Morphology and Leads to Behavioral Changes in Zebrafish. Front Mol Neurosci. 2021;14:723912 pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig 1q
Vandenabeele M, Veys L, Lemmens S, Hadoux X, Gelders G, Masin L, et al. The AppNL-G-F mouse retina is a site for preclinical Alzheimer's disease diagnosis and research. Acta Neuropathol Commun. 2021;9:6 pubmed publisher
  • immunohistochemistry; mouse; fig 3d
Son G, Yoo S, Kang S, Rasheed A, Jung D, Park H, et al. Region-specific amyloid-β accumulation in the olfactory system influences olfactory sensory neuronal dysfunction in 5xFAD mice. Alzheimers Res Ther. 2021;13:4 pubmed publisher
  • immunocytochemistry; human; 1:500; loading ...; fig s5g
Gasset Rosa F, Lu S, Yu H, Chen C, Melamed Z, Guo L, et al. Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death. Neuron. 2019;102:339-357.e7 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s1b
Tseng J, Xie L, Song S, Xie Y, Allen L, Ajit D, et al. The Deacetylase HDAC6 Mediates Endogenous Neuritic Tau Pathology. Cell Rep. 2017;20:2169-2183 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5b
Yang S, Lee D, Shin J, Lee S, Baek S, Kim J, et al. Nec-1 alleviates cognitive impairment with reduction of Aβ and tau abnormalities in APP/PS1 mice. EMBO Mol Med. 2017;9:61-77 pubmed publisher
  • dot blot; mouse; 1:1000; loading ...; fig 3b
Zha J, Liu X, Zhu J, Liu S, Lu S, Xu P, et al. A scFv antibody targeting common oligomeric epitope has potential for treating several amyloidoses. Sci Rep. 2016;6:36631 pubmed publisher
  • dot blot; mouse; loading ...; fig 5c
Laclair K, Donde A, Ling J, Jeong Y, Chhabra R, Martin L, et al. Depletion of TDP-43 decreases fibril and plaque β-amyloid and exacerbates neurodegeneration in an Alzheimer's mouse model. Acta Neuropathol. 2016;132:859-873 pubmed
  • western blot; human; fig s2
Gu M, Viles J. Methionine oxidation reduces lag-times for amyloid-?(1-40) fiber formation but generates highly fragmented fibers. Biochim Biophys Acta. 2016;1864:1260-1269 pubmed publisher
  • other; human; fig 6
Domínguez M, de Oliveira E, Odena M, Portero M, Pamplona R, Ferrer I. Redox proteomic profiling of neuroketal-adducted proteins in human brain: Regional vulnerability at middle age increases in the elderly. Free Radic Biol Med. 2016;95:1-15 pubmed publisher
  • immunocytochemistry; mouse; fig 2
Kaufmann T, Harrison P, Richardson M, Pinheiro T, Wall M. Intracellular soluble α-synuclein oligomers reduce pyramidal cell excitability. J Physiol. 2016;594:2751-72 pubmed publisher
Rofo F, Metzendorf N, Saubi C, Suominen L, Godec A, Sehlin D, et al. Blood-brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer's disease. Alzheimers Res Ther. 2022;14:180 pubmed publisher
Lee H, Yoon S, Lee J, Park K, Jung Y, Cho I, et al. Aryloxypropanolamine targets amyloid aggregates and reverses Alzheimer-like phenotypes in Alzheimer mouse models. Alzheimers Res Ther. 2022;14:177 pubmed publisher
Jo K, Lee D, Cha D, Oh E, Choi Y, Kim S, et al. Gossypetin ameliorates 5xFAD spatial learning and memory through enhanced phagocytosis against Aβ. Alzheimers Res Ther. 2022;14:158 pubmed publisher
Xu B, He Y, Liu L, Ye G, Chen L, Wang Q, et al. The Effects of Physical Running on Dendritic Spines and Amyloid-beta Pathology in 3xTg-AD Male Mice. Aging Dis. 2022;13:1293-1310 pubmed publisher
Alpaugh M, Masnata M, de Rus Jacquet A, Lepinay E, Denis H, Saint Pierre M, et al. Passive immunization against phosphorylated tau improves features of Huntington's disease pathology. Mol Ther. 2022;30:1500-1522 pubmed publisher
An S, Shim K, Kang S, Kim Y, Subedi L, Cho H, et al. The potential anti-amyloidogenic candidate, SPA1413, for Alzheimer's disease. Br J Pharmacol. 2022;179:1033-1048 pubmed publisher
Balczon R, Lin M, Lee J, Abbasi A, Renema P, Voth S, et al. Pneumonia initiates a tauopathy. FASEB J. 2021;35:e21807 pubmed publisher
Perez Garcia G, De Gasperi R, Tschiffely A, Gama Sosa M, Abutarboush R, Kawoos U, et al. Repetitive Low-Level Blast Exposure Improves Behavioral Deficits and Chronically Lowers Aβ42 in an Alzheimer Disease Transgenic Mouse Model. J Neurotrauma. 2021;38:3146-3173 pubmed publisher
Palanikumar L, Karpauskaite L, Al Sayegh M, Chehade I, Alam M, Hassan S, et al. Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function. Nat Commun. 2021;12:3962 pubmed publisher
Martin T, Myers V, Dubey P, Dubey S, Perez E, Moravec C, et al. Cardiomyocyte contractile impairment in heart failure results from reduced BAG3-mediated sarcomeric protein turnover. Nat Commun. 2021;12:2942 pubmed publisher
Johari M, Sarparanta J, Vihola A, Jonson P, Savarese M, Jokela M, et al. Missense mutations in small muscle protein X-linked (SMPX) cause distal myopathy with protein inclusions. Acta Neuropathol. 2021;142:375-393 pubmed publisher
Narendran S, Pereira F, Yerramothu P, Apicella I, Wang S, Ambati K, et al. Nucleoside reverse transcriptase inhibitors and Kamuvudines inhibit amyloid-β induced retinal pigmented epithelium degeneration. Signal Transduct Target Ther. 2021;6:149 pubmed publisher
Martinez Valbuena I, Valenti Azcarate R, Amat Villegas I, Marcilla I, Martí Andrés G, Caballero M, et al. Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein. Acta Neuropathol Commun. 2021;9:64 pubmed publisher
Cascella R, Chen S, Bigi A, Camino J, Xu C, Dobson C, et al. The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells. Nat Commun. 2021;12:1814 pubmed publisher
Hervás R, Del Carmen Fernández Ramírez M, Galera Prat A, Suzuki M, Nagai Y, Bruix M, et al. Divergent CPEB prion-like domains reveal different assembly mechanisms for a generic amyloid-like fold. BMC Biol. 2021;19:43 pubmed publisher
Varinthra P, Ganesan K, Huang S, Chompoopong S, Eurtivong C, Suresh P, et al. The 4-(Phenylsulfanyl) butan-2-one Improves Impaired Fear Memory Retrieval and Reduces Excessive Inflammatory Response in Triple Transgenic Alzheimer's Disease Mice. Front Aging Neurosci. 2021;13:615079 pubmed publisher
Das R, Chinnathambi S. Microglial remodeling of actin network by Tau oligomers, via G protein-coupled purinergic receptor, P2Y12R-driven chemotaxis. Traffic. 2021;22:153-170 pubmed publisher
Lee D, Park D, Kim I, Lee S, Lee W, Hwang K, et al. Plasmonic nanoparticle amyloid corona for screening Aβ oligomeric aggregate-degrading drugs. Nat Commun. 2021;12:639 pubmed publisher
Romani M, Sorrentino V, Oh C, Li H, de Lima T, Zhang H, et al. NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle. Cell Rep. 2021;34:108660 pubmed publisher
Santamaria G, Brandi E, Vitola P, Grandi F, Ferrara G, Pischiutta F, et al. Intranasal delivery of mesenchymal stem cell secretome repairs the brain of Alzheimer's mice. Cell Death Differ. 2021;28:203-218 pubmed publisher
Snow W, Cadonic C, Cortes Perez C, Adlimoghaddam A, Roy Chowdhury S, Thomson E, et al. Sex-Specific Effects of Chronic Creatine Supplementation on Hippocampal-Mediated Spatial Cognition in the 3xTg Mouse Model of Alzheimer's Disease. Nutrients. 2020;12: pubmed publisher
Tsai Y, Luo J, Liu T, Lu I, Shen M, Chuang C, et al. Capturing Amyloid-β Oligomers by Stirring with Microscaled Iron Oxide Stir Bars into Magnetic Plaques to Reduce Cytotoxicity toward Neuronal Cells. Nanomaterials (Basel). 2020;10: pubmed publisher
Riad A, Lengyel Zhand Z, Zeng C, Weng C, Lee V, Trojanowski J, et al. The Sigma-2 Receptor/TMEM97, PGRMC1, and LDL Receptor Complex Are Responsible for the Cellular Uptake of Aβ42 and Its Protein Aggregates. Mol Neurobiol. 2020;57:3803-3813 pubmed publisher
Abskharon R, Seidler P, Sawaya M, Cascio D, Yang T, Philipp S, et al. Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease. J Biol Chem. 2020;295:10662-10676 pubmed publisher
Price D, Dorandish S, Williams A, Iwaniec B, Stephens A, Marshall K, et al. Humanin Blocks the Aggregation of Amyloid-β Induced by Acetylcholinesterase, an Effect Abolished in the Presence of IGFBP-3. Biochemistry. 2020;59:1981-2002 pubmed publisher
Campos J, Baehr L, Ferreira N, Bozi L, Andres A, Ribeiro M, et al. β2 -adrenoceptor activation improves skeletal muscle autophagy in neurogenic myopathy. FASEB J. 2020;34:5628-5641 pubmed publisher
Dou J, Su P, Xu C, Wen Z, Mao Z, Li W. Targeting Hsc70-based autophagy to eliminate amyloid β oligomers. Biochem Biophys Res Commun. 2020;524:923-928 pubmed publisher
Jin X, Wang M, Shentu J, Huang C, Bai Y, Pan H, et al. Inhibition of acetylcholinesterase activity and β-amyloid oligomer formation by 6-bromotryptamine A, a multi-target anti-Alzheimer's molecule. Oncol Lett. 2020;19:1593-1601 pubmed publisher
Crist xf3 v xe3 o A, Campos F, Je G, Esteves M, Guhathakurta S, Yang L, et al. Characterization of a Parkinson's disease rat model using an upgraded paraquat exposure paradigm. Eur J Neurosci. 2020;52:3242-3255 pubmed publisher
Beckman D, Ott S, Donis Cox K, Janssen W, Bliss Moreau E, Rudebeck P, et al. Oligomeric Aβ in the monkey brain impacts synaptic integrity and induces accelerated cortical aging. Proc Natl Acad Sci U S A. 2019;: pubmed publisher
Nil Z, Herv s R, Gerbich T, Leal P, Yu Z, Saraf A, et al. Amyloid-like Assembly Activates a Phosphatase in the Developing Drosophila Embryo. Cell. 2019;178:1403-1420.e21 pubmed publisher
Zhang J, Chen B, Lu J, Wu Y, Wang S, Yao Z, et al. Brains of rhesus monkeys display Aβ deposits and glial pathology while lacking Aβ dimers and other Alzheimer's pathologies. Aging Cell. 2019;18:e12978 pubmed publisher
Dagan B, Oren O, Banerjee V, Taube R, Papo N. A hyperthermophilic protein G variant engineered via directed evolution prevents the formation of toxic SOD1 oligomers. Proteins. 2019;87:738-747 pubmed publisher
Ho P, Leung C, Liu H, Pang S, Lam C, Xian J, et al. Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA). Autophagy. 2019;:1-24 pubmed publisher
Wang W, Hou T, Jia L, Wu Q, Quan M, Jia J. Toxic amyloid-β oligomers induced self-replication in astrocytes triggering neuronal injury. EBioMedicine. 2019;42:174-187 pubmed publisher
van Diggelen F, Hrle D, Apetri M, Christiansen G, Rammes G, Tepper A, et al. Two conformationally distinct α-synuclein oligomers share common epitopes and the ability to impair long-term potentiation. PLoS ONE. 2019;14:e0213663 pubmed publisher
Zhang P, Fan B, Yang P, Temirov J, Messing J, Kim H, et al. Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology. elife. 2019;8: pubmed publisher
Xia Y, Zhang G, Han C, Ma K, Guo X, Wan F, et al. Microglia as modulators of exosomal alpha-synuclein transmission. Cell Death Dis. 2019;10:174 pubmed publisher
Bonito Oliva A, Schedin Weiss S, Younesi S, Tiiman A, Adura C, Paknejad N, et al. Conformation-specific antibodies against multiple amyloid protofibril species from a single amyloid immunogen. J Cell Mol Med. 2019;23:2103-2114 pubmed publisher
Vasquez V, Mitra J, Perry G, Rao K, Hegde M. An Inducible Alpha-Synuclein Expressing Neuronal Cell Line Model for Parkinson's Disease1. J Alzheimers Dis. 2018;66:453-460 pubmed publisher
Borin M, Saraceno C, Catania M, Lorenzetto E, Pontelli V, Paterlini A, et al. Rac1 activation links tau hyperphosphorylation and Aβ dysmetabolism in Alzheimer's disease. Acta Neuropathol Commun. 2018;6:61 pubmed publisher
Lee D, Lee W, Lim S, Kim Y, Jung H, Das S, et al. A guanidine-appended scyllo-inositol derivative AAD-66 enhances brain delivery and ameliorates Alzheimer's phenotypes. Sci Rep. 2017;7:14125 pubmed publisher
Rodriguez Rodriguez P, Sandebring Matton A, Merino Serrais P, Parrado Fernandez C, Rabano A, Winblad B, et al. Tau hyperphosphorylation induces oligomeric insulin accumulation and insulin resistance in neurons. Brain. 2017;: pubmed publisher
Taguchi Y, Liu J, Ruan J, Pacheco J, Zhang X, Abbasi J, et al. Glucosylsphingosine Promotes α-Synuclein Pathology in Mutant GBA-Associated Parkinson's Disease. J Neurosci. 2017;37:9617-9631 pubmed publisher
Mukherjee A, Morales Scheihing D, Salvadores N, Moreno Gonzalez I, Gonzalez C, Taylor Presse K, et al. Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism. J Exp Med. 2017;214:2591-2610 pubmed publisher
Kovachev P, Banerjee D, Rangel L, Eriksson J, Pedrote M, Martins Dinis M, et al. Distinct modulatory role of RNA in the aggregation of the tumor suppressor protein p53 core domain. J Biol Chem. 2017;292:9345-9357 pubmed publisher
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product information
Product Type :
Antibody
Product Name :
Oligomer A11 Polyclonal Antibody
Catalog # :
AHB0052
Quantity :
50 µg
Price :
US 446.00
Clonality :
Polyclonal
Purity :
purified
Host :
Rabbit
Reactivity :
Human, Mouse, Rat
Applications :
Dot Blot: 0.1-1 µg/mL, ELISA: 0.1-1 µg/mL, Immunohistochemistry: 1-5 µg/mL, Neutralization: Assay-dependent, Western Blot: Assay-dependent
Species :
Human, Mouse, Rat
Isotype :
IgG
Storage :
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Description :
Many degenerative diseases are known to be related to the accumulation of misfolded proteins called, amyloid fibrils. Soluble amyloid oligomers are considered as the principal pathogenic species which play an important role in the formation of amyloid fibrils; therefore, oligomers are involved in the pathogenesis of the many neurodegenerative diseases. This anti-oligomer antibody provides a facile means of assessing the significance of oligomers in disease pathogenesis.
Immunogen :
Synthetic molecular mimic of soluble oligomers.
Format :
Liquid
Applications w/Dilutions :
Dot Blot: 0.1-1 µg/mL, ELISA: 0.1-1 µg/mL, Immunohistochemistry: 1-5 µg/mL, Neutralization: Assay-dependent, Western Blot: Assay-dependent
Aliases :
Antioligomer A11; IDDM; IDDM1; IDDM2; ILPR; INS; Ins1; Ins-1; Ins2-rs1; Insulin; insulin 1; Insulin A chain; Insulin B chain; insulin I; insulin-1; Insulin-1 A chain; Insulin-1 B chain; IRDN; MODY10; preproinsulin; proinsulin
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA