Human IL-21, Animal-Free Recombinant Protein, PeproTech | Invitrogen AF-200-21-2UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

protein

product name :

Human IL-21, Animal-Free Recombinant Protein, PeproTech

catalog :

AF-200-21-2UG

quantity :

2 ug

price :

US 114.00

citations: 19

Reference
Weng R, Lu H, Lin C, Fan C, Lin R, Huang T, et al. Epigenetic modulation of immune synaptic-cytoskeletal networks potentiates γδ T cell-mediated cytotoxicity in lung cancer. Nat Commun. 2021;12:2163 pubmed publisher
Gonzalez Figueroa P, Roco J, Papa I, Núñez Villacís L, Stanley M, Linterman M, et al. Follicular regulatory T cells produce neuritin to regulate B cells. Cell. 2021;184:1775-1789.e19 pubmed publisher
Schwerd T, Krause F, Twigg S, Aschenbrenner D, Chen Y, Borgmeyer U, et al. A variant in IL6ST with a selective IL-11 signaling defect in human and mouse. Bone Res. 2020;8:24 pubmed publisher
Dowty M, Lin T, Jesson M, Hegen M, Martin D, Katkade V, et al. Janus kinase inhibitors for the treatment of rheumatoid arthritis demonstrate similar profiles of in vitro cytokine receptor inhibition. Pharmacol Res Perspect. 2019;7:e00537 pubmed publisher
Zhang M, Fritsche J, Roszik J, Williams L, Peng X, Chiu Y, et al. RNA editing derived epitopes function as cancer antigens to elicit immune responses. Nat Commun. 2018;9:3919 pubmed publisher
Kumaresan P, Manuri P, Albert N, Maiti S, Singh H, Mi T, et al. Bioengineering T cells to target carbohydrate to treat opportunistic fungal infection. Proc Natl Acad Sci U S A. 2014;111:10660-5 pubmed publisher
Singh H, Figliola M, Dawson M, Olivares S, Zhang L, Yang G, et al. Manufacture of clinical-grade CD19-specific T cells stably expressing chimeric antigen receptor using Sleeping Beauty system and artificial antigen presenting cells. PLoS ONE. 2013;8:e64138 pubmed publisher
Jena B, Maiti S, Huls H, Singh H, Lee D, Champlin R, et al. Chimeric antigen receptor (CAR)-specific monoclonal antibody to detect CD19-specific T cells in clinical trials. PLoS ONE. 2013;8:e57838 pubmed publisher
Schilling B, Harasymczuk M, Schuler P, Egan J, Ferrone S, Whiteside T. IRX-2, a novel immunotherapeutic, enhances functions of human dendritic cells. PLoS ONE. 2013;8:e47234 pubmed publisher
Ding B, Bi E, Chen H, Yu J, Ye B. IL-21 and CD40L synergistically promote plasma cell differentiation through upregulation of Blimp-1 in human B cells. J Immunol. 2013;190:1827-36 pubmed publisher
Cocco M, Stephenson S, Care M, Newton D, Barnes N, Davison A, et al. In vitro generation of long-lived human plasma cells. J Immunol. 2012;189:5773-85 pubmed publisher
Vaeth M, Schliesser U, Müller G, Reissig S, Satoh K, Tuettenberg A, et al. Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3+ regulatory T cells. Proc Natl Acad Sci U S A. 2012;109:16258-63 pubmed publisher
Hodge L, Ziesmer S, Yang Z, Secreto F, Gertz M, Novak A, et al. IL-21 in the bone marrow microenvironment contributes to IgM secretion and proliferation of malignant cells in Waldenstrom macroglobulinemia. Blood. 2012;120:3774-82 pubmed publisher
Ochsenreither S, Majeti R, Schmitt T, Stirewalt D, Keilholz U, Loeb K, et al. Cyclin-A1 represents a new immunogenic targetable antigen expressed in acute myeloid leukemia stem cells with characteristics of a cancer-testis antigen. Blood. 2012;119:5492-501 pubmed publisher
Nagy N, Adori M, Rasul A, Heuts F, Salamon D, Ujvári D, et al. Soluble factors produced by activated CD4+ T cells modulate EBV latency. Proc Natl Acad Sci U S A. 2012;109:1512-7 pubmed publisher
Butler M, Imataki O, Yamashita Y, Tanaka M, Ans xe9 n S, Berezovskaya A, et al. Ex vivo expansion of human CD8+ T cells using autologous CD4+ T cell help. PLoS ONE. 2012;7:e30229 pubmed publisher
Rodríguez Bayona B, Ramos Amaya A, Bernal J, Campos Caro A, Brieva J. Cutting edge: IL-21 derived from human follicular helper T cells acts as a survival factor for secondary lymphoid organ, but not for bone marrow, plasma cells. J Immunol. 2012;188:1578-81 pubmed publisher
Sammicheli S, Dang V, Ruffin N, Pham H, Lantto R, Vivar N, et al. IL-7 promotes CD95-induced apoptosis in B cells via the IFN-?/STAT1 pathway. PLoS ONE. 2011;6:e28629 pubmed publisher
Recher M, Berglund L, Avery D, Cowan M, Gennery A, Smart J, et al. IL-21 is the primary common ? chain-binding cytokine required for human B-cell differentiation in vivo. Blood. 2011;118:6824-35 pubmed publisher

product information

Product Type :

Protein

Product Name :

Human IL-21, Animal-Free Recombinant Protein, PeproTech

Catalog # :

AF-200-21-2UG

Quantity :

2 ug

Price :

US 114.00

Clonality :

Recombinant

Purity :

purified

Reactivity :

Human

Applications :

Functional Assay: Assay-dependent

Species :

Human

Storage :

-20 C

Description :

IL-21 is a 17 kDa immunomodulatory cytokine produced mainly by Natural Killer Cells (NKT), T helper (Th) 17 and T follicular helper (TFH) cells. In TFH cells, IL-21 expression leads to autocrine signaling through the IL-21 receptor (IL-21R) and STAT3, which leads to additional transcriptional activation by Bcl6. As with IFN gamma for Th1 and IL-4 for Th2 cells, IL-21 is critical for TFH cell development and effector function. IL-21 plays a role in T cell-dependent B cell differentiation into plasma cells and memory cells, stimulation of IgG production and induction of apoptotic signaling in naive B cells. In Th17 cells, IL-21 expression and autocrine feedback through STAT3, IRF4 and ROR gamma t lead to upregulation of the IL-23R, thereby preparing Th17 cells for maturation and maintenance by the inflammatory cytokine IL-23. While upregulating IRF4 and ROR gamma t, IL-21 also mediates the downregulation of Foxp3. IL-21 deficient mice are protected from developing colitis upon chemical treatment by their inability to upregulate Th17-associated molecules. In comparison, elevated levels of IL-21 are present in chemically-induced colitis mouse models.

Format :

Lyophilized

Applications w/Dilutions :

Functional Assay: Assay-dependent

Aliases :

CVID11; CX2; il 21; IL21; IL-21; ILN; Interleukin; interleukin 21; Interleukin21; interleukin-21; interleukin-21 isoform; porcine interleukin-21; Za11