Mouse TNF-alpha, Animal-Free Recombinant Protein, PeproTech | Invitrogen AF-315-01A-1MG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

protein

product name :

Mouse TNF-alpha, Animal-Free Recombinant Protein, PeproTech

catalog :

AF-315-01A-1MG

quantity :

1 mg

price :

US 3840.00

citations: 13

Reference
Linnerbauer M, L xf6 xdf lein L, Vandrey O, Peter A, Han Y, Tsaktanis T, et al. The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology. Nat Immunol. 2024;25:432-447 pubmed publisher
Linnerbauer M, Beyer T, Nirschl L, Farrenkopf D, L xf6 xdf lein L, Vandrey O, et al. PD-L1 positive astrocytes attenuate inflammatory functions of PD-1 positive microglia in models of autoimmune neuroinflammation. Nat Commun. 2023;14:5555 pubmed publisher
Liang P, Zhou S, Yuan Z, Zhang L, Jiang Z, Yu Q. Obeticholic acid improved triptolide/lipopolysaccharide-induced hepatotoxicity by inhibiting caspase-11-GSDMD pyroptosis pathway. J Appl Toxicol. 2023;43:599-614 pubmed publisher
Zhang R, Xue T, Shao A, Lang Y, Qin C, Zhao M, et al. Bclaf1 regulates c-FLIP expression and protects cells from TNF-induced apoptosis and tissue injury. EMBO Rep. 2022;23:e52702 pubmed publisher
Zhou Y, Cheng Y, Li Y, Ma J, Wu Z, Chen Y, et al. Soluble β-amyloid impaired the GABA inhibition by mediating KCC2 in early APP/PS1 mice. Biosci Trends. 2021;15:330-340 pubmed publisher
Xie C, Ye F, Zhang N, Huang Y, Pan Y, Xie X. CCL7 contributes to angiotensin II-induced abdominal aortic aneurysm by promoting macrophage infiltration and pro-inflammatory phenotype. J Cell Mol Med. 2021;25:7280-7293 pubmed publisher
Zhang L, Zhang Y, Zhou M, Wang S, Li T, Hu Z, et al. Role and mechanism underlying FoxO6 in skeletal muscle in vitro and in vivo. Int J Mol Med. 2021;48: pubmed publisher
Che J, Xu C, Wu Y, Jia P, Han Q, Ma Y, et al. MiR-1290 promotes myoblast differentiation and protects against myotube atrophy via Akt/p70/FoxO3 pathway regulation. Skelet Muscle. 2021;11:6 pubmed publisher
Sonner J, Keil M, Falk Paulsen M, Mishra N, Rehman A, Kramer M, et al. Dietary tryptophan links encephalogenicity of autoreactive T cells with gut microbial ecology. Nat Commun. 2019;10:4877 pubmed publisher
Zhou Z, Lu C, Meng S, Dun L, Yin N, An H, et al. Silencing of PTGS2 exerts promoting effects on angiogenesis endothelial progenitor cells in mice with ischemic stroke via repression of the NF-κB signaling pathway. J Cell Physiol. 2019;234:23448-23460 pubmed publisher
Mandal P, Feng Y, Lyons J, Berger S, Otani S, DeLaney A, et al. Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock. Immunity. 2018;49:42-55.e6 pubmed publisher
Pepin M, Mezouar S, Pegon J, Muczynski V, Adam F, Bianchini E, et al. Soluble Siglec-5 associates to PSGL-1 and displays anti-inflammatory activity. Sci Rep. 2016;6:37953 pubmed publisher
Dai Z, Xing L, Cerise J, Wang E, Jabbari A, de Jong A, et al. CXCR3 Blockade Inhibits T Cell Migration into the Skin and Prevents Development of Alopecia Areata. J Immunol. 2016;197:1089-99 pubmed publisher

product information

Product Type :

Protein

Product Name :

Mouse TNF-alpha, Animal-Free Recombinant Protein, PeproTech

Catalog # :

AF-315-01A-1MG

Quantity :

1 mg

Price :

US 3840.00

Clonality :

Recombinant

Purity :

purified

Reactivity :

Mouse

Applications :

Functional Assay: Assay-dependent

Species :

Mouse

Storage :

-20 C

Description :

TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophage and bind to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions. Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis when injected into tumor-bearing mice. Other functions of TNF-alpha include its role in the immune response to bacterial, viral, parasitic and certain fungal infections, as well as its role in the necrosis of specific tumors. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.

Format :

Lyophilized

Applications w/Dilutions :

Functional Assay: Assay-dependent

Aliases :

APC1 protein; Cachectin; C-domain 1; C-domain 2; cTNF; DADB-70P7.1; DIF; ICD1; ICD2; Intracellular domain 1; Intracellular domain 2; N-terminal fragment; NTF; RATTNF; Tnf; TNF alpha; TNF superfamily; TNF a; TNF, macrophage-derived; TNF, monocyte-derived; TNFA; TNF-a; TNFalpha; TNF-alpha; Tnfsf1a; TNFSF2; TNFa; TNLG1F; Tumor necrosis factor; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; tumor necrosis factor alpha (cachetin); tumor necrosis factor alpha precursor; tumor necrosis factor ligand 1F; tumor necrosis factor ligand superfamily member 2; Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form; tumor necrosis factor-alpha; tumor necrosis factor-alpha precursor; tumor-necrosis factor; tumour necrosis factor