Human IL-17A, Animal-Free Recombinant Protein, PeproTech | Invitrogen AF-200-17-25UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

protein

product name :

Human IL-17A, Animal-Free Recombinant Protein, PeproTech

catalog :

AF-200-17-25UG

quantity :

25 ug

price :

US 260.00

citations: 7

Reference
Tsuji G, Hashimoto Hachiya A, Yen V, Takemura M, Yumine A, Furue K, et al. Metformin inhibits IL-1β secretion via impairment of NLRP3 inflammasome in keratinocytes: implications for preventing the development of psoriasis. Cell Death Discov. 2020;6:11 pubmed publisher
Li H, Wu N, Pu C, Hsiao C, Chang D, Hung C. Chrysin alleviates imiquimod-induced psoriasis-like skin inflammation and reduces the release of CCL20 and antimicrobial peptides. Sci Rep. 2020;10:2932 pubmed publisher
Teng Y, Young J, Edwards B, HAYES P, Thompson L, Johnston C, et al. Diverse human VH antibody fragments with bio-therapeutic properties from the Crescendo Mouse. N Biotechnol. 2020;55:65-76 pubmed publisher
Ryzhakov G, Blazek K, Lai C, Udalova I. IL-17 receptor adaptor protein Act1/CIKS plays an evolutionarily conserved role in antiviral signaling. J Immunol. 2012;189:4852-8 pubmed publisher
Zhang S, Yuan J, Yu M, Fan H, Guo Z, Yang R, et al. IL-17A facilitates platelet function through the ERK2 signaling pathway in patients with acute coronary syndrome. PLoS ONE. 2012;7:e40641 pubmed publisher
Liu A, Lee M, McManus B, Choy J. Induction of endothelial nitric oxide synthase expression by IL-17 in human vascular endothelial cells: implications for vascular remodeling in transplant vasculopathy. J Immunol. 2012;188:1544-50 pubmed publisher
Ryzhakov G, Lai C, Blazek K, To K, Hussell T, Udalova I. IL-17 boosts proinflammatory outcome of antiviral response in human cells. J Immunol. 2011;187:5357-62 pubmed publisher

product information

Product Type :

Protein

Product Name :

Human IL-17A, Animal-Free Recombinant Protein, PeproTech

Catalog # :

AF-200-17-25UG

Quantity :

25 ug

Price :

US 260.00

Clonality :

Recombinant

Purity :

purified

Reactivity :

Human

Applications :

Functional Assay: Assay-dependent

Species :

Human

Storage :

-20 C

Description :

Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection. IL-17A is a 32 kDa long, disulfide-linked homodimer consisting of 136 amino acids that is a member of a six-species family of proteins (IL-17A-17F) and signals through the IL-17 receptor (IL-17R/CDw217). High levels of IL-17A homodimer are produced by activated peripheral blood CD4+ T-cells, and IL-17A also enhances expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts. In particular, human IL-17A also stimulates epithelial, endothelial, or fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2. In the presence of human IL-17A, fibroblasts can sustain the proliferation of CD34+ hematopoietic progenitors and induce maturation into neutrophils. Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse receptor. IL-17A regulates the activities of NF-kappa B and mitogen-activated protein kinases, stimulates the expression of IL-6 and cyclooxygenase-2 (PTGS2/COX-2), and enhances the production of nitric oxide (NO).

Format :

Lyophilized

Applications w/Dilutions :

Functional Assay: Assay-dependent

Aliases :

Ctla8; CTLA-8; cytokine; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; il 17; Il17; IL-17; IL17A; IL-17a; ILN; Interleukin; interleukin 17; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin 17 precursor; interleukin 17A; interleukin-17; Interleukin17A; interleukin-17A; R-IL-17-A