This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
protein
product name :
Human TPO (Thrombopoietin), Animal-Free Recombinant Protein, PeproTech
catalog :
AF-300-18-250UG
quantity :
250 ug
price :
US 1902.00
citations: 56
Reference
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Ho Y, del Toro R, Rivera Torres J, Rak J, Korn C, García García A, et al. Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging. Cell Stem Cell. 2019;25:407-418.e6 pubmed publisher
Minuesa G, Albanese S, Xie W, Kazansky Y, Worroll D, Chow A, et al. Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia. Nat Commun. 2019;10:2691 pubmed publisher
Pavel Dinu M, Wiebking V, Dejene B, Srifa W, Mantri S, Nicolas C, et al. Gene correction for SCID-X1 in long-term hematopoietic stem cells. Nat Commun. 2019;10:1634 pubmed publisher
Vannini N, Campos V, Girotra M, Trachsel V, Rojas Sutterlin S, Tratwal J, et al. The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance. Cell Stem Cell. 2019;24:405-418.e7 pubmed publisher
Alvarado L, Huntsman H, Cheng H, Townsley D, Winkler T, Feng X, et al. Eltrombopag maintains human hematopoietic stem and progenitor cells under inflammatory conditions mediated by IFNγ. Blood. 2019;: pubmed publisher
Trump L, Nayak R, Singh A, Emberesh S, Wellendorf A, LUTZKO C, et al. Neutrophils Derived from Genetically Modified Human Induced Pluripotent Stem Cells Circulate and Phagocytose Bacteria In Vivo. Stem Cells Transl Med. 2019;8:557-567 pubmed publisher
Juan Colas J, Hitchcock I, Coles M, Johnson S, Krauss T. Quantifying single-cell secretion in real time using resonant hyperspectral imaging. Proc Natl Acad Sci U S A. 2018;115:13204-13209 pubmed publisher
Bari S, Zhong Q, Fan X, Poon Z, Lim A, Lim T, et al. Ex Vivo Expansion of CD34+ CD90+ CD49f+ Hematopoietic Stem and Progenitor Cells from Non-Enriched Umbilical Cord Blood with Azole Compounds. Stem Cells Transl Med. 2018;7:376-393 pubmed publisher
Rio P, Navarro S, Guenechea G, Sánchez Domínguez R, Lamana M, Yañez R, et al. Engraftment and in vivo proliferation advantage of gene-corrected mobilized CD34+ cells from Fanconi anemia patients. Blood. 2017;130:1535-1542 pubmed publisher
Morris E, Fox T, Chakraverty R, Tendeiro R, Snell K, Rivat C, et al. Gene therapy for Wiskott-Aldrich syndrome in a severely affected adult. Blood. 2017;130:1327-1335 pubmed publisher
Higuchi M, Kawamura H, Matsuki H, Hara T, Takahashi M, Saito S, et al. USP10 Is an Essential Deubiquitinase for Hematopoiesis and Inhibits Apoptosis of Long-Term Hematopoietic Stem Cells. Stem Cell Reports. 2016;7:1116-1129 pubmed publisher
Han T, Yang C, Chang K, Zhang D, Imam F, Rana T. Identification of novel genes and networks governing hematopoietic stem cell development. EMBO Rep. 2016;17:1814-1828 pubmed
Nayak R, Trump L, Aronow B, Myers K, Mehta P, Kalfa T, et al. Pathogenesis of ELANE-mutant severe neutropenia revealed by induced pluripotent stem cells. J Clin Invest. 2015;125:3103-16 pubmed publisher
Mende N, Kuchen E, Lesche M, Grinenko T, Kokkaliaris K, Hanenberg H, et al. CCND1-CDK4-mediated cell cycle progression provides a competitive advantage for human hematopoietic stem cells in vivo. J Exp Med. 2015;212:1171-83 pubmed publisher
Sivapatham R, Zeng X. Generation and Characterization of Patient-Specific Induced Pluripotent Stem Cell for Disease Modeling. Methods Mol Biol. 2016;1353:25-44 pubmed publisher
Klco J, Spencer D, Lamprecht T, Sarkaria S, Wylie T, Magrini V, et al. Genomic impact of transient low-dose decitabine treatment on primary AML cells. Blood. 2013;121:1633-43 pubmed publisher
Pelosi E, Castelli G, Martin Padura I, Bordoni V, Santoro S, Conigliaro A, et al. Human haemato-endothelial precursors: cord blood CD34+ cells produce haemogenic endothelium. PLoS ONE. 2012;7:e51109 pubmed publisher
Nakajima Takagi Y, Osawa M, Oshima M, Takagi H, Miyagi S, Endoh M, et al. Role of SOX17 in hematopoietic development from human embryonic stem cells. Blood. 2013;121:447-58 pubmed publisher
Yamagata Y, Parietti V, Stockholm D, Corre G, Poinsignon C, Touleimat N, et al. Lentiviral transduction of CD34(+) cells induces genome-wide epigenetic modifications. PLoS ONE. 2012;7:e48943 pubmed publisher
Burwick N, Coats S, Nakamura T, Shimamura A. Impaired ribosomal subunit association in Shwachman-Diamond syndrome. Blood. 2012;120:5143-52 pubmed publisher
van de Laar L, van den Bosch A, Boonstra A, Binda R, Buitenhuis M, Janssen H, et al. PI3K-PKB hyperactivation augments human plasmacytoid dendritic cell development and function. Blood. 2012;120:4982-91 pubmed publisher
Bauer T, Zagorska A, Jurkin J, Yasmin N, Köffel R, Richter S, et al. Identification of Axl as a downstream effector of TGF-?1 during Langerhans cell differentiation and epidermal homeostasis. J Exp Med. 2012;209:2033-47 pubmed publisher
Roy A, Cowan G, Mead A, Filippi S, Bohn G, Chaidos A, et al. Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21. Proc Natl Acad Sci U S A. 2012;109:17579-84 pubmed publisher
Thiollier C, Lopez C, Gerby B, Ignacimouttou C, Poglio S, Duffourd Y, et al. Characterization of novel genomic alterations and therapeutic approaches using acute megakaryoblastic leukemia xenograft models. J Exp Med. 2012;209:2017-31 pubmed publisher
Dumon S, Walton D, Volpe G, Wilson N, Dassé E, Del Pozzo W, et al. Itga2b regulation at the onset of definitive hematopoiesis and commitment to differentiation. PLoS ONE. 2012;7:e43300 pubmed publisher
Certo M, Gwiazda K, Kuhar R, Sather B, Curinga G, Mandt T, et al. Coupling endonucleases with DNA end-processing enzymes to drive gene disruption. Nat Methods. 2012;9:973-5 pubmed publisher
Gori J, Chandrasekaran D, Kowalski J, Adair J, Beard B, D Souza S, et al. Efficient generation, purification, and expansion of CD34(+) hematopoietic progenitor cells from nonhuman primate-induced pluripotent stem cells. Blood. 2012;120:e35-44 pubmed
Yamaguchi T, Hamanaka S, Kamiya A, Okabe M, Kawarai M, Wakiyama Y, et al. Development of an all-in-one inducible lentiviral vector for gene specific analysis of reprogramming. PLoS ONE. 2012;7:e41007 pubmed publisher
Gao H, Wu X, Sun Y, Zhou S, Silberstein L, Zhu Z. Suppression of homeobox transcription factor VentX promotes expansion of human hematopoietic stem/multipotent progenitor cells. J Biol Chem. 2012;287:29979-87 pubmed publisher
Chu P, Bari S, Fan X, Gay F, Ang J, Chiu G, et al. Intercellular cytosolic transfer correlates with mesenchymal stromal cell rescue of umbilical cord blood cell viability during ex vivo expansion. Cytotherapy. 2012;14:1064-79 pubmed publisher
Aggarwal R, Lu J, Kanji S, Joseph M, Das M, Noble G, et al. Human umbilical cord blood-derived CD34+ cells reverse osteoporosis in NOD/SCID mice by altering osteoblastic and osteoclastic activities. PLoS ONE. 2012;7:e39365 pubmed publisher
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Placke T, Salih H, Kopp H. GITR ligand provided by thrombopoietic cells inhibits NK cell antitumor activity. J Immunol. 2012;189:154-60 pubmed publisher
Nakamura S, Oshima M, Yuan J, Saraya A, Miyagi S, Konuma T, et al. Bmi1 confers resistance to oxidative stress on hematopoietic stem cells. PLoS ONE. 2012;7:e36209 pubmed publisher
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Sangeetha V, Kadekar D, Kale V, Limaye L. Pharmacological inhibition of caspase and calpain proteases: a novel strategy to enhance the homing responses of cord blood HSPCs during expansion. PLoS ONE. 2012;7:e29383 pubmed publisher
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Sarma N, Yaseen N. Amino-terminal enhancer of split (AES) interacts with the oncoprotein NUP98-HOXA9 and enhances its transforming ability. J Biol Chem. 2011;286:38989-9001 pubmed publisher
Okada Y, Nobori H, Shimizu M, Watanabe M, Yonekura M, Nakai T, et al. Multiple ETS family proteins regulate PF4 gene expression by binding to the same ETS binding site. PLoS ONE. 2011;6:e24837 pubmed publisher
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Sun J, Li X, Feng H, Gu H, Blair T, Li J, et al. Magnetic resonance imaging of bone marrow cell-mediated interleukin-10 gene therapy of atherosclerosis. PLoS ONE. 2011;6:e24529 pubmed publisher
Mali R, Ramdas B, Ma P, Shi J, Munugalavadla V, Sims E, et al. Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL. Cancer Cell. 2011;20:357-69 pubmed publisher
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Matthes T, Dunand Sauthier I, Santiago Raber M, Krause K, Donze O, Passweg J, et al. Production of the plasma-cell survival factor a proliferation-inducing ligand (APRIL) peaks in myeloid precursor cells from human bone marrow. Blood. 2011;118:1838-44 pubmed publisher
product information
Product Type :
Protein
Product Name :
Human TPO (Thrombopoietin), Animal-Free Recombinant Protein, PeproTech
Catalog # :
AF-300-18-250UG
Quantity :
250 ug
Price :
US 1902.00
Clonality :
Recombinant
Purity :
purified
Reactivity :
Human
Applications :
ELISA: Assay-dependent, Functional Assay: Assay-dependent, Western Blot: Assay-dependent
Species :
Human
Storage :
-20 C
Description :
Thrombopoietin (TPO, THPO, MPL ligand, megakaryocyte colony-stimulating factor) is responsible for the generation of platelets through its action on hematopoietic cells committed to the megakaryocyte lineage. Binding of thrombopoietin to its receptor, MPL (CD110), initiates a signaling cascade via JAK/STAT, MAPK, and PI3K/AKT signaling pathways that leads to the proliferation and differentiation of megakaryocytes and, ultimately, to the production of platelets (thrombopoiesis). Thrombopoietin is constitutively produced by the liver and has a predicted molecular weight of 38 kDa.
Format :
Lyophilized
Applications w/Dilutions :
ELISA: Assay-dependent, Functional Assay: Assay-dependent, Western Blot: Assay-dependent
Aliases :
C-mpl ligand; Megakaryocyte colony-stimulating factor; megakaryocyte growth and development factor; megakaryocyte stimulating factor; Mgdf; MKCSF; ML; MPL ligand; Mpllg; MSA; Myeloproliferative leukemia virus oncogene ligand; prepro-thrombopoietin; TDH2A; THCYT1; THPO; Thrombopoietin; thyroid microsomal antigen; thyroid peroxidase; thyroperoxidase; Tpo; TPX
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA