Human IL-10, Animal-Free Recombinant Protein, PeproTech | Invitrogen AF-200-10-1MG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

protein

product name :

Human IL-10, Animal-Free Recombinant Protein, PeproTech

catalog :

AF-200-10-1MG

quantity :

1 mg

price :

US 6600.00

citations: 7

Reference
Mena J, Alloza I, Tulloch Navarro R, Aldekoa A, D xed ez Garc xed a J, Villanueva Etxebarria A, et al. Genomic Multiple Sclerosis Risk Variants Modulate the Expression of the ANKRD55-IL6ST Gene Region in Immature Dendritic Cells. Front Immunol. 2021;12:816930 pubmed publisher
Yamashiro C, Tokuda K, Kobayashi Y, Higashijima F, Yoshimoto T, Ota M, et al. Benzalkonium chloride-induced myofibroblastic transdifferentiation of Tenon's capsule fibroblasts is inhibited by coculture with corneal epithelial cells or by interleukin-10. Sci Rep. 2021;11:16096 pubmed publisher
Scott Taylor T, Whiting K, Pettengell R, Webster D. Enhanced formation of giant cells in common variable immunodeficiency: Relation to granulomatous disease. Clin Immunol. 2017;175:1-9 pubmed publisher
Zhao M, Zhang R, Xu X, Liu Y, Zhang H, Zhai X, et al. IL-10 reduces levels of apoptosis in Toxoplasma gondii-infected trophoblasts. PLoS ONE. 2013;8:e56455 pubmed publisher
Malavige G, Huang L, Salimi M, Gomes L, Jayaratne S, Ogg G. Cellular and cytokine correlates of severe dengue infection. PLoS ONE. 2012;7:e50387 pubmed publisher
Braun D, Fribourg M, Sealfon S. Cytokine response is determined by duration of receptor and signal transducers and activators of transcription 3 (STAT3) activation. J Biol Chem. 2013;288:2986-93 pubmed publisher
Shi B, Ren G, Hu Y, Wang S, Zhang Z, Yuan Z. HBsAg inhibits IFN-? production in plasmacytoid dendritic cells through TNF-? and IL-10 induction in monocytes. PLoS ONE. 2012;7:e44900 pubmed

product information

Product Type :

Protein

Product Name :

Human IL-10, Animal-Free Recombinant Protein, PeproTech

Catalog # :

AF-200-10-1MG

Quantity :

1 mg

Price :

US 6600.00

Clonality :

Recombinant

Purity :

purified

Reactivity :

Human

Applications :

Functional Assay: Assay-dependent

Species :

Human

Storage :

-20 C

Description :

IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes. This cytokine has various effects on immunoregulation and inflammation, including down-regulating the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. Additionally, IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice have suggested that this cytokine is an essential immunoregulator in the intestinal tract. Mutations in this gene have been associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.

Format :

Lyophilized

Applications w/Dilutions :

Functional Assay: Assay-dependent

Aliases :

CSIF; cytokine; Cytokine synthesis inhibitory factor; GVHDS; H-IL-10; il 10; IL10; IL-10; IL-10 precursor; IL10A; IL10X; ILN; Interleukin; interleukin 10; Interleukin10; interleukin-10; MGC126450; MGC126451; RP11-262N9.1; T-cell growth inhibitory factor; TGIF