This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
protein
product name :
Mouse IL-4, Animal-Free Recombinant Protein, PeproTech
catalog :
AF-214-14-50UG
quantity :
50 ug
price :
US 504.00
citations: 122
Reference
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Goswami R, Kaplan M. Gcn5 is required for PU.1-dependent IL-9 induction in Th9 cells. J Immunol. 2012;189:3026-33 pubmed publisher
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Hu P, Nebreda A, Liu Y, Carlesso N, Kaplan M, Kapur R. p38? protein negatively regulates T helper type 2 responses by orchestrating multiple T cell receptor-associated signals. J Biol Chem. 2012;287:33215-26 pubmed
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de Andres B, Prado C, Palacios B, Alía M, Jagtap S, Serrano N, et al. Dynamics of the splenic innate-like CD19?CD45Rlo cell population from adult mice in homeostatic and activated conditions. J Immunol. 2012;189:2300-8 pubmed publisher
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Jin X, Uchiyama M, Zhang Q, Hirai T, Niimi M. Inchingorei-san (TJ-117) and Artemisiae Capillaris Herba Induced Prolonged Survival of Fully Mismatched Cardiac Allografts and Generated Regulatory Cells in Mice. Evid Based Complement Alternat Med. 2012;2012:689810 pubmed publisher
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Qian L, Qian C, Chen Y, Bai Y, Bao Y, Lu L, et al. Regulatory dendritic cells program B cells to differentiate into CD19hiFc?IIbhi regulatory B cells through IFN-? and CD40L. Blood. 2012;120:581-91 pubmed publisher
Pham D, Vincentz J, Firulli A, Kaplan M. Twist1 regulates Ifng expression in Th1 cells by interfering with Runx3 function. J Immunol. 2012;189:832-40 pubmed publisher
Masuoka M, Shiraishi H, Ohta S, Suzuki S, Arima K, Aoki S, et al. Periostin promotes chronic allergic inflammation in response to Th2 cytokines. J Clin Invest. 2012;122:2590-600 pubmed publisher
Gilbert M, Wagner N, Jones S, Wisz A, Roques J, Krum K, et al. Autoreactive preplasma cells break tolerance in the absence of regulation by dendritic cells and macrophages. J Immunol. 2012;189:711-20 pubmed publisher
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Shankar S, Wilson M, DiVietro J, Mentink Kane M, Xie Z, Wynn T, et al. RGS16 attenuates pulmonary Th2/Th17 inflammatory responses. J Immunol. 2012;188:6347-56 pubmed publisher
Thomas R, Gamper C, Ladle B, Powell J, Wells A. De novo DNA methylation is required to restrict T helper lineage plasticity. J Biol Chem. 2012;287:22900-9 pubmed publisher
Verma Gaur J, Hauser J, Grundström T. Negative feedback regulation of antigen receptors through calmodulin inhibition of E2A. J Immunol. 2012;188:6175-83 pubmed publisher
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Abdi K, Singh N, Matzinger P. Lipopolysaccharide-activated dendritic cells: "exhausted" or alert and waiting?. J Immunol. 2012;188:5981-9 pubmed publisher
Eberle M, Dalpke A. Dectin-1 stimulation induces suppressor of cytokine signaling 1, thereby modulating TLR signaling and T cell responses. J Immunol. 2012;188:5644-54 pubmed publisher
Ueda A, Zhou L, Stein P. Fyn promotes Th17 differentiation by regulating the kinetics of ROR?t and Foxp3 expression. J Immunol. 2012;188:5247-56 pubmed publisher
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Uchiyama M, Jin X, Zhang Q, Hirai T, Amano A, Bashuda H, et al. Auditory stimulation of opera music induced prolongation of murine cardiac allograft survival and maintained generation of regulatory CD4+CD25+ cells. J Cardiothorac Surg. 2012;7:26 pubmed publisher
Bassity E, Clark T. Functional identification of dendritic cells in the teleost model, rainbow trout (Oncorhynchus mykiss). PLoS ONE. 2012;7:e33196 pubmed publisher
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Xu X, Yi H, Guo Z, Qian C, Xia S, Yao Y, et al. Splenic stroma-educated regulatory dendritic cells induce apoptosis of activated CD4 T cells via Fas ligand-enhanced IFN-γ and nitric oxide. J Immunol. 2012;188:1168-77 pubmed publisher
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Yang D, Postnikov Y, Li Y, Tewary P, de la Rosa G, Wei F, et al. High-mobility group nucleosome-binding protein 1 acts as an alarmin and is critical for lipopolysaccharide-induced immune responses. J Exp Med. 2012;209:157-71 pubmed publisher
Goswami R, Jabeen R, Yagi R, Pham D, Zhu J, Goenka S, et al. STAT6-dependent regulation of Th9 development. J Immunol. 2012;188:968-75 pubmed publisher
Swartzendruber J, Byrne A, Bryce P. Cutting edge: histamine is required for IL-4-driven eosinophilic allergic responses. J Immunol. 2012;188:536-40 pubmed publisher
Bian Z, Guo Y, Ha B, Zen K, Liu Y. Regulation of the inflammatory response: enhancing neutrophil infiltration under chronic inflammatory conditions. J Immunol. 2012;188:844-53 pubmed publisher
Shen S, Manser T. Direct reduction of antigen receptor expression in polyclonal B cell populations developing in vivo results in light chain receptor editing. J Immunol. 2012;188:47-56 pubmed publisher
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Wang K, Deubel V. Mice with different susceptibility to Japanese encephalitis virus infection show selective neutralizing antibody response and myeloid cell infectivity. PLoS ONE. 2011;6:e24744 pubmed publisher
Cooney L, Towery K, Endres J, Fox D. Sensitivity and resistance to regulation by IL-4 during Th17 maturation. J Immunol. 2011;187:4440-50 pubmed publisher
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product information
Product Type :
Protein
Product Name :
Mouse IL-4, Animal-Free Recombinant Protein, PeproTech
Catalog # :
AF-214-14-50UG
Quantity :
50 ug
Price :
US 504.00
Clonality :
Recombinant
Purity :
purified
Reactivity :
Mouse
Applications :
Functional Assay: Assay-dependent
Species :
Mouse
Storage :
-20 C
Description :
Interleukin-4 (IL-4) is a pleiotropic, immune-modulatory cytokine produced by activated T cells, and serves as a ligand for interleukin 4 receptor. IL-4 has been found to have the broadest range of actions. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play an important role in mediating the immune regulatory signal of IL-4. The IL-4 gene, IL-3, IL-5, IL-13, and CSF2 form a cytokine gene cluster on chromosome 5q. In particular, IL-4 is located in close proximity to IL13 on the chromosome. Further, the IL-4 gene, IL13 and IL5 are found to be coordinated by several long-range regulatory elements over a 120 kilobase range on the chromosome. IL-4 delta 2 is a known splice variant of IL-4.
Format :
Lyophilized
Applications w/Dilutions :
Functional Assay: Assay-dependent
Aliases :
B cell growth factor 1; B_cell stimulatory factor 1; B-cell growth factor 1; B-cell IgG differentiation factor; B-cell stimulatory factor 1; BCGF1; BCGF-1; binetrakin; BSF1; BSF-1; cytokine; H-IL-4; IGG1 induction factor; IL2; IL4; Il-4; Il4e12; ILN; Interleukin; interleukin 4; interleukin 4 variant 2; interleukin 4 variant IL-4delta2; interleukin 4 variant IL-4delta3; interleukin 4 variant IL-4int2A; interleukin 4 variant IL-4int3A; interleukin 4 variant IL-4int3B; Interleukin4; interleukin-4; interleukin-4 precursor; lymphocyte stimulatory factor 1; MGC79402; M-IL-4; Pitrakinra
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA