Human CCL5 (RANTES), Animal-Free Recombinant Protein, PeproTech | Invitrogen AF-300-06-20UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

protein

product name :

Human CCL5 (RANTES), Animal-Free Recombinant Protein, PeproTech

catalog :

AF-300-06-20UG

quantity :

20 ug

price :

US 260.00

citations: 7

Reference
Yan J, Pandey S, Barnes B, Turner J, Abraham C. T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal Inflammation. Cell Rep. 2020;31:107820 pubmed publisher
Whittall C, Kehoe O, King S, Rot A, Patterson A, Middleton J. A chemokine self-presentation mechanism involving formation of endothelial surface microstructures. J Immunol. 2013;190:1725-36 pubmed publisher
Miller W, Zagorski W, Brenneman J, Avery D, Miller J, O Connor C. US28 is a potent activator of phospholipase C during HCMV infection of clinically relevant target cells. PLoS ONE. 2012;7:e50524 pubmed publisher
Swaminathan G, Rossi F, Sierra L, Gupta A, Navas Martin S, MARTIN GARCIA J. A role for microRNA-155 modulation in the anti-HIV-1 effects of Toll-like receptor 3 stimulation in macrophages. PLoS Pathog. 2012;8:e1002937 pubmed publisher
Wang S, Wu H, Liu S, Wang P, Ou W, Chou W, et al. CCL5 and CCR5 interaction promotes cell motility in human osteosarcoma. PLoS ONE. 2012;7:e35101 pubmed publisher
Jin W, Chen C, Liao H, Gong L, Yuan X, Zhao B, et al. Downregulation of the AU-rich RNA-binding protein ZFP36 in chronic HBV patients: implications for anti-inflammatory therapy. PLoS ONE. 2012;7:e33356 pubmed publisher
Yang D, Postnikov Y, Li Y, Tewary P, de la Rosa G, Wei F, et al. High-mobility group nucleosome-binding protein 1 acts as an alarmin and is critical for lipopolysaccharide-induced immune responses. J Exp Med. 2012;209:157-71 pubmed publisher

product information

Product Type :

Protein

Product Name :

Human CCL5 (RANTES), Animal-Free Recombinant Protein, PeproTech

Catalog # :

AF-300-06-20UG

Quantity :

20 ug

Price :

US 260.00

Clonality :

Recombinant

Purity :

purified

Reactivity :

Human

Applications :

Functional Assay: Assay-dependent

Species :

Human

Storage :

-20 C

Description :

CCL5 (RANTES) is a chemokine gene located on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. CCL5, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells, and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. Diseases associated with CCL5 include Human Immunodeficiency Virus Type 1 and Periapical Granuloma.

Format :

Lyophilized

Applications w/Dilutions :

Functional Assay: Assay-dependent

Aliases :

beta-chemokine RANTES; CC chemokine; C-C motif chemokine 5; C-C motif chemokine ligand 5; CCL5; chemokine (C-C motif) ligand 5; D17S136E; EoCP; eosinophil chemotactic cytokine; MGC17164; MuRantes; OTTHUMP00000197106; RANTES; RANTES protein; RANTES(3-68); RANTES(4-68); regulated upon activation normal T-cell expressed and secreted; regulated upon activation, normally T-expressed, and presumably secreted; Scya5; SIS d; SISd; SIS-delta; SISd; small inducible cytokine A5; small inducible cytokine subfamily A (Cys-Cys), member 5; small-inducible cytokine A5; T cell-specific protein P228; T-cell specific protein p288; T-cell-specific protein RANTES; TCP228; Unknown (protein for MGC:127014)